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Article: Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations.

TitleIdentifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations.
Authors
Issue Date2014
Citation
Schizophrenia Bulletin, 2014 How to Cite?
AbstractRecent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi–center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
Persistent Identifierhttp://hdl.handle.net/10722/200823
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorEU-GEI, 1en_US
dc.contributor.authorCampbell, DDen_US
dc.contributor.authorEU_GEI, 2en_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorButler, WLen_US
dc.contributor.authorEU_GEI, 3en_US
dc.contributor.authorvan Os, Jen_US
dc.contributor.authorCherny, SSen_US
dc.contributor.authorChen, EYHen_US
dc.contributor.authorLi, Men_US
dc.date.accessioned2014-08-21T07:02:40Z-
dc.date.available2014-08-21T07:02:40Z-
dc.date.issued2014en_US
dc.identifier.citationSchizophrenia Bulletin, 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/200823-
dc.description.abstractRecent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi–center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.en_US
dc.languageengen_US
dc.relation.ispartofSchizophrenia Bulletinen_US
dc.titleIdentifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations.en_US
dc.typeArticleen_US
dc.identifier.emailCampbell, DD: ddc123@hku.hken_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.emailButler, WL: wbutler@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.identifier.doi10.1093/schbul/sbu069en_US
dc.identifier.pmid24860087-
dc.identifier.scopuseid_2-s2.0-84902577447-
dc.identifier.hkuros232194en_US
dc.identifier.isiWOS:000338130300004-

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