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- Publisher Website: 10.1111/bcp.12474
- Scopus: eid_2-s2.0-84942552796
- PMID: 25060360
- WOS: WOS:000362084200033
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Article: Adverse drug reactions – examples of detection of rare events using databases
Title | Adverse drug reactions – examples of detection of rare events using databases |
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Authors | |
Keywords | Adverse drug reactions Attention deficit hyperactivity disorder Database Retinal detachment Sudden death Toxic epidermal necrolysis (TEN) |
Issue Date | 2015 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2125 |
Citation | British Journal of Clinical Pharmacology, 2015, v. 80 n. 4, p. 855-861 How to Cite? |
Abstract | It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population‐based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient characterisation and assessment of the associated factors. While direct causality cannot be established and confounders cannot be ignored, databases present an opportunity to explore and quantify rare events. The use of databases for the detection of rare adverse events in the following conditions, sudden death associated with attention deficit hyperactivity disorder (ADHD) treatment, retinal detachment associated with the use of fluoroquinolones and toxic epidermal necrolysis associated with drug exposure, are discussed as examples. In general, rare adverse events tend to have immediate and important clinical implications and may be life‐threatening. An understanding of the causative factors is therefore important, in addition to the research methodologies and database platforms that enable the undertaking of the research. |
Persistent Identifier | http://hdl.handle.net/10722/200778 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.046 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, EW | - |
dc.contributor.author | Liu, Q | - |
dc.contributor.author | Chui, SLC | - |
dc.contributor.author | Sing, CW | - |
dc.contributor.author | Wong, LYL | - |
dc.contributor.author | Wong, ICK | - |
dc.date.accessioned | 2014-08-21T07:01:02Z | - |
dc.date.available | 2014-08-21T07:01:02Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | British Journal of Clinical Pharmacology, 2015, v. 80 n. 4, p. 855-861 | - |
dc.identifier.issn | 0306-5251 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200778 | - |
dc.description.abstract | It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population‐based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient characterisation and assessment of the associated factors. While direct causality cannot be established and confounders cannot be ignored, databases present an opportunity to explore and quantify rare events. The use of databases for the detection of rare adverse events in the following conditions, sudden death associated with attention deficit hyperactivity disorder (ADHD) treatment, retinal detachment associated with the use of fluoroquinolones and toxic epidermal necrolysis associated with drug exposure, are discussed as examples. In general, rare adverse events tend to have immediate and important clinical implications and may be life‐threatening. An understanding of the causative factors is therefore important, in addition to the research methodologies and database platforms that enable the undertaking of the research. | - |
dc.language | eng | - |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2125 | - |
dc.relation.ispartof | British Journal of Clinical Pharmacology | - |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.subject | Adverse drug reactions | - |
dc.subject | Attention deficit hyperactivity disorder | - |
dc.subject | Database | - |
dc.subject | Retinal detachment | - |
dc.subject | Sudden death | - |
dc.subject | Toxic epidermal necrolysis (TEN) | - |
dc.title | Adverse drug reactions – examples of detection of rare events using databases | - |
dc.type | Article | - |
dc.identifier.email | Chan, EW: ewchan@hku.hk | - |
dc.identifier.email | Chui, SLC: cslchui@hku.hk | - |
dc.identifier.email | Wong, ICK: wongick@hku.hk | - |
dc.identifier.authority | Chan, EW=rp01587 | - |
dc.identifier.authority | Chui, SLC=rp02527 | - |
dc.identifier.authority | Wong, ICK=rp01480 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/bcp.12474 | - |
dc.identifier.pmid | 25060360 | - |
dc.identifier.pmcid | PMC4594728 | - |
dc.identifier.scopus | eid_2-s2.0-84942552796 | - |
dc.identifier.hkuros | 233004 | - |
dc.identifier.volume | 80 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 855 | - |
dc.identifier.epage | 861 | - |
dc.identifier.isi | WOS:000362084200033 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0306-5251 | - |