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Article: Metaplastic breast cancer – a rare but challenging entity.

TitleMetaplastic breast cancer – a rare but challenging entity.
Authors
Issue Date2013
PublisherResearch Trends (P) Ltd. The Journal's web site is located at http://www.researchtrends.net/tia/title.asp?id=57
Citation
Trends in Cancer Research, 2013, v. 9, p. 65-71 How to Cite?
AbstractMetaplastic breast carcinoma is a rare type of breast cancer. Due largely to the lack of drug targets and the high heterogeneity of tumor components, metaplastic breast cancers are difficult to manage. The incidence of metaplastic breast cancer has been rising during the past decade, becoming the leading cause of cancer-related death among women in the Western world. However, there is no standard treatment for this subgroup of breast cancer. Individualized genetic profiling may provide promising targets for therapeutic development. The transcriptional regulator p63, a member of the p53 tumor suppressor family, appears to play a key role in the maintenance and regeneration of epithelial stem cells and is actively involved in the pathogenesis of metaplastic breast carcinoma. Positivity of p63 has been applied in the diagnosis of metaplastic carcinomas of the breast. Further explorations are necessary to reveal the mechanisms underlying p63 upregulation in metaplastic breast carcinomas and the downstream gene targets of this protein, which will facilitate the therapeutic development for this disease.
Persistent Identifierhttp://hdl.handle.net/10722/200777
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChen, Jen_US
dc.contributor.authorWang, Yen_US
dc.date.accessioned2014-08-21T07:01:02Z-
dc.date.available2014-08-21T07:01:02Z-
dc.date.issued2013en_US
dc.identifier.citationTrends in Cancer Research, 2013, v. 9, p. 65-71en_US
dc.identifier.issn0973-1040en_US
dc.identifier.urihttp://hdl.handle.net/10722/200777-
dc.description.abstractMetaplastic breast carcinoma is a rare type of breast cancer. Due largely to the lack of drug targets and the high heterogeneity of tumor components, metaplastic breast cancers are difficult to manage. The incidence of metaplastic breast cancer has been rising during the past decade, becoming the leading cause of cancer-related death among women in the Western world. However, there is no standard treatment for this subgroup of breast cancer. Individualized genetic profiling may provide promising targets for therapeutic development. The transcriptional regulator p63, a member of the p53 tumor suppressor family, appears to play a key role in the maintenance and regeneration of epithelial stem cells and is actively involved in the pathogenesis of metaplastic breast carcinoma. Positivity of p63 has been applied in the diagnosis of metaplastic carcinomas of the breast. Further explorations are necessary to reveal the mechanisms underlying p63 upregulation in metaplastic breast carcinomas and the downstream gene targets of this protein, which will facilitate the therapeutic development for this disease.en_US
dc.languageengen_US
dc.publisherResearch Trends (P) Ltd. The Journal's web site is located at http://www.researchtrends.net/tia/title.asp?id=57en_US
dc.relation.ispartofTrends in Cancer Researchen_US
dc.titleMetaplastic breast cancer – a rare but challenging entity.en_US
dc.typeArticleen_US
dc.identifier.emailWang, Y: yuwanghk@hku.hken_US
dc.identifier.authorityWang, Y=rp00239en_US
dc.identifier.hkuros232285en_US
dc.identifier.volume9en_US
dc.identifier.spage65en_US
dc.identifier.epage71en_US
dc.publisher.placeIndiaen_US

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