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Article: Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?

TitleEmergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?
Authors
Issue Date2014
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal of Infection, 2014, v. 68 n. 3, p. 205-215 How to Cite?
AbstractIn December 2013, China reported the first human case of avian influenza A(H10N8). A 73-year-old female with chronic diseases who had visited a live poultry market succumbed with community-acquired pneumonia. While human infections with avian influenza viruses are usually associated with subtypes prevalent in poultries, A(H10N8) isolates were mostly found in migratory birds and only recently in poultries. Although not possible to predict whether this single intrusion by A(H10N8) is an accident or the start of another epidemic like the preceding A(H7N9) and A(H5N1), several features suggest that A(H10N8) is a potential threat to humans. Recombinant H10 could attach to human respiratory epithelium, and A(H10N4) virus could cause severe infections in minks and chickens. A(H10N8) viruses contain genetic markers for mammalian adaptation and virulence in the haemagglutinin (A135T, S138A[H3 numbering]), M1(N30D, T215A), NS1(P42S) and PB2(E627K) protein. Studies on this human A(H10N8) isolate will reveal its adaptability to humans. Clinicians should alert the laboratory to test for A(H5,6,7,9,10) viruses in patients with epidemiological exposure in endemic geographical areas especially when human influenza A(H1,3) and B are negative. Vigilant virological and serological surveillance for A(H10N8) in human, poultry and wild bird is important for following the trajectory of this emerging influenza virus.
Persistent Identifierhttp://hdl.handle.net/10722/200735
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTo, KKW-
dc.contributor.authorTsang, AKL-
dc.contributor.authorChan, JFW-
dc.contributor.authorCheng, VCC-
dc.contributor.authorChen, H-
dc.contributor.authorYuen, KY-
dc.date.accessioned2014-08-21T06:58:06Z-
dc.date.available2014-08-21T06:58:06Z-
dc.date.issued2014-
dc.identifier.citationJournal of Infection, 2014, v. 68 n. 3, p. 205-215-
dc.identifier.issn0163-4453-
dc.identifier.urihttp://hdl.handle.net/10722/200735-
dc.description.abstractIn December 2013, China reported the first human case of avian influenza A(H10N8). A 73-year-old female with chronic diseases who had visited a live poultry market succumbed with community-acquired pneumonia. While human infections with avian influenza viruses are usually associated with subtypes prevalent in poultries, A(H10N8) isolates were mostly found in migratory birds and only recently in poultries. Although not possible to predict whether this single intrusion by A(H10N8) is an accident or the start of another epidemic like the preceding A(H7N9) and A(H5N1), several features suggest that A(H10N8) is a potential threat to humans. Recombinant H10 could attach to human respiratory epithelium, and A(H10N4) virus could cause severe infections in minks and chickens. A(H10N8) viruses contain genetic markers for mammalian adaptation and virulence in the haemagglutinin (A135T, S138A[H3 numbering]), M1(N30D, T215A), NS1(P42S) and PB2(E627K) protein. Studies on this human A(H10N8) isolate will reveal its adaptability to humans. Clinicians should alert the laboratory to test for A(H5,6,7,9,10) viruses in patients with epidemiological exposure in endemic geographical areas especially when human influenza A(H1,3) and B are negative. Vigilant virological and serological surveillance for A(H10N8) in human, poultry and wild bird is important for following the trajectory of this emerging influenza virus.-
dc.languageeng-
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf-
dc.relation.ispartofJournal of Infection-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subject.meshInfluenza A virus - classification - isolation and purification-
dc.subject.meshInfluenza in Birds - epidemiology - virology-
dc.subject.meshInfluenza, Human - epidemiology - prevention and control - transmission - virology-
dc.subject.meshPhylogeny-
dc.subject.meshPoultry-
dc.titleEmergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?-
dc.typeArticle-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityChen, H=rp00383-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.doi10.1016/j.jinf.2013.12.014-
dc.identifier.pmid24406432-
dc.identifier.scopuseid_2-s2.0-84894075244-
dc.identifier.hkuros234917-
dc.identifier.volume68-
dc.identifier.issue3-
dc.identifier.spage205-
dc.identifier.epage215-
dc.identifier.isiWOS:000331712100001-
dc.publisher.placeUnited Kingdom-

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