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Article: High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients

TitleHigh burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients
Authors
Issue Date2014
PublisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org
Citation
Journal of Medical Microbiology, 2014, v. 63 n. pt. 6, p. 878-883 How to Cite?
AbstractFew studies have described how an expanding elderly population influences the burden of antimicrobial resistance in micro-organisms. This study aimed to investigate trends in agestratified extended-spectrum β-lactamase (ESBL)-positive Escherichia coli metrics in relation to an ageing population. The antimicrobial resistance database of E. coli from a healthcare region in Hong Kong from 2003 to 2012 was retrospectively reviewed. Future trends in age-stratified ESBL metrics were predicted up to 2022. Susceptibility results of clinical E. coli isolates from patients aged 0-74 years (n517 853) and aged ≥75 years (n517 047) were analysed. For the period 2003-2012, 23.7% of the hospital admissions were of patients aged ≥75 years. However, approximately half of the annual ESBL-positive E. coli isolates were recovered from patients aged ≥75 years, being 55.0% (233/424) in 2003 and 56.0% (639/1142) in 2012. During this period of time, the annual prevalence and cumulative incidence of ESBL-positive E. coli in patients aged ≥75 years were significantly higher than in patients aged 0-74 years. From 2012-2022, it is predicted that ESBL-positive E. coli prevalence among patients aged 0-74 years and ≥75 years would increase from 25.4% to 50.2% and from 30.8% to 70.0 %, respectively. In 2022, the predicted ESBL-positive E. coli cumulative incidence would be 63.7 per 10 000 admissions and 178.7 per 10 000 admissions among patients aged 0-74 years and≥75 years, respectively. In conclusion, a rapidly expanding elderly population would substantially add to the burden of ESBL. © 2014 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/200727
ISSN
2015 Impact Factor: 2.269
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PL-
dc.contributor.authorChau, PH-
dc.contributor.authorYan, MK-
dc.contributor.authorChow, KH-
dc.contributor.authorChen, JHK-
dc.contributor.authorWong, SCY-
dc.contributor.authorCheng, VCC-
dc.date.accessioned2014-08-21T06:58:00Z-
dc.date.available2014-08-21T06:58:00Z-
dc.date.issued2014-
dc.identifier.citationJournal of Medical Microbiology, 2014, v. 63 n. pt. 6, p. 878-883-
dc.identifier.issn0022-2615-
dc.identifier.urihttp://hdl.handle.net/10722/200727-
dc.description.abstractFew studies have described how an expanding elderly population influences the burden of antimicrobial resistance in micro-organisms. This study aimed to investigate trends in agestratified extended-spectrum β-lactamase (ESBL)-positive Escherichia coli metrics in relation to an ageing population. The antimicrobial resistance database of E. coli from a healthcare region in Hong Kong from 2003 to 2012 was retrospectively reviewed. Future trends in age-stratified ESBL metrics were predicted up to 2022. Susceptibility results of clinical E. coli isolates from patients aged 0-74 years (n517 853) and aged ≥75 years (n517 047) were analysed. For the period 2003-2012, 23.7% of the hospital admissions were of patients aged ≥75 years. However, approximately half of the annual ESBL-positive E. coli isolates were recovered from patients aged ≥75 years, being 55.0% (233/424) in 2003 and 56.0% (639/1142) in 2012. During this period of time, the annual prevalence and cumulative incidence of ESBL-positive E. coli in patients aged ≥75 years were significantly higher than in patients aged 0-74 years. From 2012-2022, it is predicted that ESBL-positive E. coli prevalence among patients aged 0-74 years and ≥75 years would increase from 25.4% to 50.2% and from 30.8% to 70.0 %, respectively. In 2022, the predicted ESBL-positive E. coli cumulative incidence would be 63.7 per 10 000 admissions and 178.7 per 10 000 admissions among patients aged 0-74 years and≥75 years, respectively. In conclusion, a rapidly expanding elderly population would substantially add to the burden of ESBL. © 2014 The Authors.-
dc.languageeng-
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org-
dc.relation.ispartofJournal of Medical Microbiology-
dc.rightsJournal of Medical Microbiology. Copyright © Society for General Microbiology.-
dc.rightsThis is an author manuscript that has been accepted for publication in [Journal Title], copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in [Journal Title]. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at [Journal URL], and is freely available without a subscription.-
dc.titleHigh burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients-
dc.typeArticle-
dc.identifier.emailHo, PL: plho@hkucc.hku.hk-
dc.identifier.emailChau, PH: phpchau@hku.hk-
dc.identifier.emailChow, KH: khchowb@hku.hk-
dc.identifier.emailChen, JHK: jonchk@hku.hk-
dc.identifier.emailWong, SCY: wcy288@hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.authorityHo, PL=rp00406-
dc.identifier.authorityChau, PH=rp00574-
dc.identifier.authorityChow, KH=rp00370-
dc.identifier.doi10.1099/jmm.0.068270-0-
dc.identifier.pmid24722797-
dc.identifier.scopuseid_2-s2.0-84901326838-
dc.identifier.hkuros232531-
dc.identifier.volume63-
dc.identifier.issuept. 6-
dc.identifier.spage878-
dc.identifier.epage883-
dc.identifier.isiWOS:000338815500016-
dc.publisher.placeUnited Kingdom-

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