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Article: Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair

TitleSilver nanoparticles alter proteoglycan expression in the promotion of tendon repair
Authors
Issue Date2014
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
Citation
Nanomedicine: Nanotechnology, Biology and Medicine, 2014, v. 10 n. 7, p. 1375-1383 How to Cite?
AbstractThis study demonstrates a novel method of using silver nanoparticles for Achilles tendon injury healing. In vitro results indicated a stimulatory effect on cell proliferation and collagen synthesis with silver nanoparticles. Biomechanical test on the 42-day post operation Achilles tendon sample exhibited a significant improvement in tensile modulus when compared to the untreated group. Histology suggested that silver nanoparticles promoted cell alignment and proteoglycan synthesis. The collagen deposition was also improved. An alleviation of tumor necrosis factor α, and an increase in fibromodulin and proliferating cell nuclear antigen expression were seen in silver nanoparticles group by immunohistochemistry. This study further corroborates the finding of our previous study that silver nanoparticles help to restore the functionality of injured connective tissues. We believe that the anti-inflammatory nature of silver nanoparticles has an important role in accelerating the healing process and reducing scarring, leading to better functional outcome. From the clinical editor: Tendon healing after surgeries remains a slow and tedious process, typically requiring several weeks of recovery time and gradual introduction of physical therapy. There are no currently utilized methods that could promote tendon healing. In this study, silver nanoparticles are reported to facilitate Achilles tendon repair in a model system, through increased proteoglycan and collagen synthesis, paving the way to potential clinical applications in the future. Copyright © 2014 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/200653
ISSN
2015 Impact Factor: 5.671
2015 SCImago Journal Rankings: 1.886

 

DC FieldValueLanguage
dc.contributor.authorKwan, KHL-
dc.contributor.authorYeung, KWK-
dc.contributor.authorLiu, X-
dc.contributor.authorWong, KKY-
dc.contributor.authorShum, HC-
dc.contributor.authorLam, YW-
dc.contributor.authorCheng, SH-
dc.contributor.authorCheung, KMC-
dc.contributor.authorTo, MKT-
dc.date.accessioned2014-08-21T06:54:14Z-
dc.date.available2014-08-21T06:54:14Z-
dc.date.issued2014-
dc.identifier.citationNanomedicine: Nanotechnology, Biology and Medicine, 2014, v. 10 n. 7, p. 1375-1383-
dc.identifier.issn1549-9634-
dc.identifier.urihttp://hdl.handle.net/10722/200653-
dc.description.abstractThis study demonstrates a novel method of using silver nanoparticles for Achilles tendon injury healing. In vitro results indicated a stimulatory effect on cell proliferation and collagen synthesis with silver nanoparticles. Biomechanical test on the 42-day post operation Achilles tendon sample exhibited a significant improvement in tensile modulus when compared to the untreated group. Histology suggested that silver nanoparticles promoted cell alignment and proteoglycan synthesis. The collagen deposition was also improved. An alleviation of tumor necrosis factor α, and an increase in fibromodulin and proliferating cell nuclear antigen expression were seen in silver nanoparticles group by immunohistochemistry. This study further corroborates the finding of our previous study that silver nanoparticles help to restore the functionality of injured connective tissues. We believe that the anti-inflammatory nature of silver nanoparticles has an important role in accelerating the healing process and reducing scarring, leading to better functional outcome. From the clinical editor: Tendon healing after surgeries remains a slow and tedious process, typically requiring several weeks of recovery time and gradual introduction of physical therapy. There are no currently utilized methods that could promote tendon healing. In this study, silver nanoparticles are reported to facilitate Achilles tendon repair in a model system, through increased proteoglycan and collagen synthesis, paving the way to potential clinical applications in the future. Copyright © 2014 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed-
dc.relation.ispartofNanomedicine: Nanotechnology, Biology and Medicine-
dc.titleSilver nanoparticles alter proteoglycan expression in the promotion of tendon repair-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.emailWong, KKY: kkywong@hku.hk-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.emailTo, MKT: mikektto@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309en_US
dc.identifier.authorityWong, KKY=rp01392en_US
dc.identifier.authorityShum, HC=rp01439en_US
dc.identifier.authorityCheung, KMC=rp00387en_US
dc.identifier.authorityTo, MKT=rp00302en_US
dc.identifier.doi10.1016/j.nano.2013.11.015-
dc.identifier.pmid24333594-
dc.identifier.hkuros233070-
dc.identifier.hkuros242030-
dc.identifier.volume10-
dc.identifier.issue7-
dc.identifier.spage1375-
dc.identifier.epage1383-
dc.publisher.placeUnited States-

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