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Article: Radioprotective effect of lidocaine on function and ultrastructure of salivary glands receiving fractionated radiation

TitleRadioprotective effect of lidocaine on function and ultrastructure of salivary glands receiving fractionated radiation
Authors
KeywordsRadioprotection
Salivary glands
Sialoscintigraphy
Xerostomia
Lidocaine
Issue Date2012
Citation
International Journal of Radiation Oncology - Biology - Physics, 2012, v. 82, n. 4, p. e623-e630 How to Cite?
AbstractPurpose: Radiation-induced xerostomia still represents a common side effect after radiotherapy for head-and-neck malignancies. The aim of the present study was to examine the radioprotective effect of lidocaine hydrochloride during fractionated radiation in an experimental animal model. Methods and Materials: To evaluate the influence of different radiation doses on salivary gland function and the radioprotective effect of lidocaine, rabbits were irradiated with 15, 25, 30, and 35 Gy (equivalent doses in 2-Gy fractions equivalent to 24, 40, 48, and 56 Gy, respectively). Lidocaine hydrochloride (10 and 12 mg/kg) was administered before every radiation fraction in the treatment groups. Salivary gland function was assessed by flow sialometry and sialoscintigraphy, and the morphologic changes were evaluated using transmission electron microscopy. Results: Functional impairment was first observed after 35 Gy and pretreatment with lidocaine improved radiation tolerance of both parotid and submandibular glands. The use of 12 mg/kg lidocaine was superior and displayed significant radioprotection with regard to flow sialometry and sialoscintigraphy. The ultrastructure was largely preserved after pretreatment with both lidocaine doses. Conclusions: Lidocaine represents an effective radioprotective agent and a promising approach for clinical application to avoid radiation-induced functional impairment of salivary glands. Copyright © 2012 Elsevier Inc. Printed in the USA. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/200094
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHakim, Samer George-
dc.contributor.authorBenedek, Geza Attila-
dc.contributor.authorSu, Yuxiong-
dc.contributor.authorJacobsen, Hans Christian-
dc.contributor.authorKlinger, Matthias Heinrich Friedrich-
dc.contributor.authorDendorfer, Andreas-
dc.contributor.authorHemmelmann, Claudia-
dc.contributor.authorMeller, Birgit-
dc.contributor.authorNadrowitz, Roger-
dc.contributor.authorRades, Dirk-
dc.contributor.authorSieg, Peter-
dc.date.accessioned2014-07-26T23:11:08Z-
dc.date.available2014-07-26T23:11:08Z-
dc.date.issued2012-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2012, v. 82, n. 4, p. e623-e630-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/200094-
dc.description.abstractPurpose: Radiation-induced xerostomia still represents a common side effect after radiotherapy for head-and-neck malignancies. The aim of the present study was to examine the radioprotective effect of lidocaine hydrochloride during fractionated radiation in an experimental animal model. Methods and Materials: To evaluate the influence of different radiation doses on salivary gland function and the radioprotective effect of lidocaine, rabbits were irradiated with 15, 25, 30, and 35 Gy (equivalent doses in 2-Gy fractions equivalent to 24, 40, 48, and 56 Gy, respectively). Lidocaine hydrochloride (10 and 12 mg/kg) was administered before every radiation fraction in the treatment groups. Salivary gland function was assessed by flow sialometry and sialoscintigraphy, and the morphologic changes were evaluated using transmission electron microscopy. Results: Functional impairment was first observed after 35 Gy and pretreatment with lidocaine improved radiation tolerance of both parotid and submandibular glands. The use of 12 mg/kg lidocaine was superior and displayed significant radioprotection with regard to flow sialometry and sialoscintigraphy. The ultrastructure was largely preserved after pretreatment with both lidocaine doses. Conclusions: Lidocaine represents an effective radioprotective agent and a promising approach for clinical application to avoid radiation-induced functional impairment of salivary glands. Copyright © 2012 Elsevier Inc. Printed in the USA. All rights reserved.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.subjectRadioprotection-
dc.subjectSalivary glands-
dc.subjectSialoscintigraphy-
dc.subjectXerostomia-
dc.subjectLidocaine-
dc.titleRadioprotective effect of lidocaine on function and ultrastructure of salivary glands receiving fractionated radiation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2011.09.017-
dc.identifier.pmid22245203-
dc.identifier.scopuseid_2-s2.0-84857924114-
dc.identifier.volume82-
dc.identifier.issue4-
dc.identifier.spagee623-
dc.identifier.epagee630-
dc.identifier.eissn1879-355X-
dc.identifier.isiWOS:000300980300007-

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