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Article: Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses

TitleMice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses
Authors
Issue Date1998
Citation
Journal of General Virology, 1998, v. 79, n. 4, p. 825-830 How to Cite?
AbstractMice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were significantly more susceptible to herpes simplex virus (HSV)-1 infection, displayed a delayed clearance of virus from the dorsal root ganglia (DRG) and exhibited an increase in the frequency of virus reactivation in DRG compared with similarly infected heterozygous mice. The infected iNOS-deficient mice developed enhanced Th1-type immune responses and their spleen cells produced higher concentrations of IL-12 than similarly infected heterozygous mice. This finding suggests that iNOS plays an important role in resistance against HSV-1 infection. Furthermore, nitric oxide (NO) may block the development of Th1 cells via inhibition of IL-12 synthesis and thereby play a role in immune regulation.
Persistent Identifierhttp://hdl.handle.net/10722/200065
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMacLean, Alasdair R.-
dc.contributor.authorWei, Xiaoqing-
dc.contributor.authorHuang, Fangping-
dc.contributor.authorAl-Alem, Umaima A H-
dc.contributor.authorChan, WoonLing-
dc.contributor.authorLiew, Fooyew-
dc.date.accessioned2014-07-26T23:11:05Z-
dc.date.available2014-07-26T23:11:05Z-
dc.date.issued1998-
dc.identifier.citationJournal of General Virology, 1998, v. 79, n. 4, p. 825-830-
dc.identifier.issn0022-1317-
dc.identifier.urihttp://hdl.handle.net/10722/200065-
dc.description.abstractMice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were significantly more susceptible to herpes simplex virus (HSV)-1 infection, displayed a delayed clearance of virus from the dorsal root ganglia (DRG) and exhibited an increase in the frequency of virus reactivation in DRG compared with similarly infected heterozygous mice. The infected iNOS-deficient mice developed enhanced Th1-type immune responses and their spleen cells produced higher concentrations of IL-12 than similarly infected heterozygous mice. This finding suggests that iNOS plays an important role in resistance against HSV-1 infection. Furthermore, nitric oxide (NO) may block the development of Th1 cells via inhibition of IL-12 synthesis and thereby play a role in immune regulation.-
dc.languageeng-
dc.relation.ispartofJournal of General Virology-
dc.titleMice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9568978-
dc.identifier.scopuseid_2-s2.0-0031925465-
dc.identifier.volume79-
dc.identifier.issue4-
dc.identifier.spage825-
dc.identifier.epage830-
dc.identifier.isiWOS:000072889400022-

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