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Article: Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats

TitleDifferential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats
Authors
KeywordsChlorhexidine digluconate
Periodontitis/therapy
Porphyromonas gingivalis
Actinobacillus actinomycetemcomitans
Amoxicillin
Antibiotics
Metronidazole
Issue Date1998
Citation
Journal of Clinical Periodontology, 1998, v. 25, n. 1, p. 1-10 How to Cite?
Abstract48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). Subgingival plaque and swab samples from tongue, tonsils, and buccal mucosa were taken at baseline, 10 days and 3, 6, 9, and 12 months. A. actinomycetemcomitans was detected in the oral cavity, i.e., subgingival plaque and/or mucous membranes, less frequently in test patients compared to controls at 9 and 12 months (p<0.01), whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy (p<0.001). At any time after therapy, A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1 of 13 (8%) control patients harboring this pathogen at baseline; P. gingivalis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months, P. gingivalis persisted or reoccurred. © Munksgaard, 1998.
Persistent Identifierhttp://hdl.handle.net/10722/200062
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFlemmig, Thomas Frank-
dc.contributor.authorMilián, E.-
dc.contributor.authorKopp, Corinna-
dc.contributor.authorKarch, Helge W.-
dc.contributor.authorKlaiber, Bernd-
dc.date.accessioned2014-07-26T23:11:05Z-
dc.date.available2014-07-26T23:11:05Z-
dc.date.issued1998-
dc.identifier.citationJournal of Clinical Periodontology, 1998, v. 25, n. 1, p. 1-10-
dc.identifier.urihttp://hdl.handle.net/10722/200062-
dc.description.abstract48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). Subgingival plaque and swab samples from tongue, tonsils, and buccal mucosa were taken at baseline, 10 days and 3, 6, 9, and 12 months. A. actinomycetemcomitans was detected in the oral cavity, i.e., subgingival plaque and/or mucous membranes, less frequently in test patients compared to controls at 9 and 12 months (p<0.01), whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy (p<0.001). At any time after therapy, A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1 of 13 (8%) control patients harboring this pathogen at baseline; P. gingivalis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months, P. gingivalis persisted or reoccurred. © Munksgaard, 1998.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectChlorhexidine digluconate-
dc.subjectPeriodontitis/therapy-
dc.subjectPorphyromonas gingivalis-
dc.subjectActinobacillus actinomycetemcomitans-
dc.subjectAmoxicillin-
dc.subjectAntibiotics-
dc.subjectMetronidazole-
dc.titleDifferential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.1998.tb02356.x-
dc.identifier.pmid9477013-
dc.identifier.scopuseid_2-s2.0-0031603004-
dc.identifier.volume25-
dc.identifier.issue1-
dc.identifier.spage1-
dc.identifier.epage10-
dc.identifier.isiWOS:000071623900001-

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