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- Publisher Website: 10.1111/j.1600-051X.1998.tb02356.x
- Scopus: eid_2-s2.0-0031603004
- PMID: 9477013
- WOS: WOS:000071623900001
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Article: Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats
Title | Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats |
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Authors | |
Keywords | Chlorhexidine digluconate Periodontitis/therapy Porphyromonas gingivalis Actinobacillus actinomycetemcomitans Amoxicillin Antibiotics Metronidazole |
Issue Date | 1998 |
Citation | Journal of Clinical Periodontology, 1998, v. 25, n. 1, p. 1-10 How to Cite? |
Abstract | 48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). Subgingival plaque and swab samples from tongue, tonsils, and buccal mucosa were taken at baseline, 10 days and 3, 6, 9, and 12 months. A. actinomycetemcomitans was detected in the oral cavity, i.e., subgingival plaque and/or mucous membranes, less frequently in test patients compared to controls at 9 and 12 months (p<0.01), whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy (p<0.001). At any time after therapy, A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1 of 13 (8%) control patients harboring this pathogen at baseline; P. gingivalis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months, P. gingivalis persisted or reoccurred. © Munksgaard, 1998. |
Persistent Identifier | http://hdl.handle.net/10722/200062 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 2.249 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Flemmig, Thomas Frank | - |
dc.contributor.author | Milián, E. | - |
dc.contributor.author | Kopp, Corinna | - |
dc.contributor.author | Karch, Helge W. | - |
dc.contributor.author | Klaiber, Bernd | - |
dc.date.accessioned | 2014-07-26T23:11:05Z | - |
dc.date.available | 2014-07-26T23:11:05Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Journal of Clinical Periodontology, 1998, v. 25, n. 1, p. 1-10 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200062 | - |
dc.description.abstract | 48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). Subgingival plaque and swab samples from tongue, tonsils, and buccal mucosa were taken at baseline, 10 days and 3, 6, 9, and 12 months. A. actinomycetemcomitans was detected in the oral cavity, i.e., subgingival plaque and/or mucous membranes, less frequently in test patients compared to controls at 9 and 12 months (p<0.01), whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy (p<0.001). At any time after therapy, A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1 of 13 (8%) control patients harboring this pathogen at baseline; P. gingivalis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months, P. gingivalis persisted or reoccurred. © Munksgaard, 1998. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Periodontology | - |
dc.subject | Chlorhexidine digluconate | - |
dc.subject | Periodontitis/therapy | - |
dc.subject | Porphyromonas gingivalis | - |
dc.subject | Actinobacillus actinomycetemcomitans | - |
dc.subject | Amoxicillin | - |
dc.subject | Antibiotics | - |
dc.subject | Metronidazole | - |
dc.title | Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1600-051X.1998.tb02356.x | - |
dc.identifier.pmid | 9477013 | - |
dc.identifier.scopus | eid_2-s2.0-0031603004 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 10 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.isi | WOS:000071623900001 | - |
dc.identifier.issnl | 0303-6979 | - |