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Article: Efficacy of systemically administered acetylsalicylic acid plus scaling on periodontal health and elastase-α1-proteinase inhibitor in gingival crevicular fluid

TitleEfficacy of systemically administered acetylsalicylic acid plus scaling on periodontal health and elastase-α1-proteinase inhibitor in gingival crevicular fluid
Authors
KeywordsNon-steroidal anti-inflammatory drugs
Therapy
Gingival crevicular fluid
Scaling
Periodontitis
Acetylsalicylic acid
Elastase
Issue Date1996
Citation
Journal of Clinical Periodontology, 1996, v. 23, n. 3 PART I, p. 153-159 How to Cite?
AbstractThe purpose of this proof of principle trial was to assess whether conventional periodontal therapy and systemically administrated acetylsalicylic acid (ASA) are functionally synergistic when combined in the treatment of periodontitis. A total of 30 patients with untreated moderate to severe adult periodontitis were enrolled into the study and were given placebo q.i.d. between the baseline and 6-week examination, and acetylsalicylic acid (ASA) 500 mg q.i.d. between the 6-week and 12-week examinations. In addition, they received supraand subgingival scaling in 1 quadrant after baseline examination and in 2 further randomly selected quadrants after the 6-week examination. The study design resulted in the following 4 therapies: (1) scaling plus ASA 500 mg q.i.d.; (2) scaling plus placebo q.i.d.; (3) ASA 500 mg q.i.d. alone; (4) placebo q.i.d. alone. Two-way analysis of variance showed functional synergism of ASA and scaling, resulting in a therapeutic efficacy approximately equivalent to the sum of each individual therapeutic efficacy (i.e., ASA alone and scaling alone) in reducing gingival inflammation and pocket probing depth over the 6-week observation period (interaction: p>0.05). Only the effect of ASA was significant in reducing the concentration of elastase-α1-proteinase inhibitor in gingival crevicular fluid (GCF E-α1-PI) (p<0.001), reduction in GCF E-α1-PI concentrations by ASA may indicate a decreased risk in periodontal disease progression. The results suggest that the combination of therapies and their different mechanisms of action, i.e., reduction of bacterial plaque and inhibition of destructive components of the immune responses, may result in functionally synergistic therapeutic efficacies in patients with untreated adult periodontitis. © Munksgaard, 1996.
Persistent Identifierhttp://hdl.handle.net/10722/200055
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFlemmig, Thomas Frank-
dc.date.accessioned2014-07-26T23:11:04Z-
dc.date.available2014-07-26T23:11:04Z-
dc.date.issued1996-
dc.identifier.citationJournal of Clinical Periodontology, 1996, v. 23, n. 3 PART I, p. 153-159-
dc.identifier.urihttp://hdl.handle.net/10722/200055-
dc.description.abstractThe purpose of this proof of principle trial was to assess whether conventional periodontal therapy and systemically administrated acetylsalicylic acid (ASA) are functionally synergistic when combined in the treatment of periodontitis. A total of 30 patients with untreated moderate to severe adult periodontitis were enrolled into the study and were given placebo q.i.d. between the baseline and 6-week examination, and acetylsalicylic acid (ASA) 500 mg q.i.d. between the 6-week and 12-week examinations. In addition, they received supraand subgingival scaling in 1 quadrant after baseline examination and in 2 further randomly selected quadrants after the 6-week examination. The study design resulted in the following 4 therapies: (1) scaling plus ASA 500 mg q.i.d.; (2) scaling plus placebo q.i.d.; (3) ASA 500 mg q.i.d. alone; (4) placebo q.i.d. alone. Two-way analysis of variance showed functional synergism of ASA and scaling, resulting in a therapeutic efficacy approximately equivalent to the sum of each individual therapeutic efficacy (i.e., ASA alone and scaling alone) in reducing gingival inflammation and pocket probing depth over the 6-week observation period (interaction: p>0.05). Only the effect of ASA was significant in reducing the concentration of elastase-α1-proteinase inhibitor in gingival crevicular fluid (GCF E-α1-PI) (p<0.001), reduction in GCF E-α1-PI concentrations by ASA may indicate a decreased risk in periodontal disease progression. The results suggest that the combination of therapies and their different mechanisms of action, i.e., reduction of bacterial plaque and inhibition of destructive components of the immune responses, may result in functionally synergistic therapeutic efficacies in patients with untreated adult periodontitis. © Munksgaard, 1996.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectNon-steroidal anti-inflammatory drugs-
dc.subjectTherapy-
dc.subjectGingival crevicular fluid-
dc.subjectScaling-
dc.subjectPeriodontitis-
dc.subjectAcetylsalicylic acid-
dc.subjectElastase-
dc.titleEfficacy of systemically administered acetylsalicylic acid plus scaling on periodontal health and elastase-α1-proteinase inhibitor in gingival crevicular fluid-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.1996.tb02070.x-
dc.identifier.pmid8707972-
dc.identifier.scopuseid_2-s2.0-0030096040-
dc.identifier.volume23-
dc.identifier.issue3 PART I-
dc.identifier.spage153-
dc.identifier.epage159-
dc.identifier.isiWOS:A1996UC39500002-

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