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Article: The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis

TitleThe role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
Authors
Issue Date1996
Citation
Nature Medicine, 1996, v. 2, n. 2, p. 175-182 How to Cite?
AbstractInterleukin 15 (IL-15) is a novel cytokine with interleukin-2-like activity. It is also a potent T-lymphocyte chemoattractant. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the presence of activated T lymphocytes, macrophages and synoviocytes in the synovial membrane. The mechanisms of T-cell activation in RA are currently unclear. We report the presence of high concentrations of IL-15 in rheumatoid arthritis (RA) synovial fluid and have demonstrated its expression in the synovial membrane lining layer by immunohistochemistry. RA synovial fluids were found to contain chemotactic activity, which was attributable in part to the presence of IL-15. Moreover, in a murine model, injection of recombinant IL-15 was found to induce a local tissue inflammatory infiltrate consisting predominantly of T lymphocytes. Synovial fluid T lymphocytes proliferate in response to IL-15, demonstrating that continued responsiveness to IL-15 is a feature of T cells after entry into the synovial compartment. These data suggest that IL-15 can recruit and activate T lymphocytes into the synovial membrane, thereby contributing to RA pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/200054
ISSN
2015 Impact Factor: 30.357
2015 SCImago Journal Rankings: 13.959
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMcInnes, Iain B.-
dc.contributor.authorAl-Mughales, Jamil A.-
dc.contributor.authorField, Max H.-
dc.contributor.authorLeung, Bernard-
dc.contributor.authorHuang, Fangping-
dc.contributor.authorDixon, Richard J.-
dc.contributor.authorSturrock, Roger D.-
dc.contributor.authorWilkinson, Peter C.-
dc.contributor.authorLiew, Fooyew-
dc.date.accessioned2014-07-26T23:11:04Z-
dc.date.available2014-07-26T23:11:04Z-
dc.date.issued1996-
dc.identifier.citationNature Medicine, 1996, v. 2, n. 2, p. 175-182-
dc.identifier.issn1078-8956-
dc.identifier.urihttp://hdl.handle.net/10722/200054-
dc.description.abstractInterleukin 15 (IL-15) is a novel cytokine with interleukin-2-like activity. It is also a potent T-lymphocyte chemoattractant. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the presence of activated T lymphocytes, macrophages and synoviocytes in the synovial membrane. The mechanisms of T-cell activation in RA are currently unclear. We report the presence of high concentrations of IL-15 in rheumatoid arthritis (RA) synovial fluid and have demonstrated its expression in the synovial membrane lining layer by immunohistochemistry. RA synovial fluids were found to contain chemotactic activity, which was attributable in part to the presence of IL-15. Moreover, in a murine model, injection of recombinant IL-15 was found to induce a local tissue inflammatory infiltrate consisting predominantly of T lymphocytes. Synovial fluid T lymphocytes proliferate in response to IL-15, demonstrating that continued responsiveness to IL-15 is a feature of T cells after entry into the synovial compartment. These data suggest that IL-15 can recruit and activate T lymphocytes into the synovial membrane, thereby contributing to RA pathogenesis.-
dc.languageeng-
dc.relation.ispartofNature Medicine-
dc.titleThe role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nm0296-175-
dc.identifier.pmid8574962-
dc.identifier.scopuseid_2-s2.0-0030022275-
dc.identifier.volume2-
dc.identifier.issue2-
dc.identifier.spage175-
dc.identifier.epage182-
dc.identifier.isiWOS:A1996TU06000037-

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