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Article: Efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis

TitleEfficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis
Authors
KeywordsPeriodontitis
Periodontal diseases
Moxifloxacin
Dental scaling
Biofilms
Anti-bacterial agents
Issue Date2011
Citation
Journal of Periodontology, 2011, v. 82, n. 1, p. 96-105 How to Cite?
AbstractBackground: Moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. Methods: Patients with chronic periodontitis were randomly assigned to receive a single subgingival application of a 0.125%, 0.4%, or 1.25% moxifloxacin gel or placebo gel immediately after full-mouth scaling and root planing (SRP). Clinical efficacy measurements were assessed in sites with baseline probing depth (PD) of ≥5.4 mm at 6 weeks and 3 months and any adverse events were determined. In addition, putative periodontal pathogens and resistance of subgingival bacteria against moxifloxacin were assessed. Results: Data of 57 patients were included in the statistical analysis. In all treatment groups, the PD decreased from baseline to 3 months, with the greatest reduction seen in patients treated with moxifloxacin 0.4% (1.5 ± 0.6 mm; P = 0.023 compared to placebo), followed by patients receiving moxifloxacin 1.25% (1.2 ± 0.4), moxifloxacin 0.125% (1.1 ± 1.1), and placebo (1.0 ± 0.6). No linear trend for PD reduction with increasing moxifloxacin concentrations was found. Porphyromonas gingivalis showed the greatest reduction in prevalence among the assessed pathogens, without any significant intergroup differences. No correlation or systematic relationship between adverse events, including bacterial resistance against moxifloxacin, and the investigational gels was found. Conclusions: In periodontal pockets with PD of ≥5.4 mm, a single subgingival administration of a 0.4% moxifloxacin gel as an adjunct to SRP may result in additional PD reduction compared to SRP alone. In addition, the investigated moxifloxacin gels seem to be safe.
Persistent Identifierhttp://hdl.handle.net/10722/200011
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFlemmig, Thomas Frank-
dc.contributor.authorPetersilka, Gregor J.-
dc.contributor.authorVölp, Andreas-
dc.contributor.authorGravemeier, Martina-
dc.contributor.authorZilly, Martin-
dc.contributor.authorMross, Daniela-
dc.contributor.authorPrior, Karola-
dc.contributor.authorYamamoto, Julie-
dc.contributor.authorBeikleri, Thomas-
dc.date.accessioned2014-07-26T23:11:01Z-
dc.date.available2014-07-26T23:11:01Z-
dc.date.issued2011-
dc.identifier.citationJournal of Periodontology, 2011, v. 82, n. 1, p. 96-105-
dc.identifier.issn0022-3492-
dc.identifier.urihttp://hdl.handle.net/10722/200011-
dc.description.abstractBackground: Moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. Methods: Patients with chronic periodontitis were randomly assigned to receive a single subgingival application of a 0.125%, 0.4%, or 1.25% moxifloxacin gel or placebo gel immediately after full-mouth scaling and root planing (SRP). Clinical efficacy measurements were assessed in sites with baseline probing depth (PD) of ≥5.4 mm at 6 weeks and 3 months and any adverse events were determined. In addition, putative periodontal pathogens and resistance of subgingival bacteria against moxifloxacin were assessed. Results: Data of 57 patients were included in the statistical analysis. In all treatment groups, the PD decreased from baseline to 3 months, with the greatest reduction seen in patients treated with moxifloxacin 0.4% (1.5 ± 0.6 mm; P = 0.023 compared to placebo), followed by patients receiving moxifloxacin 1.25% (1.2 ± 0.4), moxifloxacin 0.125% (1.1 ± 1.1), and placebo (1.0 ± 0.6). No linear trend for PD reduction with increasing moxifloxacin concentrations was found. Porphyromonas gingivalis showed the greatest reduction in prevalence among the assessed pathogens, without any significant intergroup differences. No correlation or systematic relationship between adverse events, including bacterial resistance against moxifloxacin, and the investigational gels was found. Conclusions: In periodontal pockets with PD of ≥5.4 mm, a single subgingival administration of a 0.4% moxifloxacin gel as an adjunct to SRP may result in additional PD reduction compared to SRP alone. In addition, the investigated moxifloxacin gels seem to be safe.-
dc.languageeng-
dc.relation.ispartofJournal of Periodontology-
dc.subjectPeriodontitis-
dc.subjectPeriodontal diseases-
dc.subjectMoxifloxacin-
dc.subjectDental scaling-
dc.subjectBiofilms-
dc.subjectAnti-bacterial agents-
dc.titleEfficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1902/jop.2010.100124-
dc.identifier.pmid20843236-
dc.identifier.scopuseid_2-s2.0-79251610898-
dc.identifier.volume82-
dc.identifier.issue1-
dc.identifier.spage96-
dc.identifier.epage105-
dc.identifier.isiWOS:000286347900011-

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