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- Publisher Website: 10.1902/jop.2010.100124
- Scopus: eid_2-s2.0-79251610898
- PMID: 20843236
- WOS: WOS:000286347900011
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Article: Efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis
Title | Efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis |
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Authors | |
Keywords | Periodontitis Periodontal diseases Moxifloxacin Dental scaling Biofilms Anti-bacterial agents |
Issue Date | 2011 |
Citation | Journal of Periodontology, 2011, v. 82, n. 1, p. 96-105 How to Cite? |
Abstract | Background: Moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. Methods: Patients with chronic periodontitis were randomly assigned to receive a single subgingival application of a 0.125%, 0.4%, or 1.25% moxifloxacin gel or placebo gel immediately after full-mouth scaling and root planing (SRP). Clinical efficacy measurements were assessed in sites with baseline probing depth (PD) of ≥5.4 mm at 6 weeks and 3 months and any adverse events were determined. In addition, putative periodontal pathogens and resistance of subgingival bacteria against moxifloxacin were assessed. Results: Data of 57 patients were included in the statistical analysis. In all treatment groups, the PD decreased from baseline to 3 months, with the greatest reduction seen in patients treated with moxifloxacin 0.4% (1.5 ± 0.6 mm; P = 0.023 compared to placebo), followed by patients receiving moxifloxacin 1.25% (1.2 ± 0.4), moxifloxacin 0.125% (1.1 ± 1.1), and placebo (1.0 ± 0.6). No linear trend for PD reduction with increasing moxifloxacin concentrations was found. Porphyromonas gingivalis showed the greatest reduction in prevalence among the assessed pathogens, without any significant intergroup differences. No correlation or systematic relationship between adverse events, including bacterial resistance against moxifloxacin, and the investigational gels was found. Conclusions: In periodontal pockets with PD of ≥5.4 mm, a single subgingival administration of a 0.4% moxifloxacin gel as an adjunct to SRP may result in additional PD reduction compared to SRP alone. In addition, the investigated moxifloxacin gels seem to be safe. |
Persistent Identifier | http://hdl.handle.net/10722/200011 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.362 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Flemmig, Thomas Frank | - |
dc.contributor.author | Petersilka, Gregor J. | - |
dc.contributor.author | Völp, Andreas | - |
dc.contributor.author | Gravemeier, Martina | - |
dc.contributor.author | Zilly, Martin | - |
dc.contributor.author | Mross, Daniela | - |
dc.contributor.author | Prior, Karola | - |
dc.contributor.author | Yamamoto, Julie | - |
dc.contributor.author | Beikleri, Thomas | - |
dc.date.accessioned | 2014-07-26T23:11:01Z | - |
dc.date.available | 2014-07-26T23:11:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of Periodontology, 2011, v. 82, n. 1, p. 96-105 | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | http://hdl.handle.net/10722/200011 | - |
dc.description.abstract | Background: Moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. Methods: Patients with chronic periodontitis were randomly assigned to receive a single subgingival application of a 0.125%, 0.4%, or 1.25% moxifloxacin gel or placebo gel immediately after full-mouth scaling and root planing (SRP). Clinical efficacy measurements were assessed in sites with baseline probing depth (PD) of ≥5.4 mm at 6 weeks and 3 months and any adverse events were determined. In addition, putative periodontal pathogens and resistance of subgingival bacteria against moxifloxacin were assessed. Results: Data of 57 patients were included in the statistical analysis. In all treatment groups, the PD decreased from baseline to 3 months, with the greatest reduction seen in patients treated with moxifloxacin 0.4% (1.5 ± 0.6 mm; P = 0.023 compared to placebo), followed by patients receiving moxifloxacin 1.25% (1.2 ± 0.4), moxifloxacin 0.125% (1.1 ± 1.1), and placebo (1.0 ± 0.6). No linear trend for PD reduction with increasing moxifloxacin concentrations was found. Porphyromonas gingivalis showed the greatest reduction in prevalence among the assessed pathogens, without any significant intergroup differences. No correlation or systematic relationship between adverse events, including bacterial resistance against moxifloxacin, and the investigational gels was found. Conclusions: In periodontal pockets with PD of ≥5.4 mm, a single subgingival administration of a 0.4% moxifloxacin gel as an adjunct to SRP may result in additional PD reduction compared to SRP alone. In addition, the investigated moxifloxacin gels seem to be safe. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Periodontology | - |
dc.subject | Periodontitis | - |
dc.subject | Periodontal diseases | - |
dc.subject | Moxifloxacin | - |
dc.subject | Dental scaling | - |
dc.subject | Biofilms | - |
dc.subject | Anti-bacterial agents | - |
dc.title | Efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1902/jop.2010.100124 | - |
dc.identifier.pmid | 20843236 | - |
dc.identifier.scopus | eid_2-s2.0-79251610898 | - |
dc.identifier.volume | 82 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 96 | - |
dc.identifier.epage | 105 | - |
dc.identifier.isi | WOS:000286347900011 | - |
dc.identifier.issnl | 0022-3492 | - |