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Article: Caspase activation is involved in chronic periodontitis

TitleCaspase activation is involved in chronic periodontitis
Authors
KeywordsPARP
Periodontitis
Apoptosis
Caspases
CD95
Issue Date2005
Citation
FEBS Letters, 2005, v. 579, n. 25, p. 559-5564 How to Cite?
AbstractPeriodontitis, a common infectious disease, is initiated by various gram-negative bacteria and characterized by the destruction of the periodontal tissue. Here, we investigated the role of caspases, intracellular proteases that are the key mediators of apoptosis. We show that activation of caspase-3 and caspase-7 is considerably enhanced in gingival tissue from patients with periodontitis. We also demonstrate in in vitro experiments that various periodontopathic bacteria exert a direct growth-suppressing effect and, moreover, can trigger a host-mediated cytotoxic activity involving the CD95 death receptor. Our data suggest that caspase activation is a prominent feature in periodontitis-associated tissue injury. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/199945
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBantel, Heike-
dc.contributor.authorBeikler, Thomas-
dc.contributor.authorFlemmig, Thomas Frank-
dc.contributor.authorSchulze- Osthoff, Klaus-
dc.date.accessioned2014-07-26T23:10:56Z-
dc.date.available2014-07-26T23:10:56Z-
dc.date.issued2005-
dc.identifier.citationFEBS Letters, 2005, v. 579, n. 25, p. 559-5564-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10722/199945-
dc.description.abstractPeriodontitis, a common infectious disease, is initiated by various gram-negative bacteria and characterized by the destruction of the periodontal tissue. Here, we investigated the role of caspases, intracellular proteases that are the key mediators of apoptosis. We show that activation of caspase-3 and caspase-7 is considerably enhanced in gingival tissue from patients with periodontitis. We also demonstrate in in vitro experiments that various periodontopathic bacteria exert a direct growth-suppressing effect and, moreover, can trigger a host-mediated cytotoxic activity involving the CD95 death receptor. Our data suggest that caspase activation is a prominent feature in periodontitis-associated tissue injury. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.-
dc.languageeng-
dc.relation.ispartofFEBS Letters-
dc.subjectPARP-
dc.subjectPeriodontitis-
dc.subjectApoptosis-
dc.subjectCaspases-
dc.subjectCD95-
dc.titleCaspase activation is involved in chronic periodontitis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2005.09.020-
dc.identifier.pmid16213496-
dc.identifier.scopuseid_2-s2.0-26844484704-
dc.identifier.volume579-
dc.identifier.issue25-
dc.identifier.spage559-
dc.identifier.epage5564-
dc.identifier.isiWOS:000232824200020-

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