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- Publisher Website: 10.1016/j.febslet.2005.09.020
- Scopus: eid_2-s2.0-26844484704
- PMID: 16213496
- WOS: WOS:000232824200020
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Article: Caspase activation is involved in chronic periodontitis
Title | Caspase activation is involved in chronic periodontitis |
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Authors | |
Keywords | PARP Periodontitis Apoptosis Caspases CD95 |
Issue Date | 2005 |
Citation | FEBS Letters, 2005, v. 579, n. 25, p. 559-5564 How to Cite? |
Abstract | Periodontitis, a common infectious disease, is initiated by various gram-negative bacteria and characterized by the destruction of the periodontal tissue. Here, we investigated the role of caspases, intracellular proteases that are the key mediators of apoptosis. We show that activation of caspase-3 and caspase-7 is considerably enhanced in gingival tissue from patients with periodontitis. We also demonstrate in in vitro experiments that various periodontopathic bacteria exert a direct growth-suppressing effect and, moreover, can trigger a host-mediated cytotoxic activity involving the CD95 death receptor. Our data suggest that caspase activation is a prominent feature in periodontitis-associated tissue injury. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. |
Persistent Identifier | http://hdl.handle.net/10722/199945 |
ISSN | 2021 Impact Factor: 3.864 2020 SCImago Journal Rankings: 1.593 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bantel, Heike | - |
dc.contributor.author | Beikler, Thomas | - |
dc.contributor.author | Flemmig, Thomas Frank | - |
dc.contributor.author | Schulze- Osthoff, Klaus | - |
dc.date.accessioned | 2014-07-26T23:10:56Z | - |
dc.date.available | 2014-07-26T23:10:56Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | FEBS Letters, 2005, v. 579, n. 25, p. 559-5564 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10722/199945 | - |
dc.description.abstract | Periodontitis, a common infectious disease, is initiated by various gram-negative bacteria and characterized by the destruction of the periodontal tissue. Here, we investigated the role of caspases, intracellular proteases that are the key mediators of apoptosis. We show that activation of caspase-3 and caspase-7 is considerably enhanced in gingival tissue from patients with periodontitis. We also demonstrate in in vitro experiments that various periodontopathic bacteria exert a direct growth-suppressing effect and, moreover, can trigger a host-mediated cytotoxic activity involving the CD95 death receptor. Our data suggest that caspase activation is a prominent feature in periodontitis-associated tissue injury. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. | - |
dc.language | eng | - |
dc.relation.ispartof | FEBS Letters | - |
dc.subject | PARP | - |
dc.subject | Periodontitis | - |
dc.subject | Apoptosis | - |
dc.subject | Caspases | - |
dc.subject | CD95 | - |
dc.title | Caspase activation is involved in chronic periodontitis | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.febslet.2005.09.020 | - |
dc.identifier.pmid | 16213496 | - |
dc.identifier.scopus | eid_2-s2.0-26844484704 | - |
dc.identifier.volume | 579 | - |
dc.identifier.issue | 25 | - |
dc.identifier.spage | 559 | - |
dc.identifier.epage | 5564 | - |
dc.identifier.isi | WOS:000232824200020 | - |
dc.identifier.issnl | 0014-5793 | - |