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Article: Multifactorial assessment of predictors for prevention of periodontal disease progression.

TitleMultifactorial assessment of predictors for prevention of periodontal disease progression.
Authors
Issue Date2003
Citation
Clinical oral investigations, 2003, v. 7, n. 4, p. 217-221 How to Cite?
AbstractUnivariate approaches have identified single factors influencing periodontal disease progression. The aim of this explorative approach was to assess the influence of various predictive factors responsible for the prevention of periodontal disease progression in the same patient sample. Patients with untreated chronic periodontitis underwent subgingival debridement alone or in combination with adjunctive antimicrobial therapy (systemic amoxicillin and metronidazole/7 days plus supragingival CHX irrigation). Supportive periodontal therapy was performed over a 24-month period. As predictors, clinical, microbial, immunological, and genetic parameters were assessed. The primary outcome variable was the percentage of teeth without attachment loss >/=2 mm over the study period (stability of attachment). At 24 months, multiple regression analysis identified adjunctive antimicrobial therapy for teeth with initially at least one site showing a pocket probing depth of >/=7 mm and IgG(4) reactivity against a 110-kDa protein of A. actinomycetemcomitans at teeth with initial pocket probing depths
Persistent Identifierhttp://hdl.handle.net/10722/199902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorEhmke, Benjamin-
dc.contributor.authorBeikler, Thomas-
dc.contributor.authorHaubitz, Imme-
dc.contributor.authorKarch, Helge W.-
dc.contributor.authorFlemmig, Thomas Frank-
dc.date.accessioned2014-07-26T23:10:53Z-
dc.date.available2014-07-26T23:10:53Z-
dc.date.issued2003-
dc.identifier.citationClinical oral investigations, 2003, v. 7, n. 4, p. 217-221-
dc.identifier.urihttp://hdl.handle.net/10722/199902-
dc.description.abstractUnivariate approaches have identified single factors influencing periodontal disease progression. The aim of this explorative approach was to assess the influence of various predictive factors responsible for the prevention of periodontal disease progression in the same patient sample. Patients with untreated chronic periodontitis underwent subgingival debridement alone or in combination with adjunctive antimicrobial therapy (systemic amoxicillin and metronidazole/7 days plus supragingival CHX irrigation). Supportive periodontal therapy was performed over a 24-month period. As predictors, clinical, microbial, immunological, and genetic parameters were assessed. The primary outcome variable was the percentage of teeth without attachment loss >/=2 mm over the study period (stability of attachment). At 24 months, multiple regression analysis identified adjunctive antimicrobial therapy for teeth with initially at least one site showing a pocket probing depth of >/=7 mm and IgG(4) reactivity against a 110-kDa protein of A. actinomycetemcomitans at teeth with initial pocket probing depths </=6 mm as main predictors of long-term attachment stability ( p<0.05). Other parameters failed to influence treatment outcome. Adjunctive antimicrobial therapy and antibody reactivity may be dominant factors influencing the prevention of attachment loss in patients receiving periodontal therapy.-
dc.languageeng-
dc.relation.ispartofClinical oral investigations-
dc.titleMultifactorial assessment of predictors for prevention of periodontal disease progression.-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00784-003-0227-2-
dc.identifier.pmid12942352-
dc.identifier.scopuseid_2-s2.0-1542780648-
dc.identifier.volume7-
dc.identifier.issue4-
dc.identifier.spage217-
dc.identifier.epage221-
dc.identifier.isiWOS:000208381200006-

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