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- Publisher Website: 10.1196/annals.1309.010
- Scopus: eid_2-s2.0-14544271343
- PMID: 15681746
- WOS: WOS:000227728600010
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Conference Paper: Uptake of antigens from the intestine by dendritic cells
Title | Uptake of antigens from the intestine by dendritic cells |
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Authors | |
Keywords | Lymph Lymph node Rat TSE Antigen uptake Dendritic cell Intestine Migration Peyer's patch Prions Scrapie |
Issue Date | 2004 |
Citation | Annals of the New York Academy of Sciences, 2004, v. 1029, p. 75-82 How to Cite? |
Abstract | The intestinal immune system responds to ingested antigens in a variety of ways, ranging from tolerance to full immunity. How T cells are instructed to make these differential responses is still unclear. Dendritic cells (DCs) sample enteric antigens in the lamina propria and Peyer's patches, and transport them within the patch or to mesenteric nodes where they are presented to lymphocytes. It is probable that DCs also transmit information that influences the outcome of T cell activation, but the nature of this information and the factors in the intestine that regulate DC behavior and properties are far from clear. We have developed a model in the rat that permits analysis of DCs actually in the process of migration from the intestine to mesenteric nodes. In this paper we will review those aspects of our research that relate to antigen uptake and discuss these in the contest of other experimental systems. © 2004 New York Academy of Sciences. |
Description | This journal vol. entitled: Oral Tolerance: New Insights and Prospects for Clinical Application Second conference on oral tolerance |
Persistent Identifier | http://hdl.handle.net/10722/199900 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.416 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | MacPherson, Gordon Gordon | - |
dc.contributor.author | Milling, Simon W F | - |
dc.contributor.author | Yrlid, Ulf | - |
dc.contributor.author | Cousins, Lesley | - |
dc.contributor.author | Turnbull, Emma L. | - |
dc.contributor.author | Huang, Fangping | - |
dc.date.accessioned | 2014-07-26T23:10:53Z | - |
dc.date.available | 2014-07-26T23:10:53Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Annals of the New York Academy of Sciences, 2004, v. 1029, p. 75-82 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | http://hdl.handle.net/10722/199900 | - |
dc.description | This journal vol. entitled: Oral Tolerance: New Insights and Prospects for Clinical Application | - |
dc.description | Second conference on oral tolerance | - |
dc.description.abstract | The intestinal immune system responds to ingested antigens in a variety of ways, ranging from tolerance to full immunity. How T cells are instructed to make these differential responses is still unclear. Dendritic cells (DCs) sample enteric antigens in the lamina propria and Peyer's patches, and transport them within the patch or to mesenteric nodes where they are presented to lymphocytes. It is probable that DCs also transmit information that influences the outcome of T cell activation, but the nature of this information and the factors in the intestine that regulate DC behavior and properties are far from clear. We have developed a model in the rat that permits analysis of DCs actually in the process of migration from the intestine to mesenteric nodes. In this paper we will review those aspects of our research that relate to antigen uptake and discuss these in the contest of other experimental systems. © 2004 New York Academy of Sciences. | - |
dc.language | eng | - |
dc.relation.ispartof | Annals of the New York Academy of Sciences | - |
dc.subject | Lymph | - |
dc.subject | Lymph node | - |
dc.subject | Rat | - |
dc.subject | TSE | - |
dc.subject | Antigen uptake | - |
dc.subject | Dendritic cell | - |
dc.subject | Intestine | - |
dc.subject | Migration | - |
dc.subject | Peyer's patch | - |
dc.subject | Prions | - |
dc.subject | Scrapie | - |
dc.title | Uptake of antigens from the intestine by dendritic cells | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1196/annals.1309.010 | - |
dc.identifier.pmid | 15681746 | - |
dc.identifier.scopus | eid_2-s2.0-14544271343 | - |
dc.identifier.volume | 1029 | - |
dc.identifier.spage | 75 | - |
dc.identifier.epage | 82 | - |
dc.identifier.isi | WOS:000227728600010 | - |
dc.customcontrol.immutable | sml 160704 amended | - |
dc.identifier.issnl | 0077-8923 | - |