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Article: Prevalence of Porphyromonas gingivalis fimA genotypes in Caucasians

TitlePrevalence of Porphyromonas gingivalis fimA genotypes in Caucasians
Authors
KeywordsPeriodontitis
Prevalence
Porphyromonas gingivalis
fimA genotype
Caucasian
Issue Date2003
Citation
European Journal of Oral Sciences, 2003, v. 111, n. 5, p. 390-394 How to Cite?
AbstractThe aim of the present study was to determine the prevalence of Porphyromonas gingivalis fimA genotypes in Caucasian patients with periodontitis. A total of 102 patients harboring P. gingivalis subgingivally were enrolled into the study. Pooled subgingival plaque samples of the six most severely affected sites were taken and analysed by fimA-specific polymerase chain reaction (PCR) and restriction analysis. Moreover, 26 P. gingivalis isolates were analysed by sequence analysis of the fimA gene. Sequence analysis revealed five major fimA genotypes (fimA types I-V) and allowed further subtyping of fimA genotypes II and IV into two subgroups each. The overall prevalences of fimA genotypes as assessed by PCR and restriction analysis among the P. gingivalis-positive patients with periodontitis were: type I, 25.5%; type II, 38.2%; type III, 4.9%; type IV, 18.6%; type V, 3.9%; and non-typable, 6.9%. Two patients were colonized by both type II and type IV, or type III and type IV fimA genotypes, respectively. Patients harboring different fimA genotypes showed no significant difference in severity of periodontal disease, as assessed by pocket probing depth and bleeding on probing following adjustment for smoking habit and age. The results indicate that predominant fimA genotypes in Caucasian periodontitis patients are types I, II, and IV. However, there was no difference in the association of the various fimA genotypes with disease severity.
Persistent Identifierhttp://hdl.handle.net/10722/199898
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBeikler, Thomas-
dc.contributor.authorPeters, Ulrike-
dc.contributor.authorPrajaneh, Seangsome-
dc.contributor.authorPrior, Karola-
dc.contributor.authorEhmke, Benjamin-
dc.contributor.authorFlemmig, Thomas Frank-
dc.date.accessioned2014-07-26T23:10:53Z-
dc.date.available2014-07-26T23:10:53Z-
dc.date.issued2003-
dc.identifier.citationEuropean Journal of Oral Sciences, 2003, v. 111, n. 5, p. 390-394-
dc.identifier.urihttp://hdl.handle.net/10722/199898-
dc.description.abstractThe aim of the present study was to determine the prevalence of Porphyromonas gingivalis fimA genotypes in Caucasian patients with periodontitis. A total of 102 patients harboring P. gingivalis subgingivally were enrolled into the study. Pooled subgingival plaque samples of the six most severely affected sites were taken and analysed by fimA-specific polymerase chain reaction (PCR) and restriction analysis. Moreover, 26 P. gingivalis isolates were analysed by sequence analysis of the fimA gene. Sequence analysis revealed five major fimA genotypes (fimA types I-V) and allowed further subtyping of fimA genotypes II and IV into two subgroups each. The overall prevalences of fimA genotypes as assessed by PCR and restriction analysis among the P. gingivalis-positive patients with periodontitis were: type I, 25.5%; type II, 38.2%; type III, 4.9%; type IV, 18.6%; type V, 3.9%; and non-typable, 6.9%. Two patients were colonized by both type II and type IV, or type III and type IV fimA genotypes, respectively. Patients harboring different fimA genotypes showed no significant difference in severity of periodontal disease, as assessed by pocket probing depth and bleeding on probing following adjustment for smoking habit and age. The results indicate that predominant fimA genotypes in Caucasian periodontitis patients are types I, II, and IV. However, there was no difference in the association of the various fimA genotypes with disease severity.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Oral Sciences-
dc.subjectPeriodontitis-
dc.subjectPrevalence-
dc.subjectPorphyromonas gingivalis-
dc.subjectfimA genotype-
dc.subjectCaucasian-
dc.titlePrevalence of Porphyromonas gingivalis fimA genotypes in Caucasians-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1600-0722.2003.00065.x-
dc.identifier.pmid12974681-
dc.identifier.scopuseid_2-s2.0-0344583794-
dc.identifier.volume111-
dc.identifier.issue5-
dc.identifier.spage390-
dc.identifier.epage394-
dc.identifier.isiWOS:000185369900005-

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