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Article: Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus

TitleAntibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus
Authors
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/
Citation
Virology Journal, 2014, v. 11, article no. 82 How to Cite?
AbstractPublic health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recombinant, full-length SARS-CoV Spike-protein trimers, trigger infection of immune cell lines. These observations prompted us to investigate the molecular mechanisms and responses to antibody-mediated infection in human macrophages.
Persistent Identifierhttp://hdl.handle.net/10722/199800
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYip, MSen_US
dc.contributor.authorLEUNG, HLen_US
dc.contributor.authorCheung, CYen_US
dc.contributor.authorLi, PHen_US
dc.contributor.authorLee, HYHen_US
dc.contributor.authorDaëron, Men_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorBruzzone, Ren_US
dc.contributor.authorJaume, MDAen_US
dc.date.accessioned2014-07-22T01:38:29Z-
dc.date.available2014-07-22T01:38:29Z-
dc.date.issued2014en_US
dc.identifier.citationVirology Journal, 2014, v. 11, article no. 82en_US
dc.identifier.otherPMC4018502-
dc.identifier.urihttp://hdl.handle.net/10722/199800-
dc.description.abstractPublic health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recombinant, full-length SARS-CoV Spike-protein trimers, trigger infection of immune cell lines. These observations prompted us to investigate the molecular mechanisms and responses to antibody-mediated infection in human macrophages.en_US
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/-
dc.relation.ispartofVirology Journalen_US
dc.rightsVirology Journal. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAntibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirusen_US
dc.typeArticleen_US
dc.identifier.emailYip, MS: simonyms@graduate.hku.hken_US
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_US
dc.identifier.emailLi, PH: phli@hkucc.hku.hken_US
dc.identifier.emailLee, HYH: horlee@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_US
dc.identifier.emailJaume, MDA: breizh@hku.hken_US
dc.identifier.authorityCheung, CY=rp00404en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityBruzzone, R=rp01442en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1743-422X-11-82en_US
dc.identifier.pmid24885320-
dc.identifier.hkuros230784en_US
dc.identifier.volume11en_US
dc.identifier.isiWOS:000335858400001-

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