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Article: Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes

TitleUse of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes
Authors
Issue Date2014
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1
Citation
Influenza and other respiratory viruses, 2014, v. 8 n. 5, p. 580-584 How to Cite?
AbstractAvian H7N9 influenza viruses may pose a further threat to humans by reassortment with human viruses, which could lead to generation of novel reassortants with enhanced polymerase activity. We previously established a novel statistical approach to study the polymerase activity of reassorted vRNPs (Influenza Other Respir Viruses. 2013;7:969-78). Here, we report the use of this method to study recombinant vRNPs with subunits derived from human H1N1, H3N2, and H7N9 viruses. Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild-type levels.
Persistent Identifierhttp://hdl.handle.net/10722/199796
ISSN
2015 Impact Factor: 2.378
2015 SCImago Journal Rankings: 1.570
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorChin, AWHen_US
dc.contributor.authorMok, CKPen_US
dc.contributor.authorZhu, Hen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorPoon, LLMen_US
dc.date.accessioned2014-07-22T01:38:27Z-
dc.date.available2014-07-22T01:38:27Z-
dc.date.issued2014-
dc.identifier.citationInfluenza and other respiratory viruses, 2014, v. 8 n. 5, p. 580-584en_US
dc.identifier.issn1750-2640-
dc.identifier.urihttp://hdl.handle.net/10722/199796-
dc.description.abstractAvian H7N9 influenza viruses may pose a further threat to humans by reassortment with human viruses, which could lead to generation of novel reassortants with enhanced polymerase activity. We previously established a novel statistical approach to study the polymerase activity of reassorted vRNPs (Influenza Other Respir Viruses. 2013;7:969-78). Here, we report the use of this method to study recombinant vRNPs with subunits derived from human H1N1, H3N2, and H7N9 viruses. Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild-type levels.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1-
dc.relation.ispartofInfluenza and other respiratory virusesen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleUse of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypesen_US
dc.typeArticleen_US
dc.identifier.emailChin, AWH: alexchin@hku.hken_US
dc.identifier.emailMok, CKP: ch02mkp@hkucc.hku.hken_US
dc.identifier.emailZhu, H: zhuhch@hku.hken_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.authorityMok, CKP=rp01805en_US
dc.identifier.authorityZhu, H=rp01535en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/irv.12269-
dc.identifier.pmid25043276-
dc.identifier.pmcidPMC4161617-
dc.identifier.hkuros230149en_US
dc.identifier.volume8-
dc.identifier.issue5-
dc.identifier.spage580-
dc.identifier.epage584-
dc.publisher.placeUnited Kingdom-

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