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- Publisher Website: 10.1111/irv.12269
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- PMID: 25043276
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Article: Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes
Title | Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes |
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Authors | |
Keywords | Fractional factorial design H7N9 Influenza polymerase |
Issue Date | 2014 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1 |
Citation | Influenza and other respiratory viruses, 2014, v. 8 n. 5, p. 580-584 How to Cite? |
Abstract | Avian H7N9 influenza viruses may pose a further threat to humans by reassortment with human viruses, which could lead to generation of novel reassortants with enhanced polymerase activity. We previously established a novel statistical approach to study the polymerase activity of reassorted vRNPs (Influenza Other Respir Viruses. 2013;7:969-78). Here, we report the use of this method to study recombinant vRNPs with subunits derived from human H1N1, H3N2, and H7N9 viruses. Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild-type levels. |
Persistent Identifier | http://hdl.handle.net/10722/199796 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.485 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chin, AWH | en_US |
dc.contributor.author | Mok, CKP | en_US |
dc.contributor.author | Zhu, H | en_US |
dc.contributor.author | Guan, Y | en_US |
dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Poon, LLM | en_US |
dc.date.accessioned | 2014-07-22T01:38:27Z | - |
dc.date.available | 2014-07-22T01:38:27Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Influenza and other respiratory viruses, 2014, v. 8 n. 5, p. 580-584 | en_US |
dc.identifier.issn | 1750-2640 | - |
dc.identifier.uri | http://hdl.handle.net/10722/199796 | - |
dc.description.abstract | Avian H7N9 influenza viruses may pose a further threat to humans by reassortment with human viruses, which could lead to generation of novel reassortants with enhanced polymerase activity. We previously established a novel statistical approach to study the polymerase activity of reassorted vRNPs (Influenza Other Respir Viruses. 2013;7:969-78). Here, we report the use of this method to study recombinant vRNPs with subunits derived from human H1N1, H3N2, and H7N9 viruses. Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild-type levels. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1 | - |
dc.relation.ispartof | Influenza and other respiratory viruses | en_US |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Fractional factorial design | - |
dc.subject | H7N9 | - |
dc.subject | Influenza polymerase | - |
dc.title | Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chin, AWH: alexchin@hku.hk | en_US |
dc.identifier.email | Mok, CKP: ch02mkp@hkucc.hku.hk | en_US |
dc.identifier.email | Zhu, H: zhuhch@hku.hk | en_US |
dc.identifier.email | Guan, Y: yguan@hkucc.hku.hk | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.email | Poon, LLM: llmpoon@hkucc.hku.hk | en_US |
dc.identifier.authority | Mok, CKP=rp01805 | en_US |
dc.identifier.authority | Zhu, H=rp01535 | en_US |
dc.identifier.authority | Guan, Y=rp00397 | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.identifier.authority | Poon, LLM=rp00484 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/irv.12269 | - |
dc.identifier.pmid | 25043276 | - |
dc.identifier.pmcid | PMC4161617 | - |
dc.identifier.scopus | eid_2-s2.0-84908023750 | - |
dc.identifier.hkuros | 230149 | en_US |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 580 | - |
dc.identifier.epage | 584 | - |
dc.identifier.isi | WOS:000342067200011 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1750-2640 | - |