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Conference Paper: A powerful parent-of-origin effects test for qualitative traits incorporating unaffected children in nuclear familes

TitleA powerful parent-of-origin effects test for qualitative traits incorporating unaffected children in nuclear familes
Authors
Issue Date2013
Citation
The 9th International Conference of the International Chinese Statistical Association (ICSA), Hong Kong, China, 20-23 December 2013 How to Cite?
AbstractGenomic imprinting is an important epigenetic phenomenon in studying complex traits and has generally been examined by detecting parent-of-origin effects of alleles. The parental-asymmetry test based on nuclear families with both parents and its extensions to deal with missing parental genotypes are simple and powerful for such a task. However, these methods only use case (affected) children in nuclear families and thus do not make full use of information on control (unaffected) children, if available, in these families. In this talk, we propose a novel parent-of-origin effects test C-PATu by using both the control and case children in nuclear families with one or both parents. C-PATu is essentially constructed under a weighted framework, in which the test based on all the unaffected children …
DescriptionInvited
Persistent Identifierhttp://hdl.handle.net/10722/199492

 

DC FieldValueLanguage
dc.contributor.authorFung, WKen_US
dc.date.accessioned2014-07-22T01:20:47Z-
dc.date.available2014-07-22T01:20:47Z-
dc.date.issued2013en_US
dc.identifier.citationThe 9th International Conference of the International Chinese Statistical Association (ICSA), Hong Kong, China, 20-23 December 2013en_US
dc.identifier.urihttp://hdl.handle.net/10722/199492-
dc.descriptionInvited-
dc.description.abstractGenomic imprinting is an important epigenetic phenomenon in studying complex traits and has generally been examined by detecting parent-of-origin effects of alleles. The parental-asymmetry test based on nuclear families with both parents and its extensions to deal with missing parental genotypes are simple and powerful for such a task. However, these methods only use case (affected) children in nuclear families and thus do not make full use of information on control (unaffected) children, if available, in these families. In this talk, we propose a novel parent-of-origin effects test C-PATu by using both the control and case children in nuclear families with one or both parents. C-PATu is essentially constructed under a weighted framework, in which the test based on all the unaffected children …-
dc.languageengen_US
dc.relation.ispartofInternational Chinese Statistical Association (ICSA) International Conferenceen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleA powerful parent-of-origin effects test for qualitative traits incorporating unaffected children in nuclear familesen_US
dc.typeConference_Paperen_US
dc.identifier.emailFung, WK: wingfung@hku.hken_US
dc.identifier.authorityFung, WK=rp00696en_US
dc.description.naturepostprint-
dc.identifier.hkuros231278en_US

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