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Conference Paper: Salivary P. gingivalis and PISF IL-1β in periodontally susceptible/non-susceptible individuals

TitleSalivary P. gingivalis and PISF IL-1β in periodontally susceptible/non-susceptible individuals
Authors
KeywordsImplantology
Periodontal organisms and Saliva
Issue Date2014
PublisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
The 92nd General Session & Exhibition of the International Association for Dental Research (IADR), Cape Town, South Africa, 25-28 June 2014. In Journal of Dental Research, 2014, v. 93 n. Special issue B: abstract no. 382 How to Cite?
AbstractObjective: Salivary periodontal pathogens have been implicated as risk indicators for periodontal and peri-implant disease progression. This study aimed to evaluate the salivary level of P. gingivalis as a possible indicator of the proinflammatory response at periimplant mucositis affected sites in periodontally susceptible and non-susceptible cohorts. Method: 53 non-smoker subjects with peri-implant mucositis were evaluated. 26 subjects had a past history of periodontal disease (P-Group) and 27 were periodontally healthy (N-Group). One site with peri-implant mucositis and one with gingivitis was randomly selected for sampling. Sub-marginal/gingival plaque biofilm, peri-implant sulcular fluid (PISF) and whole saliva samples were collected. Real time PCR was used to quantify P. gingivalis in the saliva and plaque samples. Interleukin 1-beta (IL-1β) levels in PISF were determined using ELISA. Subjects were categorized as 'high' (5 log or more) and 'low'(less than 5 log) salivary P.gingivalis carriers and scored according to quartiles of PISF IL-1β levels. Both groups were analyzed for effects of salivary P.gingivaliscarriage on PISF IL-1β score. Result: Salivary P.gingivalis levels were significantly correlated with the plaque levels at peri-implant and gingival niches (p<0.001). N-Group subjects with ‘high’ salivary P. gingivalis had significantly higher PISF IL-1β level than the ‘low’ carriers (p=0.035), whereas no significant difference was found in the P-Group (p=0.552). Conclusion: This preliminary study suggests salivary P. gingivalis is indicative of its biofilm burden at peri-implant and gingival niches. Among non-periodontally susceptible subjects, high salivary P.gingivalis level seemed to be associated with a greater proinflammatory response in peri-implant mucositis, unlike in periodontally susceptible subjects. Host-susceptibility factors seem to modulate the biomarker/risk indicator value of salivary periodontopathogens. Salivary periodontopathogen and PISF IL-1β tests together may be useful for risk assessment in clinical implant dentistry.
DescriptionPoster Presentation
Session 75: Salivary Diagnostics: Oral and Systemic Diseases
Persistent Identifierhttp://hdl.handle.net/10722/199326
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorAcharya, Aen_US
dc.contributor.authorMattheos, Nen_US
dc.contributor.authorWatt, RMen_US
dc.contributor.authorKheur, Sen_US
dc.contributor.authorGopalakrishnan, Den_US
dc.contributor.authorJin, Len_US
dc.date.accessioned2014-07-22T01:13:39Z-
dc.date.available2014-07-22T01:13:39Z-
dc.date.issued2014en_US
dc.identifier.citationThe 92nd General Session & Exhibition of the International Association for Dental Research (IADR), Cape Town, South Africa, 25-28 June 2014. In Journal of Dental Research, 2014, v. 93 n. Special issue B: abstract no. 382en_US
dc.identifier.issn0022-0345en_US
dc.identifier.urihttp://hdl.handle.net/10722/199326-
dc.descriptionPoster Presentation-
dc.descriptionSession 75: Salivary Diagnostics: Oral and Systemic Diseases-
dc.description.abstractObjective: Salivary periodontal pathogens have been implicated as risk indicators for periodontal and peri-implant disease progression. This study aimed to evaluate the salivary level of P. gingivalis as a possible indicator of the proinflammatory response at periimplant mucositis affected sites in periodontally susceptible and non-susceptible cohorts. Method: 53 non-smoker subjects with peri-implant mucositis were evaluated. 26 subjects had a past history of periodontal disease (P-Group) and 27 were periodontally healthy (N-Group). One site with peri-implant mucositis and one with gingivitis was randomly selected for sampling. Sub-marginal/gingival plaque biofilm, peri-implant sulcular fluid (PISF) and whole saliva samples were collected. Real time PCR was used to quantify P. gingivalis in the saliva and plaque samples. Interleukin 1-beta (IL-1β) levels in PISF were determined using ELISA. Subjects were categorized as 'high' (5 log or more) and 'low'(less than 5 log) salivary P.gingivalis carriers and scored according to quartiles of PISF IL-1β levels. Both groups were analyzed for effects of salivary P.gingivaliscarriage on PISF IL-1β score. Result: Salivary P.gingivalis levels were significantly correlated with the plaque levels at peri-implant and gingival niches (p<0.001). N-Group subjects with ‘high’ salivary P. gingivalis had significantly higher PISF IL-1β level than the ‘low’ carriers (p=0.035), whereas no significant difference was found in the P-Group (p=0.552). Conclusion: This preliminary study suggests salivary P. gingivalis is indicative of its biofilm burden at peri-implant and gingival niches. Among non-periodontally susceptible subjects, high salivary P.gingivalis level seemed to be associated with a greater proinflammatory response in peri-implant mucositis, unlike in periodontally susceptible subjects. Host-susceptibility factors seem to modulate the biomarker/risk indicator value of salivary periodontopathogens. Salivary periodontopathogen and PISF IL-1β tests together may be useful for risk assessment in clinical implant dentistry.-
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_US
dc.relation.ispartofJournal of Dental Researchen_US
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc.en_US
dc.subjectImplantology-
dc.subjectPeriodontal organisms and Saliva-
dc.titleSalivary P. gingivalis and PISF IL-1β in periodontally susceptible/non-susceptible individualsen_US
dc.typeConference_Paperen_US
dc.identifier.emailMattheos, N: mattheos@hku.hken_US
dc.identifier.emailWatt, RM: rmwatt@hku.hken_US
dc.identifier.emailJin, L: ljjin@hkucc.hku.hken_US
dc.identifier.authorityMattheos, N=rp01662en_US
dc.identifier.authorityWatt, RM=rp00043en_US
dc.identifier.authorityJin, L=rp00028en_US
dc.identifier.hkuros231060en_US
dc.identifier.volume93en_US
dc.identifier.issueSpecial issue B: abstract no. 382en_US
dc.publisher.placeUnited Statesen_US

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