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Article: Lifestyle modifications in the development of diabetes mellitus and metabolic syndrome in Chinese women who had gestational diabetes mellitus: a randomized interventional trial

TitleLifestyle modifications in the development of diabetes mellitus and metabolic syndrome in Chinese women who had gestational diabetes mellitus: a randomized interventional trial
Authors
Issue Date2014
Citation
Archives of Gynecology and Obstetrics , 2014, v. 289, p. 319-327 How to Cite?
AbstractObjectives: To study whether lifestyle intervention can reduce the development of type II diabetes mellitus (DM) and metabolic syndrome (MS) among Chinese women who had gestational diabetes mellitus (GDM). Methods: A prospective randomized controlled interventional trial of 450 women who had GDM and impaired glucose tolerance (IGT) postpartum. Advice on diet and exercise was given to the intervention group and reinforced in each follow-up visit. Women in both arms were followed for 36 months. Blood pressure and anthropometry were measured at each visit and blood tests were repeated. Results:Fewer women in the intervention group developed DM (15 versus 19 %) but this was not statistically significant, and there was a lower incidence of DM among women over 40 years old. No difference was found in fasting glucose, insulin and homeostasis model assessment (HOMA) index. Both systolic and diastolic blood pressures, and triglyceride level, were lower but the significance was inconsistent among visits. BMI and percentage body fat were also significantly lower in the later visits. There was no difference in waist-hip ratio and basal metabolic rate. Conclusions: Our results demonstrate a trend towards lower incidence of type II DM within 3 years postpartum in GDM women given lifestyle advice, which also potentially offers protection against development of MS, in terms of lower blood pressure and triglyceride level. Women over 40 years old are more likely to benefit. Future studies should address ways to maximize compliance to lifestyle intervention as its potential benefits can be undermined by challenges of motherhood.
Persistent Identifierhttp://hdl.handle.net/10722/199297

 

DC FieldValueLanguage
dc.contributor.authorShek, NWMen_US
dc.contributor.authorNgai, CSWen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorChan, YCen_US
dc.contributor.authorLao, TTHen_US
dc.date.accessioned2014-07-22T01:11:53Z-
dc.date.available2014-07-22T01:11:53Z-
dc.date.issued2014en_US
dc.identifier.citationArchives of Gynecology and Obstetrics , 2014, v. 289, p. 319-327en_US
dc.identifier.urihttp://hdl.handle.net/10722/199297-
dc.description.abstractObjectives: To study whether lifestyle intervention can reduce the development of type II diabetes mellitus (DM) and metabolic syndrome (MS) among Chinese women who had gestational diabetes mellitus (GDM). Methods: A prospective randomized controlled interventional trial of 450 women who had GDM and impaired glucose tolerance (IGT) postpartum. Advice on diet and exercise was given to the intervention group and reinforced in each follow-up visit. Women in both arms were followed for 36 months. Blood pressure and anthropometry were measured at each visit and blood tests were repeated. Results:Fewer women in the intervention group developed DM (15 versus 19 %) but this was not statistically significant, and there was a lower incidence of DM among women over 40 years old. No difference was found in fasting glucose, insulin and homeostasis model assessment (HOMA) index. Both systolic and diastolic blood pressures, and triglyceride level, were lower but the significance was inconsistent among visits. BMI and percentage body fat were also significantly lower in the later visits. There was no difference in waist-hip ratio and basal metabolic rate. Conclusions: Our results demonstrate a trend towards lower incidence of type II DM within 3 years postpartum in GDM women given lifestyle advice, which also potentially offers protection against development of MS, in terms of lower blood pressure and triglyceride level. Women over 40 years old are more likely to benefit. Future studies should address ways to maximize compliance to lifestyle intervention as its potential benefits can be undermined by challenges of motherhood.en_US
dc.languageengen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.titleLifestyle modifications in the development of diabetes mellitus and metabolic syndrome in Chinese women who had gestational diabetes mellitus: a randomized interventional trialen_US
dc.typeArticleen_US
dc.identifier.emailShek, NWM: sheknoel@hku.hken_US
dc.identifier.emailNgai, CSW: cora@hkucc.hku.hken_US
dc.identifier.emailLee, CP: chinpeng@hkucc.hku.hken_US
dc.identifier.emailChan, YC: chanyc4@hkucc.hku.hken_US
dc.identifier.authorityLee, CP=rp01862en_US
dc.identifier.hkuros231910en_US
dc.identifier.volume289en_US
dc.identifier.spage319en_US
dc.identifier.epage327en_US

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