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Article: Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation

TitleImaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation
Authors
Issue Date2014
Citation
Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34 n. 9, p. 1483-1492 How to Cite?
AbstractNegative functional magnetic resonance imaging (fMRI) response in the striatum has been observed in several studies during peripheral sensory stimulation, but its relationship between local field potential (LFP) remains to be elucidated. We performed cerebral blood volume (CBV) fMRI and LFP recordings in normal rats during graded noxious forepaw stimulation at nine stimulus pulse widths. Albeit high LFP–CBV correlation was found in the ipsilateral and contralateral sensory cortices (r=0.89 and 0.95, respectively), the striatal CBV responses were neither positively, nor negatively correlated with LFP (r=0.04), demonstrating that the negative striatal CBV response is not originated from net regional inhibition. To further identify whether this negative CBV response can serve as a marker for striatal functional recovery, two groups of rats (n=5 each) underwent 20- and 45-minute middle cerebral artery occlusion (MCAO) were studied. No CBV response was found in the ipsilateral striatum in both groups immediately after stroke. Improved striatal CBV response was observed on day 28 in the 20-minute MCAO group compared with the 45-minute MCAO group (P<0.05). This study shows that fMRI signals could differ significantly from LFP and that the observed negative CBV response has potential to serve as a marker for striatal functional integrity in rats.
Persistent Identifierhttp://hdl.handle.net/10722/199058
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShih, YYen_US
dc.contributor.authorHuang, Sen_US
dc.contributor.authorChen, YYen_US
dc.contributor.authorLai, HYen_US
dc.contributor.authorKao, YCen_US
dc.contributor.authorDu, Fen_US
dc.contributor.authorHui, SKen_US
dc.contributor.authorDuong, TQen_US
dc.date.accessioned2014-07-22T01:01:43Z-
dc.date.available2014-07-22T01:01:43Z-
dc.date.issued2014en_US
dc.identifier.citationJournal of Cerebral Blood Flow & Metabolism, 2014, v. 34 n. 9, p. 1483-1492en_US
dc.identifier.urihttp://hdl.handle.net/10722/199058-
dc.description.abstractNegative functional magnetic resonance imaging (fMRI) response in the striatum has been observed in several studies during peripheral sensory stimulation, but its relationship between local field potential (LFP) remains to be elucidated. We performed cerebral blood volume (CBV) fMRI and LFP recordings in normal rats during graded noxious forepaw stimulation at nine stimulus pulse widths. Albeit high LFP–CBV correlation was found in the ipsilateral and contralateral sensory cortices (r=0.89 and 0.95, respectively), the striatal CBV responses were neither positively, nor negatively correlated with LFP (r=0.04), demonstrating that the negative striatal CBV response is not originated from net regional inhibition. To further identify whether this negative CBV response can serve as a marker for striatal functional recovery, two groups of rats (n=5 each) underwent 20- and 45-minute middle cerebral artery occlusion (MCAO) were studied. No CBV response was found in the ipsilateral striatum in both groups immediately after stroke. Improved striatal CBV response was observed on day 28 in the 20-minute MCAO group compared with the 45-minute MCAO group (P<0.05). This study shows that fMRI signals could differ significantly from LFP and that the observed negative CBV response has potential to serve as a marker for striatal functional integrity in rats.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Cerebral Blood Flow & Metabolismen_US
dc.titleImaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulationen_US
dc.typeArticleen_US
dc.identifier.emailHui, SK: edshui@hku.hken_US
dc.identifier.authorityHui, SK=rp01832en_US
dc.identifier.doi10.1038/jcbfm.2014.103en_US
dc.identifier.pmid24917039-
dc.identifier.hkuros231065en_US
dc.identifier.isiWOS:000341342800009-

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