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Article: Negative Electrospray Ionization on Porous Supporting Tips for Mass Spectrometric Analysis: Electrostatic Charging Effect on Detection Sensitivity and its Application to Explosive Detection

TitleNegative Electrospray Ionization on Porous Supporting Tips for Mass Spectrometric Analysis: Electrostatic Charging Effect on Detection Sensitivity and its Application to Explosive Detection
Authors
Issue Date2014
PublisherThe Royal Society of Chemistry.
Citation
Analyst, 2014, v. 139, p. 1482-1491 How to Cite?
AbstractThe simplicity and easy manipulation of a porous substrate-based ESI-MS technique have been widely applied to the direct analysis of different types of samples in positive ion mode. However, the study and application of this technique in negative ion mode are sparse. A key challenge could be due to the ease of electrical discharge on supporting tips upon the application of negative voltage. The aim of this study is to investigate the effect of supporting materials, including polyester, polyethylene and wood, on the detection sensitivity of a porous substrate-based negative ESI-MS technique. By using nitrobenzene derivatives and nitrophenol derivatives as the target analytes, it was found that the hydrophobic materials (i.e., polyethylene and polyester) with a higher tendency to accumulate negative charge could enhance the detection sensitivity towards nitrobenzene derivatives via electron-capture ionization; whereas, compounds with electron affinities lower than the cut-off value (1.13 eV) were not detected. Nitrophenol derivatives with pKa smaller than 9.0 could be detected in the form of deprotonated ions; whereas polar materials (i.e., wood), which might undergo competitive deprotonation with the analytes, could suppress the detection sensitivity. With the investigation of the material effects on the detection sensitivity, the porous substrate-based negative ESI-MS method was developed and applied to the direct detection of two commonly encountered explosives in complex samples.
Persistent Identifierhttp://hdl.handle.net/10722/198995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWONG, YMMen_US
dc.contributor.authorMan, SHen_US
dc.contributor.authorLau, KCen_US
dc.contributor.authorChe, CMen_US
dc.contributor.authorNg, KMen_US
dc.date.accessioned2014-07-22T00:59:53Z-
dc.date.available2014-07-22T00:59:53Z-
dc.date.issued2014en_US
dc.identifier.citationAnalyst, 2014, v. 139, p. 1482-1491en_US
dc.identifier.urihttp://hdl.handle.net/10722/198995-
dc.description.abstractThe simplicity and easy manipulation of a porous substrate-based ESI-MS technique have been widely applied to the direct analysis of different types of samples in positive ion mode. However, the study and application of this technique in negative ion mode are sparse. A key challenge could be due to the ease of electrical discharge on supporting tips upon the application of negative voltage. The aim of this study is to investigate the effect of supporting materials, including polyester, polyethylene and wood, on the detection sensitivity of a porous substrate-based negative ESI-MS technique. By using nitrobenzene derivatives and nitrophenol derivatives as the target analytes, it was found that the hydrophobic materials (i.e., polyethylene and polyester) with a higher tendency to accumulate negative charge could enhance the detection sensitivity towards nitrobenzene derivatives via electron-capture ionization; whereas, compounds with electron affinities lower than the cut-off value (1.13 eV) were not detected. Nitrophenol derivatives with pKa smaller than 9.0 could be detected in the form of deprotonated ions; whereas polar materials (i.e., wood), which might undergo competitive deprotonation with the analytes, could suppress the detection sensitivity. With the investigation of the material effects on the detection sensitivity, the porous substrate-based negative ESI-MS method was developed and applied to the direct detection of two commonly encountered explosives in complex samples.en_US
dc.languageengen_US
dc.publisherThe Royal Society of Chemistry.en_US
dc.relation.ispartofAnalysten_US
dc.titleNegative Electrospray Ionization on Porous Supporting Tips for Mass Spectrometric Analysis: Electrostatic Charging Effect on Detection Sensitivity and its Application to Explosive Detectionen_US
dc.typeArticleen_US
dc.identifier.emailMan, SH: bobbymsh@hku.hken_US
dc.identifier.emailChe, CM: cmche@hku.hken_US
dc.identifier.emailNg, KM: kwanmng@hku.hken_US
dc.identifier.authorityChe, CM=rp00670en_US
dc.identifier.authorityNg, KM=rp00766en_US
dc.identifier.doi10.1039/c3an01657aen_US
dc.identifier.pmid24492411-
dc.identifier.hkuros231283en_US
dc.identifier.volume139en_US
dc.identifier.spage1482en_US
dc.identifier.epage1491en_US
dc.identifier.isiWOS:000331867500028-
dc.publisher.placeCambridge, UKen_US

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