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postgraduate thesis: Morphological and metabolic alternations in adipose tissue of EP4 deficient mice

TitleMorphological and metabolic alternations in adipose tissue of EP4 deficient mice
Authors
Issue Date2014
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Tsoi, L. L. [蔡露茵]. (2014). Morphological and metabolic alternations in adipose tissue of EP4 deficient mice. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204656
AbstractObesity is a rising global health burden. The accumulation of fat in the body is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension and cancer. Currently available anti-obesity medications are not effective and safe to meet the medical need for obesity management. Prostaglandin E receptor subtype 4 (EP4) is involved in the development of adipocytes, but the signaling in adipogenesis and the effect on the regulation of energy homeostasis is not clear to understand. Thus, EP4 receptor and its signaling pathway are interest for research. The purpose of this dissertation is to investigate the morphology and metabolic alteration in mice and to elucidate whether the lack of EP4 by administration of L-161,982, a selective EP4 antagonist, could influence lipid metabolism of the adipocytes in subcutaneous white adipose tissue. Our findings revealed that whether the mice were fed with normal or high-fat diet, EP4 has no significant influence on the adipocyte size in subcutaneous white adipose tissues. The lack of EP4 also showed no significant effect on the basal or stimulated lipolysis of subcutaneous white adipose tissue. However, EP4 deficiency reverses hepatic lipid storage in high-fat fed mice compared to those fed with normal diet. In conclusion, EP4 might be altered lipid metabolism in the liver, which is crucial in the management of obesity. Prospective studies are essential to investigate the effect of EP4 and its signaling pathway on adiposity and lipid metabolism in the liver.
DegreeMaster of Medical Sciences
SubjectProstaglandins E - Receptors
Adipose tissues
Dept/ProgramPharmacology and Pharmacy
Persistent Identifierhttp://hdl.handle.net/10722/198799

 

DC FieldValueLanguage
dc.contributor.authorTsoi, Lo-yan, Luc-
dc.contributor.author蔡露茵-
dc.date.accessioned2014-07-10T04:10:15Z-
dc.date.available2014-07-10T04:10:15Z-
dc.date.issued2014-
dc.identifier.citationTsoi, L. L. [蔡露茵]. (2014). Morphological and metabolic alternations in adipose tissue of EP4 deficient mice. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204656-
dc.identifier.urihttp://hdl.handle.net/10722/198799-
dc.description.abstractObesity is a rising global health burden. The accumulation of fat in the body is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension and cancer. Currently available anti-obesity medications are not effective and safe to meet the medical need for obesity management. Prostaglandin E receptor subtype 4 (EP4) is involved in the development of adipocytes, but the signaling in adipogenesis and the effect on the regulation of energy homeostasis is not clear to understand. Thus, EP4 receptor and its signaling pathway are interest for research. The purpose of this dissertation is to investigate the morphology and metabolic alteration in mice and to elucidate whether the lack of EP4 by administration of L-161,982, a selective EP4 antagonist, could influence lipid metabolism of the adipocytes in subcutaneous white adipose tissue. Our findings revealed that whether the mice were fed with normal or high-fat diet, EP4 has no significant influence on the adipocyte size in subcutaneous white adipose tissues. The lack of EP4 also showed no significant effect on the basal or stimulated lipolysis of subcutaneous white adipose tissue. However, EP4 deficiency reverses hepatic lipid storage in high-fat fed mice compared to those fed with normal diet. In conclusion, EP4 might be altered lipid metabolism in the liver, which is crucial in the management of obesity. Prospective studies are essential to investigate the effect of EP4 and its signaling pathway on adiposity and lipid metabolism in the liver.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.lcshProstaglandins E - Receptors-
dc.subject.lcshAdipose tissues-
dc.titleMorphological and metabolic alternations in adipose tissue of EP4 deficient mice-
dc.typePG_Thesis-
dc.identifier.hkulb5204656-
dc.description.thesisnameMaster of Medical Sciences-
dc.description.thesislevelMaster-
dc.description.thesisdisciplinePharmacology and Pharmacy-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5353/th_b5204656-

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