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Conference Paper: Does spontaneous tumor rupture always has an adverse prognostic impact on patients with resectable hepatocellular carcinoma?

TitleDoes spontaneous tumor rupture always has an adverse prognostic impact on patients with resectable hepatocellular carcinoma?
Authors
Issue Date2014
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-HPB.html
Citation
The 11th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA), Seoul, Korea, 22-27 March 2014. In HPB, 2014, v. 16 n. Suppl. 2, p. 108, abstract no. BO14-02 How to Cite?
AbstractIntroduction: Spontaneous tumor rupture (STR) is a life-threatening complication of hepatocellular carcinoma (HCC) with high mortality. Previous study showed that 20% patients with STR could eventually receive hepatectomy after initial haemostasis and attain long-term survival. Nonetheless, the prognostic impact of STR on the prognosis of these patients in relation to non-ruptured resectable HCC is still not known. Method: From 1989 to 2010, a total of 1338 patients received hepatectomy and 84 patients had STR before resection (Group I). Their clinicopatholgical data and survival outcomes were compared with patients who had resections of non-ruptured HCC (Group II). p ≤ 0.05 was regarded as significant. Results: There was no significant difference in preoperative liver function and ICG value. Group I had significantly larger tumor size (10 cm vs. 5.5 cm), higher incidence of multiple tumors (38.1% vs. 27.3%) and microvascular invasion (61.9% vs. 46.5%). The incidence of major vascular invasion was not significantly different between both groups (10.7% vs. 8.1%). When Group I was stratified according to 7th AJCC/TNM classification, after excluding STR as an element from staging, the 3- and 5-year disease-free survival (DFS) rates for T1 were 41.8% and 31.4% in Group I; 61.9% and 51.2% in Group II (p = 0.023); for T2 were 15.4% and 7.7% in Group I, and 32.0% and 24.8% in Group II(p = 0.007); for T3 were 14.7% and 9.8% in Group I, and 16.6% and 13.8% in Group II (P = 0.626). Furthermore, the DFS in Group I were significantly worsened than Group II when tumor size 5-10 cm (5-year DFS: 6.3% vs. 29.3%, P = 0.053) but not when tumor size ≤5 cm (5-year DFS: 31.3% vs. 41.2%, p = 0.224) or >10 cm (5-year DFS 10.4% vs. 15.4%, p = 0.259). Conclusions: STR only has an adverse prognostic impact on early staged or medium-sized tumors. Redefining the significance of STR in future AJCC/TNM staging is indicated.
DescriptionConference theme: New Horizons over Asia
Session: Best Oral 14
Persistent Identifierhttp://hdl.handle.net/10722/198642
ISSN
2015 Impact Factor: 2.918
2015 SCImago Journal Rankings: 1.586

 

DC FieldValueLanguage
dc.contributor.authorChan, ACYen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorCheung, TTen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorDai, WCen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorFan, ST-
dc.contributor.authorLo, CM-
dc.date.accessioned2014-07-07T08:29:34Z-
dc.date.available2014-07-07T08:29:34Z-
dc.date.issued2014en_US
dc.identifier.citationThe 11th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA), Seoul, Korea, 22-27 March 2014. In HPB, 2014, v. 16 n. Suppl. 2, p. 108, abstract no. BO14-02en_US
dc.identifier.issn1365-182X-
dc.identifier.urihttp://hdl.handle.net/10722/198642-
dc.descriptionConference theme: New Horizons over Asia-
dc.descriptionSession: Best Oral 14-
dc.description.abstractIntroduction: Spontaneous tumor rupture (STR) is a life-threatening complication of hepatocellular carcinoma (HCC) with high mortality. Previous study showed that 20% patients with STR could eventually receive hepatectomy after initial haemostasis and attain long-term survival. Nonetheless, the prognostic impact of STR on the prognosis of these patients in relation to non-ruptured resectable HCC is still not known. Method: From 1989 to 2010, a total of 1338 patients received hepatectomy and 84 patients had STR before resection (Group I). Their clinicopatholgical data and survival outcomes were compared with patients who had resections of non-ruptured HCC (Group II). p ≤ 0.05 was regarded as significant. Results: There was no significant difference in preoperative liver function and ICG value. Group I had significantly larger tumor size (10 cm vs. 5.5 cm), higher incidence of multiple tumors (38.1% vs. 27.3%) and microvascular invasion (61.9% vs. 46.5%). The incidence of major vascular invasion was not significantly different between both groups (10.7% vs. 8.1%). When Group I was stratified according to 7th AJCC/TNM classification, after excluding STR as an element from staging, the 3- and 5-year disease-free survival (DFS) rates for T1 were 41.8% and 31.4% in Group I; 61.9% and 51.2% in Group II (p = 0.023); for T2 were 15.4% and 7.7% in Group I, and 32.0% and 24.8% in Group II(p = 0.007); for T3 were 14.7% and 9.8% in Group I, and 16.6% and 13.8% in Group II (P = 0.626). Furthermore, the DFS in Group I were significantly worsened than Group II when tumor size 5-10 cm (5-year DFS: 6.3% vs. 29.3%, P = 0.053) but not when tumor size ≤5 cm (5-year DFS: 31.3% vs. 41.2%, p = 0.224) or >10 cm (5-year DFS 10.4% vs. 15.4%, p = 0.259). Conclusions: STR only has an adverse prognostic impact on early staged or medium-sized tumors. Redefining the significance of STR in future AJCC/TNM staging is indicated.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-HPB.html-
dc.relation.ispartofHPBen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.titleDoes spontaneous tumor rupture always has an adverse prognostic impact on patients with resectable hepatocellular carcinoma?en_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, ACY: acchan@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hku.hken_US
dc.identifier.emailCheung, TT: cheung68@hku.hken_US
dc.identifier.emailChok, KSH: chok6275@hku.hken_US
dc.identifier.emailDai, WC: daiwc@hku.hken_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, ACY=rp00310en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/hpb.12228-
dc.identifier.hkuros229863en_US
dc.identifier.volume16-
dc.identifier.issueSuppl. 2-
dc.identifier.spage108, abstract no. BO14-
dc.identifier.epage02-
dc.publisher.placeUnited Kingdom-

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