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Conference Paper: Does spontaneous tumor rupture always has an adverse prognostic impact on patients with resectable hepatocellular carcinoma?
Title | Does spontaneous tumor rupture always has an adverse prognostic impact on patients with resectable hepatocellular carcinoma? |
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Authors | |
Issue Date | 2014 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-HPB.html |
Citation | The 11th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA), Seoul, Korea, 22-27 March 2014. In HPB, 2014, v. 16 suppl. 2, p. 108, abstract no. BO14-02 How to Cite? |
Abstract | Introduction: Spontaneous tumor rupture (STR) is a
life-threatening complication of hepatocellular carcinoma
(HCC) with high mortality. Previous study
showed that 20% patients with STR could eventually
receive hepatectomy after initial haemostasis and attain
long-term survival. Nonetheless, the prognostic impact
of STR on the prognosis of these patients in relation to
non-ruptured resectable HCC is still not known.
Method: From 1989 to 2010, a total of 1338 patients
received hepatectomy and 84 patients had STR before
resection (Group I). Their clinicopatholgical data and
survival outcomes were compared with patients who
had resections of non-ruptured HCC (Group II).
p ≤ 0.05 was regarded as significant.
Results: There was no significant difference in preoperative
liver function and ICG value. Group I had significantly
larger tumor size (10 cm vs. 5.5 cm), higher
incidence of multiple tumors (38.1% vs. 27.3%) and
microvascular invasion (61.9% vs. 46.5%). The incidence
of major vascular invasion was not significantly
different between both groups (10.7% vs. 8.1%). When
Group I was stratified according to 7th AJCC/TNM
classification, after excluding STR as an element from
staging, the 3- and 5-year disease-free survival (DFS)
rates for T1 were 41.8% and 31.4% in Group I; 61.9%
and 51.2% in Group II (p = 0.023); for T2 were 15.4%
and 7.7% in Group I, and 32.0% and 24.8% in Group
II(p = 0.007); for T3 were 14.7% and 9.8% in Group I,
and 16.6% and 13.8% in Group II (P = 0.626). Furthermore,
the DFS in Group I were significantly worsened
than Group II when tumor size 5-10 cm (5-year
DFS: 6.3% vs. 29.3%, P = 0.053) but not when tumor
size ≤5 cm (5-year DFS: 31.3% vs. 41.2%, p = 0.224)
or >10 cm (5-year DFS 10.4% vs. 15.4%, p = 0.259).
Conclusions: STR only has an adverse prognostic
impact on early staged or medium-sized tumors. Redefining
the significance of STR in future AJCC/TNM
staging is indicated. |
Description | Conference theme: New Horizons over Asia Session: Best Oral 14 |
Persistent Identifier | http://hdl.handle.net/10722/198642 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.141 |
DC Field | Value | Language |
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dc.contributor.author | Chan, ACY | en_US |
dc.contributor.author | Poon, RTP | en_US |
dc.contributor.author | Cheung, TT | en_US |
dc.contributor.author | Chok, KSH | en_US |
dc.contributor.author | Dai, WC | en_US |
dc.contributor.author | Chan, SC | en_US |
dc.contributor.author | Fan, ST | - |
dc.contributor.author | Lo, CM | - |
dc.date.accessioned | 2014-07-07T08:29:34Z | - |
dc.date.available | 2014-07-07T08:29:34Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | The 11th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA), Seoul, Korea, 22-27 March 2014. In HPB, 2014, v. 16 suppl. 2, p. 108, abstract no. BO14-02 | en_US |
dc.identifier.issn | 1365-182X | - |
dc.identifier.uri | http://hdl.handle.net/10722/198642 | - |
dc.description | Conference theme: New Horizons over Asia | - |
dc.description | Session: Best Oral 14 | - |
dc.description.abstract | Introduction: Spontaneous tumor rupture (STR) is a life-threatening complication of hepatocellular carcinoma (HCC) with high mortality. Previous study showed that 20% patients with STR could eventually receive hepatectomy after initial haemostasis and attain long-term survival. Nonetheless, the prognostic impact of STR on the prognosis of these patients in relation to non-ruptured resectable HCC is still not known. Method: From 1989 to 2010, a total of 1338 patients received hepatectomy and 84 patients had STR before resection (Group I). Their clinicopatholgical data and survival outcomes were compared with patients who had resections of non-ruptured HCC (Group II). p ≤ 0.05 was regarded as significant. Results: There was no significant difference in preoperative liver function and ICG value. Group I had significantly larger tumor size (10 cm vs. 5.5 cm), higher incidence of multiple tumors (38.1% vs. 27.3%) and microvascular invasion (61.9% vs. 46.5%). The incidence of major vascular invasion was not significantly different between both groups (10.7% vs. 8.1%). When Group I was stratified according to 7th AJCC/TNM classification, after excluding STR as an element from staging, the 3- and 5-year disease-free survival (DFS) rates for T1 were 41.8% and 31.4% in Group I; 61.9% and 51.2% in Group II (p = 0.023); for T2 were 15.4% and 7.7% in Group I, and 32.0% and 24.8% in Group II(p = 0.007); for T3 were 14.7% and 9.8% in Group I, and 16.6% and 13.8% in Group II (P = 0.626). Furthermore, the DFS in Group I were significantly worsened than Group II when tumor size 5-10 cm (5-year DFS: 6.3% vs. 29.3%, P = 0.053) but not when tumor size ≤5 cm (5-year DFS: 31.3% vs. 41.2%, p = 0.224) or >10 cm (5-year DFS 10.4% vs. 15.4%, p = 0.259). Conclusions: STR only has an adverse prognostic impact on early staged or medium-sized tumors. Redefining the significance of STR in future AJCC/TNM staging is indicated. | - |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-HPB.html | - |
dc.relation.ispartof | HPB | en_US |
dc.rights | The definitive version is available at www3.interscience.wiley.com | - |
dc.title | Does spontaneous tumor rupture always has an adverse prognostic impact on patients with resectable hepatocellular carcinoma? | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Chan, ACY: acchan@hku.hk | en_US |
dc.identifier.email | Poon, RTP: poontp@hku.hk | en_US |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | en_US |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | en_US |
dc.identifier.email | Dai, WC: daiwc@hku.hk | en_US |
dc.identifier.email | Chan, SC: chanlsc@hkucc.hku.hk | en_US |
dc.identifier.email | Fan, ST: stfan@hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
dc.identifier.authority | Chan, ACY=rp00310 | en_US |
dc.identifier.authority | Poon, RTP=rp00446 | en_US |
dc.identifier.authority | Chan, SC=rp01568 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/hpb.12228 | - |
dc.identifier.hkuros | 229863 | en_US |
dc.identifier.volume | 16 | - |
dc.identifier.issue | suppl. 2 | - |
dc.identifier.spage | 108, abstract no. BO14-02 | - |
dc.identifier.epage | 108, abstract no. BO14-02 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1365-182X | - |