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Article: Differential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinoma

TitleDifferential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinoma
Authors
Issue Date2014
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
Biomed Research International, 2014, v. 2014, article no. 404567 How to Cite?
AbstractBackground. Recent studies suggested that non-protein-coding genes are implicated in the tumorigenic process of nasopharyngeal carcinoma (NPC). In the present study, we aimed to identify the differentially expressed long noncoding RNA (lncRNA) using data available in the public domain. Methods. Microarray data set GSE12452 was reannotated with ncFANs. Real-time quantitative PCR was used to quantify and validate the identified lncRNAs in NPC. Results. In primary NPC, upregulation of lnc-C22orf32-1, lnc-AL355149.1-1, and lnc-ZNF674-1 was observed. High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients. In addition, increased expression of lnc-C22orf32-1 and lnc-ZNF674-1 was associated with advanced tumor stages. Recurrent NPC displayed a distinctive lncRNA expression pattern. lnc-BCL2L11-3 was significantly increased in the recurrent NPC tissues. In addition, significant reduction of lnc-AL355149.1-1 and lnc-ZNF674-1 was observed in the recurrent NPC tissues. Conclusions. Our results demonstrated that it is feasible to identify the differentially expressed lncRNA in the microarray dataset by functional reannotation. The association of lncRNA with gender and tumor size implicated that lncRNA possibly plays a part in the pathogenesis of primary NPC. Further, the distinctive lncRNA identified in the recurrent NPC may reveal a distinctive development mechanism underlying tumor recurrence. © 2014 Wei Gao et al.
Persistent Identifierhttp://hdl.handle.net/10722/198575
ISSN
2015 Impact Factor: 2.134
2015 SCImago Journal Rankings: 0.725
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Wen_US
dc.contributor.authorChan, JYWen_US
dc.contributor.authorWong, TSen_US
dc.date.accessioned2014-07-07T07:57:38Z-
dc.date.available2014-07-07T07:57:38Z-
dc.date.issued2014en_US
dc.identifier.citationBiomed Research International, 2014, v. 2014, article no. 404567en_US
dc.identifier.issn2314-6133-
dc.identifier.urihttp://hdl.handle.net/10722/198575-
dc.description.abstractBackground. Recent studies suggested that non-protein-coding genes are implicated in the tumorigenic process of nasopharyngeal carcinoma (NPC). In the present study, we aimed to identify the differentially expressed long noncoding RNA (lncRNA) using data available in the public domain. Methods. Microarray data set GSE12452 was reannotated with ncFANs. Real-time quantitative PCR was used to quantify and validate the identified lncRNAs in NPC. Results. In primary NPC, upregulation of lnc-C22orf32-1, lnc-AL355149.1-1, and lnc-ZNF674-1 was observed. High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients. In addition, increased expression of lnc-C22orf32-1 and lnc-ZNF674-1 was associated with advanced tumor stages. Recurrent NPC displayed a distinctive lncRNA expression pattern. lnc-BCL2L11-3 was significantly increased in the recurrent NPC tissues. In addition, significant reduction of lnc-AL355149.1-1 and lnc-ZNF674-1 was observed in the recurrent NPC tissues. Conclusions. Our results demonstrated that it is feasible to identify the differentially expressed lncRNA in the microarray dataset by functional reannotation. The association of lncRNA with gender and tumor size implicated that lncRNA possibly plays a part in the pathogenesis of primary NPC. Further, the distinctive lncRNA identified in the recurrent NPC may reveal a distinctive development mechanism underlying tumor recurrence. © 2014 Wei Gao et al.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html-
dc.relation.ispartofBiomed Research Internationalen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDifferential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailGao, W: weigao@graduate.hku.hken_US
dc.identifier.emailChan, YW: jywchan1@hku.hken_US
dc.identifier.emailWong, TS: thiansze@graduate.hku.hken_US
dc.identifier.authorityChan, YW=rp01314en_US
dc.identifier.authorityWong, TS=rp00478en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2014/404567-
dc.identifier.pmid24822202-
dc.identifier.pmcidPMC4009106-
dc.identifier.scopuseid_2-s2.0-84899999295-
dc.identifier.hkuros229897en_US
dc.identifier.hkuros229171-
dc.identifier.volume2014en_US
dc.identifier.isiWOS:000335167500001-

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