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Article: Concise review: the surface markers and identity of human mesenchymal stem cells

TitleConcise review: the surface markers and identity of human mesenchymal stem cells
Authors
Issue Date2014
Citation
Stem Cells, 2014, v. 6, p. 1408-19 How to Cite?
AbstractThe concept of mesenchymal stem cells (MSCs) is becoming increasingly obscure due to the recent findings of heterogeneous populations with different levels of stemness within MSCs isolated by traditional plastic adherence. MSCs were originally identified in bone marrow and later detected in many other tissues. Currently, no cloning based on single surface marker is capable of isolating cells that satisfy the minimal criteria of MSCs from various tissue environments. Markers that associate with the stemness of MSCs await to be elucidated. A number of candidate MSC surface markers or markers possibly related to their stemness have been brought forward so far, including Stro-1, SSEA-4, CD271, and CD146, yet there is a large difference in their expression in various sources of MSCs. The exact identity of MSCs in vivo is not yet clear, although reports have suggested they may have a fibroblastic or pericytic origin. In this review, we revisit the reported expression of surface molecules in MSCs from various sources, aiming to assess their potential as MSC markers and define the critical panel for future investigation. We also discuss the relationship of MSCs to fibroblasts and pericytes in an attempt to shed light on their identity in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/198550

 

DC FieldValueLanguage
dc.contributor.authorLv, Fen_US
dc.contributor.authorTuan, RSen_US
dc.contributor.authorCheung, KMCen_US
dc.contributor.authorLeung, VYLen_US
dc.date.accessioned2014-07-07T07:31:36Z-
dc.date.available2014-07-07T07:31:36Z-
dc.date.issued2014en_US
dc.identifier.citationStem Cells, 2014, v. 6, p. 1408-19en_US
dc.identifier.urihttp://hdl.handle.net/10722/198550-
dc.description.abstractThe concept of mesenchymal stem cells (MSCs) is becoming increasingly obscure due to the recent findings of heterogeneous populations with different levels of stemness within MSCs isolated by traditional plastic adherence. MSCs were originally identified in bone marrow and later detected in many other tissues. Currently, no cloning based on single surface marker is capable of isolating cells that satisfy the minimal criteria of MSCs from various tissue environments. Markers that associate with the stemness of MSCs await to be elucidated. A number of candidate MSC surface markers or markers possibly related to their stemness have been brought forward so far, including Stro-1, SSEA-4, CD271, and CD146, yet there is a large difference in their expression in various sources of MSCs. The exact identity of MSCs in vivo is not yet clear, although reports have suggested they may have a fibroblastic or pericytic origin. In this review, we revisit the reported expression of surface molecules in MSCs from various sources, aiming to assess their potential as MSC markers and define the critical panel for future investigation. We also discuss the relationship of MSCs to fibroblasts and pericytes in an attempt to shed light on their identity in vivo.en_US
dc.languageengen_US
dc.relation.ispartofStem Cellsen_US
dc.titleConcise review: the surface markers and identity of human mesenchymal stem cellsen_US
dc.typeArticleen_US
dc.identifier.emailLv, F: fengjuan@hku.hken_US
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_US
dc.identifier.emailLeung, VYL: vicleung@hku.hken_US
dc.identifier.authorityCheung, KMC=rp00387en_US
dc.identifier.authorityLeung, VYL=rp01764en_US
dc.identifier.hkuros230046en_US
dc.identifier.volume6en_US
dc.identifier.spage1408en_US
dc.identifier.epage19en_US

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