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Article: Differing epidemiological dynamics of influenza B virus lineages in Guangzhou, southern China, 2009-2010

TitleDiffering epidemiological dynamics of influenza B virus lineages in Guangzhou, southern China, 2009-2010
Authors
Issue Date2013
Citation
Journal of Virology, 2013, v. 87, p. 12447-12456 How to Cite?
AbstractThe epidemiological and evolutionary dynamics of the two cocirculating lineages of influenza B virus, Victoria and Yamagata, are poorly understood, especially in tropical or subtropical areas of Southeast Asia. We performed a phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza B viruses isolated in Guangzhou, a southern Chinese city, during 2009 to 2010 and compared the demographic and clinical features of infected patients. We identified multiple viral introductions of Victoria strains from both Chinese and international sources, which formed two phylogenetically and antigenically distinct clades (Victoria 1 and 2), some of which persisted between seasons. We identified one dominant Yamagata introduction from outside China during 2009. Our phylogenetic analysis reveals the occurrence of reassortment events among the Victoria and Yamagata lineages and also within the Victoria lineage. We found no significant difference in clinical severity by influenza B lineage, with the exceptions that (i) the Yamagata lineage infected older people than either Victoria lineage and (ii) fewer upper respiratory tract infections were caused by the Victoria 2 than the Victoria 1 clade. Overall, our study reveals the complex epidemiological dynamics of different influenza B lineages within a single geographic locality and has implications for vaccination policy in southern China.
Persistent Identifierhttp://hdl.handle.net/10722/198352
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTan, Yen_US
dc.contributor.authorGuan, Wen_US
dc.contributor.authorLam, TYen_US
dc.contributor.authorPan, Sen_US
dc.contributor.authorWu, Sen_US
dc.contributor.authorZhan, Yen_US
dc.contributor.authorViboud, Cen_US
dc.contributor.authorHolmes, ECen_US
dc.contributor.authorYang, Zen_US
dc.date.accessioned2014-06-25T03:04:31Z-
dc.date.available2014-06-25T03:04:31Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Virology, 2013, v. 87, p. 12447-12456en_US
dc.identifier.urihttp://hdl.handle.net/10722/198352-
dc.description.abstractThe epidemiological and evolutionary dynamics of the two cocirculating lineages of influenza B virus, Victoria and Yamagata, are poorly understood, especially in tropical or subtropical areas of Southeast Asia. We performed a phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza B viruses isolated in Guangzhou, a southern Chinese city, during 2009 to 2010 and compared the demographic and clinical features of infected patients. We identified multiple viral introductions of Victoria strains from both Chinese and international sources, which formed two phylogenetically and antigenically distinct clades (Victoria 1 and 2), some of which persisted between seasons. We identified one dominant Yamagata introduction from outside China during 2009. Our phylogenetic analysis reveals the occurrence of reassortment events among the Victoria and Yamagata lineages and also within the Victoria lineage. We found no significant difference in clinical severity by influenza B lineage, with the exceptions that (i) the Yamagata lineage infected older people than either Victoria lineage and (ii) fewer upper respiratory tract infections were caused by the Victoria 2 than the Victoria 1 clade. Overall, our study reveals the complex epidemiological dynamics of different influenza B lineages within a single geographic locality and has implications for vaccination policy in southern China.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Virologyen_US
dc.titleDiffering epidemiological dynamics of influenza B virus lineages in Guangzhou, southern China, 2009-2010en_US
dc.typeArticleen_US
dc.identifier.emailLam, TY: ttylam@hku.hken_US
dc.identifier.authorityLam, TY=rp01733en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.01039-13en_US
dc.identifier.pmid24027322-
dc.identifier.hkuros229495en_US
dc.identifier.volume87en_US
dc.identifier.spage12447en_US
dc.identifier.epage12456en_US
dc.identifier.isiWOS:000325865400044-

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