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Article: Prognostic significance of CD26 in patients with colorectal cancer

TitlePrognostic significance of CD26 in patients with colorectal cancer
Authors
Issue Date2014
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2014, v. 9 n. 5, article no. e98582 How to Cite?
AbstractBackground: CD26, dipeptidyl peptidase IV, was discovered firstly as a membrane-associated peptidase on the surface of leukocyte. We previously demonstrated that a subpopulation of CD26+ cells were associated with the development of distant metastasis, enhanced invasiveness and chemoresistance in colorectal cancer (CRC). In order to understand the clinical impact of CD26, the expression was investigated in CRC patient's specimens. This study investigated the prognostic significance of tumour CD26 expression in patients with CRC. Examination of CD26+ cells has significant clinical impact for the prediction of distant metastasis development in colorectal cancer, and could be used as a selection criterion for further therapy. Methods: Tumour CD26 expression levels were studied by immunohistochemistry using Formalin-fixed paraffin embedded (FFPE) tissues in 143 patients with CRC. Tumour CD26 expression levels were correlated with clinicopathological features of the CRC patients. The prognostic significance of tumour tissue CD26 expression levels was assessed by univariate and multivariate analyses. Result: CD26 expression levels in CRC patients with distant metastasis were significantly higher than those in non-metastatic. High expression levels of CD26 were significantly associated with advanced tumour staging. Patients with a high CD26 expression level had significantly worse overall survival than those with a lower level (p<0.001). Conclusions: The expression of CD26 was positively associated with clinicopathological correlation such as TNM staging, degree of differentiation and development of metastasis. A high CD26 expression level is a predictor of poor outcome after resection of CRC. CD26 may be a useful prognostic marker in patients with CRC. © 2014 Lam et al.
Persistent Identifierhttp://hdl.handle.net/10722/198114
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLam, CSCen_US
dc.contributor.authorCheung, AHKen_US
dc.contributor.authorWong, SKMen_US
dc.contributor.authorWan, TMHen_US
dc.contributor.authorNg, Len_US
dc.contributor.authorChow, AKMen_US
dc.contributor.authorCheng, NSMen_US
dc.contributor.authorPak, RCHen_US
dc.contributor.authorLi, HSen_US
dc.contributor.authorMan, JHWen_US
dc.contributor.authorYau, TCCen_US
dc.contributor.authorLo, OSHen_US
dc.contributor.authorPoon, TCJen_US
dc.contributor.authorPang, RWCen_US
dc.contributor.authorLaw, WLen_US
dc.date.accessioned2014-06-25T02:47:32Z-
dc.date.available2014-06-25T02:47:32Z-
dc.date.issued2014en_US
dc.identifier.citationPLoS One, 2014, v. 9 n. 5, article no. e98582en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/198114-
dc.description.abstractBackground: CD26, dipeptidyl peptidase IV, was discovered firstly as a membrane-associated peptidase on the surface of leukocyte. We previously demonstrated that a subpopulation of CD26+ cells were associated with the development of distant metastasis, enhanced invasiveness and chemoresistance in colorectal cancer (CRC). In order to understand the clinical impact of CD26, the expression was investigated in CRC patient's specimens. This study investigated the prognostic significance of tumour CD26 expression in patients with CRC. Examination of CD26+ cells has significant clinical impact for the prediction of distant metastasis development in colorectal cancer, and could be used as a selection criterion for further therapy. Methods: Tumour CD26 expression levels were studied by immunohistochemistry using Formalin-fixed paraffin embedded (FFPE) tissues in 143 patients with CRC. Tumour CD26 expression levels were correlated with clinicopathological features of the CRC patients. The prognostic significance of tumour tissue CD26 expression levels was assessed by univariate and multivariate analyses. Result: CD26 expression levels in CRC patients with distant metastasis were significantly higher than those in non-metastatic. High expression levels of CD26 were significantly associated with advanced tumour staging. Patients with a high CD26 expression level had significantly worse overall survival than those with a lower level (p<0.001). Conclusions: The expression of CD26 was positively associated with clinicopathological correlation such as TNM staging, degree of differentiation and development of metastasis. A high CD26 expression level is a predictor of poor outcome after resection of CRC. CD26 may be a useful prognostic marker in patients with CRC. © 2014 Lam et al.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePrognostic significance of CD26 in patients with colorectal canceren_US
dc.typeArticleen_US
dc.identifier.emailLam, CSC: colin88@hku.hken_US
dc.identifier.emailWan, TMH: tmhwan@hku.hken_US
dc.identifier.emailNg, L: luing@hku.hken_US
dc.identifier.emailChow, AKM: chowakm@hku.hken_US
dc.identifier.emailPak, RCH: zeusod1@hku.hken_US
dc.identifier.emailLi, HS: lhsing@hku.hken_US
dc.identifier.emailYau, TCC: tyaucc@hku.hken_US
dc.identifier.emailLo, OSH: oswens@hku.hken_US
dc.identifier.emailPoon, TCJ: tcjensen@hku.hken_US
dc.identifier.emailPang, RWC: robertap@hku.hken_US
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.authorityYau, TCC=rp01466en_US
dc.identifier.authorityPoon, TCJ=rp01603en_US
dc.identifier.authorityPang, RWC=rp00274en_US
dc.identifier.authorityLaw, WL=rp00436en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0098582-
dc.identifier.pmid24870408-
dc.identifier.pmcidPMC4037185-
dc.identifier.scopuseid_2-s2.0-84901630152-
dc.identifier.hkuros229428en_US
dc.identifier.volume9en_US
dc.identifier.issue5en_US
dc.publisher.placeUnited States-

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