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- Publisher Website: 10.12659/AOT.889995
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- PMID: 24881673
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Article: Human herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipients
Title | Human herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipients |
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Authors | |
Keywords | Children Hematopoietic stem cell transplantation Herpesvirus |
Issue Date | 2014 |
Citation | Annals of Transplantation, 2014, v. 19, p. 269-276 How to Cite? |
Abstract | Background The immunosuppressed state in patients undergoing hematopoietic stem cell transplantation (HSCT) predisposes them to activation of latent viral infections such as herpesvirus types 6 and 7 (HHV6 and HHV7). We aimed to evaluate the incidence, manifestations, outcomes, and risk factors of HHV 6 and HHV 7 infections after pediatric hematopoietic stem cell transplantation. Material and Methods We performed 106 HSCTs (86 allogeneic and 20 autologous) on 94 children (56 boys, median age 7.1 years) during 2006-2012. Patients suspected to have HHV6 or HHV7 infections were tested using polymerase chain reaction on serum and/or cerebrospinal fluid. Results Among the 63 patients tested for HHV, 10 patients (15.9%) were infected (HHV-6 (n=6), HHV-7 (n=4)) at a median of 18 days post-HSCT (cumulative incidence 11.5% at 1 year). Manifestations included fever (90%), rash (70%), hepatitis (80%), pneumonitis (50%), central nervous system (CNS) manifestations (40%), and graft failure (10%). One patient had persistent CNS infection despite treatment with foscarnet, ganciclovir, and cidofovir. Seven patients cleared herpesvirus after a median of 22 days. Four patients died (relapse of malignancy [n=3], acute graft-versus-host disease [aGVHD] [n=1]). Herpesvirus infections were associated with adenovirus infection (p=0.001) and severe (grade III-IV) aGVHD (p=0.037). Conclusions We concluded that HHV6 and HHV7 infections are common after pediatric HSCT. Most infections were self-limited and could be associated with adenovirus infection and severe aGVHD. Further studies are needed to evaluate predictors of severe morbidity or mortality, and define optimal prophylaxis and treatment. |
Persistent Identifier | http://hdl.handle.net/10722/198061 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fule, JDR | en_US |
dc.contributor.author | Cheuk, KLD | en_US |
dc.contributor.author | Ha, SY | en_US |
dc.contributor.author | Chiang, AKS | en_US |
dc.contributor.author | Chan, GCF | en_US |
dc.date.accessioned | 2014-06-25T02:43:48Z | - |
dc.date.available | 2014-06-25T02:43:48Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Annals of Transplantation, 2014, v. 19, p. 269-276 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/198061 | - |
dc.description.abstract | Background The immunosuppressed state in patients undergoing hematopoietic stem cell transplantation (HSCT) predisposes them to activation of latent viral infections such as herpesvirus types 6 and 7 (HHV6 and HHV7). We aimed to evaluate the incidence, manifestations, outcomes, and risk factors of HHV 6 and HHV 7 infections after pediatric hematopoietic stem cell transplantation. Material and Methods We performed 106 HSCTs (86 allogeneic and 20 autologous) on 94 children (56 boys, median age 7.1 years) during 2006-2012. Patients suspected to have HHV6 or HHV7 infections were tested using polymerase chain reaction on serum and/or cerebrospinal fluid. Results Among the 63 patients tested for HHV, 10 patients (15.9%) were infected (HHV-6 (n=6), HHV-7 (n=4)) at a median of 18 days post-HSCT (cumulative incidence 11.5% at 1 year). Manifestations included fever (90%), rash (70%), hepatitis (80%), pneumonitis (50%), central nervous system (CNS) manifestations (40%), and graft failure (10%). One patient had persistent CNS infection despite treatment with foscarnet, ganciclovir, and cidofovir. Seven patients cleared herpesvirus after a median of 22 days. Four patients died (relapse of malignancy [n=3], acute graft-versus-host disease [aGVHD] [n=1]). Herpesvirus infections were associated with adenovirus infection (p=0.001) and severe (grade III-IV) aGVHD (p=0.037). Conclusions We concluded that HHV6 and HHV7 infections are common after pediatric HSCT. Most infections were self-limited and could be associated with adenovirus infection and severe aGVHD. Further studies are needed to evaluate predictors of severe morbidity or mortality, and define optimal prophylaxis and treatment. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Annals of Transplantation | en_US |
dc.subject | Children | - |
dc.subject | Hematopoietic stem cell transplantation | - |
dc.subject | Herpesvirus | - |
dc.title | Human herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipients | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheuk, KLD: klcheuk@hkucc.hku.hk | en_US |
dc.identifier.email | Ha, SY: syha@hku.hk | en_US |
dc.identifier.email | Chiang, AKS: chiangak@hku.hk | en_US |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | en_US |
dc.identifier.authority | Chiang, AKS=rp00403 | en_US |
dc.identifier.authority | Chan, GCF=rp00431 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.12659/AOT.889995 | - |
dc.identifier.pmid | 24881673 | - |
dc.identifier.scopus | eid_2-s2.0-84902120222 | - |
dc.identifier.hkuros | 229247 | en_US |
dc.identifier.spage | 269 | en_US |
dc.identifier.epage | 276 | en_US |
dc.identifier.eissn | 2329-0358 | - |
dc.identifier.isi | WOS:000343062800001 | - |
dc.identifier.issnl | 1425-9524 | - |