File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Human herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipients

TitleHuman herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipients
Authors
Issue Date2014
Citation
Annals of Transplantation, 2014, v. 19, p. 269-276 How to Cite?
AbstractBackground The immunosuppressed state in patients undergoing hematopoietic stem cell transplantation (HSCT) predisposes them to activation of latent viral infections such as herpesvirus types 6 and 7 (HHV6 and HHV7). We aimed to evaluate the incidence, manifestations, outcomes, and risk factors of HHV 6 and HHV 7 infections after pediatric hematopoietic stem cell transplantation. Material and Methods We performed 106 HSCTs (86 allogeneic and 20 autologous) on 94 children (56 boys, median age 7.1 years) during 2006-2012. Patients suspected to have HHV6 or HHV7 infections were tested using polymerase chain reaction on serum and/or cerebrospinal fluid. Results Among the 63 patients tested for HHV, 10 patients (15.9%) were infected (HHV-6 (n=6), HHV-7 (n=4)) at a median of 18 days post-HSCT (cumulative incidence 11.5% at 1 year). Manifestations included fever (90%), rash (70%), hepatitis (80%), pneumonitis (50%), central nervous system (CNS) manifestations (40%), and graft failure (10%). One patient had persistent CNS infection despite treatment with foscarnet, ganciclovir, and cidofovir. Seven patients cleared herpesvirus after a median of 22 days. Four patients died (relapse of malignancy [n=3], acute graft-versus-host disease [aGVHD] [n=1]). Herpesvirus infections were associated with adenovirus infection (p=0.001) and severe (grade III-IV) aGVHD (p=0.037). Conclusions We concluded that HHV6 and HHV7 infections are common after pediatric HSCT. Most infections were self-limited and could be associated with adenovirus infection and severe aGVHD. Further studies are needed to evaluate predictors of severe morbidity or mortality, and define optimal prophylaxis and treatment.
Persistent Identifierhttp://hdl.handle.net/10722/198061

 

DC FieldValueLanguage
dc.contributor.authorFule, JDRen_US
dc.contributor.authorCheuk, KLDen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorChiang, AKSen_US
dc.contributor.authorChan, GCFen_US
dc.date.accessioned2014-06-25T02:43:48Z-
dc.date.available2014-06-25T02:43:48Z-
dc.date.issued2014en_US
dc.identifier.citationAnnals of Transplantation, 2014, v. 19, p. 269-276en_US
dc.identifier.urihttp://hdl.handle.net/10722/198061-
dc.description.abstractBackground The immunosuppressed state in patients undergoing hematopoietic stem cell transplantation (HSCT) predisposes them to activation of latent viral infections such as herpesvirus types 6 and 7 (HHV6 and HHV7). We aimed to evaluate the incidence, manifestations, outcomes, and risk factors of HHV 6 and HHV 7 infections after pediatric hematopoietic stem cell transplantation. Material and Methods We performed 106 HSCTs (86 allogeneic and 20 autologous) on 94 children (56 boys, median age 7.1 years) during 2006-2012. Patients suspected to have HHV6 or HHV7 infections were tested using polymerase chain reaction on serum and/or cerebrospinal fluid. Results Among the 63 patients tested for HHV, 10 patients (15.9%) were infected (HHV-6 (n=6), HHV-7 (n=4)) at a median of 18 days post-HSCT (cumulative incidence 11.5% at 1 year). Manifestations included fever (90%), rash (70%), hepatitis (80%), pneumonitis (50%), central nervous system (CNS) manifestations (40%), and graft failure (10%). One patient had persistent CNS infection despite treatment with foscarnet, ganciclovir, and cidofovir. Seven patients cleared herpesvirus after a median of 22 days. Four patients died (relapse of malignancy [n=3], acute graft-versus-host disease [aGVHD] [n=1]). Herpesvirus infections were associated with adenovirus infection (p=0.001) and severe (grade III-IV) aGVHD (p=0.037). Conclusions We concluded that HHV6 and HHV7 infections are common after pediatric HSCT. Most infections were self-limited and could be associated with adenovirus infection and severe aGVHD. Further studies are needed to evaluate predictors of severe morbidity or mortality, and define optimal prophylaxis and treatment.en_US
dc.languageengen_US
dc.relation.ispartofAnnals of Transplantationen_US
dc.titleHuman herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipientsen_US
dc.typeArticleen_US
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hken_US
dc.identifier.emailHa, SY: syha@hku.hken_US
dc.identifier.emailChiang, AKS: chiangak@hku.hken_US
dc.identifier.emailChan, GCF: gcfchan@hku.hken_US
dc.identifier.authorityChiang, AKS=rp00403en_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.12659/AOT.889995-
dc.identifier.pmid24881673-
dc.identifier.hkuros229247en_US
dc.identifier.spage269en_US
dc.identifier.epage276en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats