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Article: Detection of colorectal adenoma by narrow band imaging (HQ190) vs. high-definition white light colonoscopy: a randomized controlled trial

TitleDetection of colorectal adenoma by narrow band imaging (HQ190) vs. high-definition white light colonoscopy: a randomized controlled trial
Authors
Issue Date2014
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal of Gastroenterology, 2014, v. 109 n. 6, p. 855-863 How to Cite?
AbstractOBJECTIVES: The benefits of narrow band imaging (NBI) on enhancing colorectal adenoma detection remain questionable. We tested whether the new generation of NBI (190-NBI), which is twice as bright as the previous version, would improve adenoma detection when compared with high-definition white light (HD-WL) colonoscopy. METHODS: It was a randomized controlled trial with tandem colonoscopy. We recruited patients who underwent colonoscopy for symptoms, screening, or surveillance. Patients were randomized for the use of either 190-NBI or HD-WL on withdrawal. Tandem colonoscopy was performed by using the same assigned colonoscope and withdrawal method. Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates, respectively. The primary outcomes were adenoma and polyp detection rates. RESULTS: A total of 360 patients were randomized to undergo either 190-NBI or HD-WL colonoscopy. Both the adenoma and polyp detection rates were significantly higher in the 190-NBI group compared with the HD-WL group (adenoma: 48.3% vs. 34.4%, P=0.01; polyps: 61.1% vs. 48.3%, P=0.02). The mean number of polyps detected per patient was higher in the 190-NBI group (1.49% vs. 1.13, P=0.07). There was no significant difference in the adenoma miss rates between the two groups (21.8% vs. 21.2%). Multivariate analysis showed that the use of 190-NBI (odds ratio (OR) 1.85; 95% confidence interval (CI) 1.10-3.12), withdrawal time (OR 1.29; CI 1.19-1.38), patient's age (OR 1.04; CI 1.01-1.06), and male gender (OR 2.38; CI 1.42-3.99) were associated with adenoma detection. CONCLUSIONS: 190-NBI colonoscopy was superior to the conventional HD-WL in detecting colorectal adenomas or polyps, but there was no significant difference in adenoma miss rates.
Persistent Identifierhttp://hdl.handle.net/10722/198048
ISSN
2017 Impact Factor: 10.231
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, WK-
dc.contributor.authorLo, OSH-
dc.contributor.authorLiu, KSH-
dc.contributor.authorTong, T-
dc.contributor.authorBut, DYK-
dc.contributor.authorLam, FYF-
dc.contributor.authorHsu, ASJ-
dc.contributor.authorWong, SY-
dc.contributor.authorSeto, WKW-
dc.contributor.authorHung, IFN-
dc.contributor.authorLaw, WL-
dc.date.accessioned2014-06-25T02:42:10Z-
dc.date.available2014-06-25T02:42:10Z-
dc.date.issued2014-
dc.identifier.citationAmerican Journal of Gastroenterology, 2014, v. 109 n. 6, p. 855-863-
dc.identifier.issn0002-9270-
dc.identifier.urihttp://hdl.handle.net/10722/198048-
dc.description.abstractOBJECTIVES: The benefits of narrow band imaging (NBI) on enhancing colorectal adenoma detection remain questionable. We tested whether the new generation of NBI (190-NBI), which is twice as bright as the previous version, would improve adenoma detection when compared with high-definition white light (HD-WL) colonoscopy. METHODS: It was a randomized controlled trial with tandem colonoscopy. We recruited patients who underwent colonoscopy for symptoms, screening, or surveillance. Patients were randomized for the use of either 190-NBI or HD-WL on withdrawal. Tandem colonoscopy was performed by using the same assigned colonoscope and withdrawal method. Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates, respectively. The primary outcomes were adenoma and polyp detection rates. RESULTS: A total of 360 patients were randomized to undergo either 190-NBI or HD-WL colonoscopy. Both the adenoma and polyp detection rates were significantly higher in the 190-NBI group compared with the HD-WL group (adenoma: 48.3% vs. 34.4%, P=0.01; polyps: 61.1% vs. 48.3%, P=0.02). The mean number of polyps detected per patient was higher in the 190-NBI group (1.49% vs. 1.13, P=0.07). There was no significant difference in the adenoma miss rates between the two groups (21.8% vs. 21.2%). Multivariate analysis showed that the use of 190-NBI (odds ratio (OR) 1.85; 95% confidence interval (CI) 1.10-3.12), withdrawal time (OR 1.29; CI 1.19-1.38), patient's age (OR 1.04; CI 1.01-1.06), and male gender (OR 2.38; CI 1.42-3.99) were associated with adenoma detection. CONCLUSIONS: 190-NBI colonoscopy was superior to the conventional HD-WL in detecting colorectal adenomas or polyps, but there was no significant difference in adenoma miss rates.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html-
dc.relation.ispartofAmerican Journal of Gastroenterology-
dc.titleDetection of colorectal adenoma by narrow band imaging (HQ190) vs. high-definition white light colonoscopy: a randomized controlled trial-
dc.typeArticle-
dc.identifier.emailLeung, WK: hku75407@hku.hk-
dc.identifier.emailLo, OSH: oswens@hku.hk-
dc.identifier.emailBut, DYK: drdbut@hku.hk-
dc.identifier.emailLam, FYF: fyflam@hku.hk-
dc.identifier.emailHsu, ASJ: axelhsu@hku.hk-
dc.identifier.emailWong, SY: ksywong@hkucc.hku.hk-
dc.identifier.emailSeto, WKW: wkseto2@hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.identifier.authorityLam, FYF=rp02564-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityLaw, WL=rp00436-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajg.2014.83-
dc.identifier.pmid24751581-
dc.identifier.scopuseid_2-s2.0-84902082326-
dc.identifier.hkuros229436-
dc.identifier.hkuros229079-
dc.identifier.volume109-
dc.identifier.issue6-
dc.identifier.spage855-
dc.identifier.epage863-
dc.identifier.isiWOS:000344458900010-
dc.publisher.placeUnited States-

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