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Article: Detection of colorectal adenoma by narrow band imaging (HQ190) vs high-definition white light colonoscopy: a randomized controlled trial

TitleDetection of colorectal adenoma by narrow band imaging (HQ190) vs high-definition white light colonoscopy: a randomized controlled trial
Authors
Issue Date2014
Citation
Am J Gastroenterol, 2014, v. 109 n. 6, p. 855-863 How to Cite?
AbstractOBJECTIVES: The benefits of narrow band imaging (NBI) on enhancing colorectal adenoma detection remain questionable. We tested whether the new generation of NBI (190-NBI), which is twice as bright as the previous version, would improve adenoma detection when compared with high-definition white light (HD-WL) colonoscopy. METHODS: It was a randomized controlled trial with tandem colonoscopy. We recruited patients who underwent colonoscopy for symptoms, screening, or surveillance. Patients were randomized for the use of either 190-NBI or HD-WL on withdrawal. Tandem colonoscopy was performed by using the same assigned colonoscope and withdrawal method. Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates, respectively. The primary outcomes were adenoma and polyp detection rates. RESULTS: A total of 360 patients were randomized to undergo either 190-NBI or HD-WL colonoscopy. Both the adenoma and polyp detection rates were significantly higher in the 190-NBI group compared with the HD-WL group (adenoma: 48.3% vs. 34.4%, P=0.01; polyps: 61.1% vs. 48.3%, P=0.02). The mean number of polyps detected per patient was higher in the 190-NBI group (1.49% vs. 1.13, P=0.07). There was no significant difference in the adenoma miss rates between the two groups (21.8% vs. 21.2%). Multivariate analysis showed that the use of 190-NBI (odds ratio (OR) 1.85; 95% confidence interval (CI) 1.10-3.12), withdrawal time (OR 1.29; CI 1.19-1.38), patient's age (OR 1.04; CI 1.01-1.06), and male gender (OR 2.38; CI 1.42-3.99) were associated with adenoma detection. CONCLUSIONS: 190-NBI colonoscopy was superior to the conventional HD-WL in detecting colorectal adenomas or polyps, but there was no significant difference in adenoma miss rates.
Persistent Identifierhttp://hdl.handle.net/10722/198048
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946

 

DC FieldValueLanguage
dc.contributor.authorLeung, WKen_US
dc.contributor.authorLo, OSHen_US
dc.contributor.authorLiu, KSen_US
dc.contributor.authorTong, Ten_US
dc.contributor.authorBut, YKDen_US
dc.contributor.authorLam, FYen_US
dc.contributor.authorHsu, ASJen_US
dc.contributor.authorWong, SYen_US
dc.contributor.authorSeto, WKWen_US
dc.contributor.authorHung, IFNen_US
dc.contributor.authorLaw, WLen_US
dc.date.accessioned2014-06-25T02:42:10Z-
dc.date.available2014-06-25T02:42:10Z-
dc.date.issued2014en_US
dc.identifier.citationAm J Gastroenterol, 2014, v. 109 n. 6, p. 855-863en_US
dc.identifier.issn0002-9270en_US
dc.identifier.urihttp://hdl.handle.net/10722/198048-
dc.description.abstractOBJECTIVES: The benefits of narrow band imaging (NBI) on enhancing colorectal adenoma detection remain questionable. We tested whether the new generation of NBI (190-NBI), which is twice as bright as the previous version, would improve adenoma detection when compared with high-definition white light (HD-WL) colonoscopy. METHODS: It was a randomized controlled trial with tandem colonoscopy. We recruited patients who underwent colonoscopy for symptoms, screening, or surveillance. Patients were randomized for the use of either 190-NBI or HD-WL on withdrawal. Tandem colonoscopy was performed by using the same assigned colonoscope and withdrawal method. Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates, respectively. The primary outcomes were adenoma and polyp detection rates. RESULTS: A total of 360 patients were randomized to undergo either 190-NBI or HD-WL colonoscopy. Both the adenoma and polyp detection rates were significantly higher in the 190-NBI group compared with the HD-WL group (adenoma: 48.3% vs. 34.4%, P=0.01; polyps: 61.1% vs. 48.3%, P=0.02). The mean number of polyps detected per patient was higher in the 190-NBI group (1.49% vs. 1.13, P=0.07). There was no significant difference in the adenoma miss rates between the two groups (21.8% vs. 21.2%). Multivariate analysis showed that the use of 190-NBI (odds ratio (OR) 1.85; 95% confidence interval (CI) 1.10-3.12), withdrawal time (OR 1.29; CI 1.19-1.38), patient's age (OR 1.04; CI 1.01-1.06), and male gender (OR 2.38; CI 1.42-3.99) were associated with adenoma detection. CONCLUSIONS: 190-NBI colonoscopy was superior to the conventional HD-WL in detecting colorectal adenomas or polyps, but there was no significant difference in adenoma miss rates.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.titleDetection of colorectal adenoma by narrow band imaging (HQ190) vs high-definition white light colonoscopy: a randomized controlled trialen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK: hku75407@hku.hken_US
dc.identifier.emailLo, OSH: oswens@hku.hken_US
dc.identifier.emailBut, YKD: drdbut@hku.hken_US
dc.identifier.emailHsu, ASJ: axelhsu@hku.hken_US
dc.identifier.emailWong, SY: ksywong@hkucc.hku.hken_US
dc.identifier.emailSeto, WKW: wkseto2@hku.hken_US
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_US
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.identifier.authoritySeto, WKW=rp01659en_US
dc.identifier.authorityHung, IFN=rp00508en_US
dc.identifier.authorityLaw, WL=rp00436en_US
dc.identifier.doi10.1038/ajg.2014.83en_US
dc.identifier.hkuros229079en_US
dc.identifier.hkuros229436-
dc.identifier.volume109en_US
dc.identifier.issue6en_US
dc.identifier.spage855en_US
dc.identifier.epage863en_US

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