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Article: New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia

TitleNew susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia
Authors
Issue Date2014
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2014, v. 9 n. 2, article no. e86449 How to Cite?
AbstractPrevious studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB1*09 ratio 01 (P = 1.36 x 10(-6); OR= 1.97; 95% CI, 1.50-2.59) and a new protective allele DPB1*02 ratio 01 (P = 5.22 x 10(-6); OR = 0.68; 95% CI, 0.58-0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02 ratio 01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55 x 10(-7); OR = 0.50; 95% CI, 0.39-0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/198043
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNishida, Nen_US
dc.contributor.authorSawai, Hen_US
dc.contributor.authorKashiwase, Ken_US
dc.contributor.authorMinami, Men_US
dc.contributor.authorSugiyama, Men_US
dc.contributor.authorSeto, WKWen_US
dc.contributor.authorYuen, RMFen_US
dc.contributor.authorPosuwan, Nen_US
dc.contributor.authorPoovorawan, Yen_US
dc.contributor.authorAhn, SHen_US
dc.contributor.authorHan, KHen_US
dc.contributor.authorMatsuura, Ken_US
dc.contributor.authorTanaka, Yen_US
dc.contributor.authorKurosaki, Men_US
dc.contributor.authorAsahina, Yen_US
dc.contributor.authorIzumi, Nen_US
dc.contributor.authorKang, JHen_US
dc.contributor.authorHige, Sen_US
dc.contributor.authorIde, Ten_US
dc.contributor.authorYamamoto, Ken_US
dc.contributor.authorSakaida, Ien_US
dc.contributor.authorMurawaki, Yen_US
dc.contributor.authorItoh, Yen_US
dc.contributor.authorTamori, Aen_US
dc.contributor.authorOrito, Een_US
dc.contributor.authorHiasa, Yen_US
dc.contributor.authorHonda, Men_US
dc.contributor.authorKaneko, Sen_US
dc.contributor.authorMita, Een_US
dc.contributor.authorSuzuki, Ken_US
dc.contributor.authorHino, Ken_US
dc.contributor.authorTanaka, Een_US
dc.contributor.authorMochida, Sen_US
dc.contributor.authorWatanabe, Men_US
dc.contributor.authorEguchi, Yen_US
dc.contributor.authorMasaki, Nen_US
dc.contributor.authorMurata, Ken_US
dc.contributor.authorKorenaga, Men_US
dc.contributor.authorMawatari, Yen_US
dc.contributor.authorOhashi, Jen_US
dc.contributor.authorKawashima, Men_US
dc.contributor.authorTokunaga, Ken_US
dc.contributor.authorMizokami, Men_US
dc.date.accessioned2014-06-25T02:42:07Z-
dc.date.available2014-06-25T02:42:07Z-
dc.date.issued2014en_US
dc.identifier.citationPLoS One, 2014, v. 9 n. 2, article no. e86449en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/198043-
dc.description.abstractPrevious studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB1*09 ratio 01 (P = 1.36 x 10(-6); OR= 1.97; 95% CI, 1.50-2.59) and a new protective allele DPB1*02 ratio 01 (P = 5.22 x 10(-6); OR = 0.68; 95% CI, 0.58-0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02 ratio 01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55 x 10(-7); OR = 0.50; 95% CI, 0.39-0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNew susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asiaen_US
dc.typeArticleen_US
dc.identifier.emailSeto, WKW: wkseto2@hku.hken_US
dc.identifier.emailYuen, RMF: mfyuen@hku.hken_US
dc.identifier.authoritySeto, WKW=rp01659en_US
dc.identifier.authorityYuen, RMF=rp00479en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0086449en_US
dc.identifier.pmid24520320-
dc.identifier.pmcidPMC3919706-
dc.identifier.hkuros229431en_US
dc.identifier.volume9en_US
dc.identifier.issue2en_US
dc.identifier.isiWOS:000331254600011-

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