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Article: A 3.0-kDa low molecular weight heparin promotes gastric ulcer healing in rats

TitleA 3.0-kDa low molecular weight heparin promotes gastric ulcer healing in rats
Authors
KeywordsAnticoagulants - blood - pharmacology
Cell Division - drug effects
Heparin, Low-Molecular-Weight - blood - chemistry - pharmacology
Stomach Ulcer - chemically induced - drug therapy - physiopathology
Wound Healing - drug effects
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology and Therapeutics, 2001, v. 15 n. 12, p. 2009-2017 How to Cite?
AbstractBACKGROUND: Previous studies have shown that intragastric administration of unfractionated heparin enhances gastric ulcer healing in rats. As the large molecule of heparin may be partially degraded in the upper gastrointestinal tract, it is likely that fragments of heparin, derived from the unfractionated parent compound, are involved in the anti-ulcer action in the stomach. Therefore, it is possible that low molecular weight heparin may have a similar ulcer healing effect. METHODS: Male Sprague-Dawley rats with acetic acid-induced gastric ulcers were given a 3.0-kDa low molecular weight heparin (0.6-6.0 mg/kg) intravenously or intragastrically once daily for 4 days. Ulcer healing, mucosal histological changes, angiogenesis and gastric mucus production both in vivo and in vitro were determined. The bleeding time was measured to indicate the anticoagulation activity. RESULTS: Both intravenous and intragastric low molecular weight heparin dose dependently accelerated gastric ulcer healing, which was accompanied by a significant increase in mucosal regeneration and proliferation, angiogenesis and mucus content in the stomach. The drug also stimulated the mucus production in MKN-28 cells. Drug administration by either route did not alter the bleeding time in rats. CONCLUSIONS: A 3.0-kDa low molecular weight heparin possesses an ulcer healing effect similar to that of unfractionated heparin in the stomach of the rat. This smaller molecular drug is superior to the unfractionated form, does not affect the coagulation activity and may show better absorption in the gastrointestinal tract.
Persistent Identifierhttp://hdl.handle.net/10722/197977
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Y-
dc.contributor.authorShin, VY-
dc.contributor.authorCheuk, CY-
dc.contributor.authorLiu, ESL-
dc.contributor.authorCho, CH-
dc.date.accessioned2014-06-19T07:04:13Z-
dc.date.available2014-06-19T07:04:13Z-
dc.date.issued2001-
dc.identifier.citationAlimentary Pharmacology and Therapeutics, 2001, v. 15 n. 12, p. 2009-2017-
dc.identifier.issn0269-2813-
dc.identifier.urihttp://hdl.handle.net/10722/197977-
dc.description.abstractBACKGROUND: Previous studies have shown that intragastric administration of unfractionated heparin enhances gastric ulcer healing in rats. As the large molecule of heparin may be partially degraded in the upper gastrointestinal tract, it is likely that fragments of heparin, derived from the unfractionated parent compound, are involved in the anti-ulcer action in the stomach. Therefore, it is possible that low molecular weight heparin may have a similar ulcer healing effect. METHODS: Male Sprague-Dawley rats with acetic acid-induced gastric ulcers were given a 3.0-kDa low molecular weight heparin (0.6-6.0 mg/kg) intravenously or intragastrically once daily for 4 days. Ulcer healing, mucosal histological changes, angiogenesis and gastric mucus production both in vivo and in vitro were determined. The bleeding time was measured to indicate the anticoagulation activity. RESULTS: Both intravenous and intragastric low molecular weight heparin dose dependently accelerated gastric ulcer healing, which was accompanied by a significant increase in mucosal regeneration and proliferation, angiogenesis and mucus content in the stomach. The drug also stimulated the mucus production in MKN-28 cells. Drug administration by either route did not alter the bleeding time in rats. CONCLUSIONS: A 3.0-kDa low molecular weight heparin possesses an ulcer healing effect similar to that of unfractionated heparin in the stomach of the rat. This smaller molecular drug is superior to the unfractionated form, does not affect the coagulation activity and may show better absorption in the gastrointestinal tract.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT-
dc.relation.ispartofAlimentary Pharmacology and Therapeutics-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectAnticoagulants - blood - pharmacology-
dc.subjectCell Division - drug effects-
dc.subjectHeparin, Low-Molecular-Weight - blood - chemistry - pharmacology-
dc.subjectStomach Ulcer - chemically induced - drug therapy - physiopathology-
dc.subjectWound Healing - drug effects-
dc.titleA 3.0-kDa low molecular weight heparin promotes gastric ulcer healing in ratsen_US
dc.typeArticleen_US
dc.identifier.emailCho, CH: chcho@hkusua.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1365-2036.2001.01112.x-
dc.identifier.pmid11736733-
dc.identifier.scopuseid_2-s2.0-0035662802-
dc.identifier.hkuros73396-
dc.identifier.volume15-
dc.identifier.issue12-
dc.identifier.spage2009-
dc.identifier.epage2017-
dc.identifier.isiWOS:000172788300021-
dc.publisher.placeUnited Kingdom-

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