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Conference Paper: Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis

TitleNovel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis
Authors
KeywordsMedical sciences
Oncology
Issue Date2014
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
The 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. 1565 How to Cite?
AbstractHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ...
DescriptionMolecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565
This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ...
Persistent Identifierhttp://hdl.handle.net/10722/197695
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorKo, FCF-
dc.contributor.authorYeung, YS-
dc.contributor.authorMao, X-
dc.contributor.authorYam, JWP-
dc.date.accessioned2014-05-29T08:42:46Z-
dc.date.available2014-05-29T08:42:46Z-
dc.date.issued2014-
dc.identifier.citationThe 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. 1565-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/197695-
dc.descriptionMolecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565-
dc.descriptionThis journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ...-
dc.description.abstractHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ...-
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/-
dc.relation.ispartofCancer Research-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.subjectOncology-
dc.titleNovel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis-
dc.typeConference_Paper-
dc.identifier.emailKo, FCF: bokcf@hku.hk-
dc.identifier.emailYeung, YS: yeungys@hku.hk-
dc.identifier.emailMao, X: susanmao@hku.hk-
dc.identifier.emailYam, JWP: judyyam@pathology.hku.hk-
dc.identifier.authorityYam, JWP=rp00468-
dc.description.naturepostprint-
dc.identifier.doi10.1158/1538-7445.AM2014-1565-
dc.identifier.hkuros228911-
dc.identifier.volume74-
dc.identifier.issue19 suppl.-
dc.publisher.placeUnited States-

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