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Article: Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis

TitleHealth-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis
Authors
KeywordsSurvival
Recurrence
Quality of life
Prognosis
Competing risks
Colorectal cancer
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/
Citation
BMC Cancer, 2014, v. 14, article no. 337 How to Cite?
AbstractBackground: The study aimed to examine the association between health-related quality of life (HRQOL) assessed with overall survival (OS) and recurrence after diagnosis of colorectal cancer (CRC). Methods: Overall 160 patients with advanced stage CRC were recruited in an observational study and completed the generic and condition-specific HRQOL questionnaires at the colorectal specialist outpatient clinic in Hong Kong, between 10/2009 and 07/2010. Socio-demographic and clinical characteristics including duration since diagnosis, primary tumor location and treatment modality, were collected to serve as predictor variables in regression models. All-cause death or CRC recurrence was the event of interest. Association between HRQOL with OS was assessed using Cox regression. Association between HRQOL and CRC recurrence was further modeled by competing-risks regression adjusted for the competing-risks of death from any cause. Results: After a median follow-up of 23 months, there were 22 (16.1%) incidents of CRC recurrence and 15 (9.4%) deaths. Decreased physical functioning (hazard ratios, HR = 0.917, 95%CI:0.889-0.981) and general health of domains in SF-12 (HR = 0.846, 95%CI:0.746-0.958) or SF-6D scores (HR = 0.010, 95%CI:0.000-0.573) were associated with an increased risk of death, with adjustment of patients' characteristics. Increased vitality (HR = 1.151, 95%CI:1.027-1.289) and mental health (HR = 1.128, 95%CI:1.005-1.265) were associated with an increased likelihood of death. In models adjusted for competing-risk of death, those with worse HRQOL was not associated with increased risk of CRC recurrence. Conclusions: Although self-reported HRQOL was not a significant prognostic factor for CRC recurrence, the HRQOL provided independent prognostic value about mortality in patients with advanced stage of CRC.
Persistent Identifierhttp://hdl.handle.net/10722/197605
PubMed Central ID
ISI Accession Number ID
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DC FieldValueLanguage
dc.contributor.authorWong, CKHen_US
dc.contributor.authorLaw, WLen_US
dc.contributor.authorWan, YFen_US
dc.contributor.authorPoon, TCJen_US
dc.contributor.authorLam, CLKen_US
dc.date.accessioned2014-05-29T08:29:55Z-
dc.date.available2014-05-29T08:29:55Z-
dc.date.issued2014en_US
dc.identifier.citationBMC Cancer, 2014, v. 14, article no. 337en_US
dc.identifier.urihttp://hdl.handle.net/10722/197605-
dc.description.abstractBackground: The study aimed to examine the association between health-related quality of life (HRQOL) assessed with overall survival (OS) and recurrence after diagnosis of colorectal cancer (CRC). Methods: Overall 160 patients with advanced stage CRC were recruited in an observational study and completed the generic and condition-specific HRQOL questionnaires at the colorectal specialist outpatient clinic in Hong Kong, between 10/2009 and 07/2010. Socio-demographic and clinical characteristics including duration since diagnosis, primary tumor location and treatment modality, were collected to serve as predictor variables in regression models. All-cause death or CRC recurrence was the event of interest. Association between HRQOL with OS was assessed using Cox regression. Association between HRQOL and CRC recurrence was further modeled by competing-risks regression adjusted for the competing-risks of death from any cause. Results: After a median follow-up of 23 months, there were 22 (16.1%) incidents of CRC recurrence and 15 (9.4%) deaths. Decreased physical functioning (hazard ratios, HR = 0.917, 95%CI:0.889-0.981) and general health of domains in SF-12 (HR = 0.846, 95%CI:0.746-0.958) or SF-6D scores (HR = 0.010, 95%CI:0.000-0.573) were associated with an increased risk of death, with adjustment of patients' characteristics. Increased vitality (HR = 1.151, 95%CI:1.027-1.289) and mental health (HR = 1.128, 95%CI:1.005-1.265) were associated with an increased likelihood of death. In models adjusted for competing-risk of death, those with worse HRQOL was not associated with increased risk of CRC recurrence. Conclusions: Although self-reported HRQOL was not a significant prognostic factor for CRC recurrence, the HRQOL provided independent prognostic value about mortality in patients with advanced stage of CRC.en_US
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/-
dc.relation.ispartofBMC Canceren_US
dc.rightsBMC Cancer. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectSurvival-
dc.subjectRecurrence-
dc.subjectQuality of life-
dc.subjectPrognosis-
dc.subjectCompeting risks-
dc.subjectColorectal cancer-
dc.titleHealth-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosisen_US
dc.typeArticleen_US
dc.identifier.emailWong, CKH: carlosho@hku.hken_US
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_US
dc.identifier.emailWan, YF: yfwan@hku.hken_US
dc.identifier.emailPoon, TCJ: tcjensen@hku.hken_US
dc.identifier.emailLam, CLK: clklam@hku.hken_US
dc.identifier.authorityLaw, WL=rp00436en_US
dc.identifier.authorityPoon, TCJ=rp01603en_US
dc.identifier.authorityLam, CLK=rp00350en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2407-14-337en_US
dc.identifier.pmid24886385-
dc.identifier.pmcidPMC4030731-
dc.identifier.scopuseid_2-s2.0-84901263891-
dc.identifier.hkuros228979en_US
dc.identifier.volume14en_US
dc.identifier.spage337en_US
dc.identifier.epage337en_US
dc.identifier.isiWOS:000336812100001-
dc.relation.projectA Study on Health-related Quality of Life of patients with Colorectal Neoplasm and Cost-Effectiveness Analysis of Colorectal Cancer Screening in Hong Kong-

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