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Article: Dose-response relationship between smoking status and carotid atherosclerosis (in Chinese)

TitleDose-response relationship between smoking status and carotid atherosclerosis (in Chinese)
男性吸烟状况与颈动脉粥样硬化的剂量-反应关系研究
Authors
Issue Date2010
PublisherChinese Medical Association [中華醫學會]. The Journal's web site is located at http://zhlxbx.periodicals.net.cn/
Citation
中華流行病學雜誌, 2010, v. 31 n. 9, p. 983-987 How to Cite?
Chinese Journal of Epidemiology, 2010, v. 31 n. 9, p. 983-987 How to Cite?
AbstractOBJECTIVE: To examine the dose-response relationship of smoking status with carotid atherosclerosis in 959 relatively healthy Chinese men. METHODS: 959 older Chinese men were selected from Guangzhou Biobank Cohort Study (GBCS) on cardiovascular disease. Personal histories were collected and fasting plasma glucose and lipids, blood pressure, and common carotid artery intima-median thickness (CCA-IMT) were measured. RESULTS: (1) Composition of the cases: 39.1% were non-smokers, 25.7% were former smokers and 35.2% were current smokers. The mean (95% confidence interval) carotid IMT was 0.78 (0.77 - 0.79) mm. 18.4% of the subjects had carotid IMT equal to or thicker than 1.0 mm while 34.1% had carotid plaque. (2) After adjusting for age, sex, physical activity, body mass index, fasting glucose, triglyceride, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, compared to never smokers, current smokers had significantly increased risk for thicker IMT and carotid plaque [odds ratio (OR) = 1.82, 95%CI: 1.30 - 2.55 and OR = 1.95, 95%CI: 1.38 - 2.75, respectively, all P < 0.001]. The risk for thicker IMT and carotid plaque increased with the increasing amount (cigarettes/day) and duration of smoking (years) as well with cigarette pack-years (P for trend all
Persistent Identifierhttp://hdl.handle.net/10722/197272
ISSN
2015 SCImago Journal Rankings: 0.191

 

DC FieldValueLanguage
dc.contributor.authorJiang, CQen_US
dc.contributor.authorXu, Len_US
dc.contributor.authorLin, JMen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorJin, YLen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorThomas, GNen_US
dc.date.accessioned2014-05-23T02:32:05Z-
dc.date.available2014-05-23T02:32:05Z-
dc.date.issued2010en_US
dc.identifier.citation中華流行病學雜誌, 2010, v. 31 n. 9, p. 983-987en_US
dc.identifier.citationChinese Journal of Epidemiology, 2010, v. 31 n. 9, p. 983-987-
dc.identifier.issn0254-6450-
dc.identifier.urihttp://hdl.handle.net/10722/197272-
dc.description.abstractOBJECTIVE: To examine the dose-response relationship of smoking status with carotid atherosclerosis in 959 relatively healthy Chinese men. METHODS: 959 older Chinese men were selected from Guangzhou Biobank Cohort Study (GBCS) on cardiovascular disease. Personal histories were collected and fasting plasma glucose and lipids, blood pressure, and common carotid artery intima-median thickness (CCA-IMT) were measured. RESULTS: (1) Composition of the cases: 39.1% were non-smokers, 25.7% were former smokers and 35.2% were current smokers. The mean (95% confidence interval) carotid IMT was 0.78 (0.77 - 0.79) mm. 18.4% of the subjects had carotid IMT equal to or thicker than 1.0 mm while 34.1% had carotid plaque. (2) After adjusting for age, sex, physical activity, body mass index, fasting glucose, triglyceride, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, compared to never smokers, current smokers had significantly increased risk for thicker IMT and carotid plaque [odds ratio (OR) = 1.82, 95%CI: 1.30 - 2.55 and OR = 1.95, 95%CI: 1.38 - 2.75, respectively, all P < 0.001]. The risk for thicker IMT and carotid plaque increased with the increasing amount (cigarettes/day) and duration of smoking (years) as well with cigarette pack-years (P for trend all </= 0.01). CONCLUSION: An elevated risk with a clear dose-response relationship was found between cigarette smoking and carotid atherosclerosis. Quitting smoking or reducing the amount of smoking may lower the risk of atherosclerosis, preventing and controlling the occurrence of cardiovascular diseases, and reducing the related cardiovascular mortalities.-
dc.languagechien_US
dc.publisherChinese Medical Association [中華醫學會]. The Journal's web site is located at http://zhlxbx.periodicals.net.cn/-
dc.relation.ispartof中華流行病學雜誌en_US
dc.relation.ispartofChinese Journal of Epidemiology-
dc.subject.meshCarotid Artery Diseases - etiology-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking - adverse effects-
dc.subject.meshTunica Intima-
dc.titleDose-response relationship between smoking status and carotid atherosclerosis (in Chinese)en_US
dc.title男性吸烟状况与颈动脉粥样硬化的剂量-反应关系研究-
dc.typeArticleen_US
dc.identifier.emailJiang, CQ: cqjiang@HKUCC.hku.hken_US
dc.identifier.emailXu, L: xulin@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailZhang, W: zhangws9@HKUCC-COM.hku.hken_US
dc.identifier.emailCheng, KK: chengkk@HKUCC.hku.hken_US
dc.identifier.emailThomas, GN: neilt@HKUCC.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.doi10.3760/cma.j.issn.0254-6450.2010.09.006-
dc.identifier.pmid21162860-
dc.identifier.hkuros183886en_US
dc.identifier.volume31en_US
dc.identifier.issue9en_US
dc.identifier.spage983en_US
dc.identifier.epage987en_US
dc.publisher.placeChina-

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