File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Life expectancy, Standardized Mortality Ratios, and causes of death in Six Rheumatic Diseases in Hong Kong, China.

TitleLife expectancy, Standardized Mortality Ratios, and causes of death in Six Rheumatic Diseases in Hong Kong, China.
Authors
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation
Arthritis & Rheumatism, 2011, v. 63 n. 5, p. 1182-1189 How to Cite?
AbstractOBJECTIVE: To examine the life expectancy, standardized mortality ratios (SMRs), and causes of death in 6 groups of patients from Hong Kong with different rheumatic diseases. METHODS: Patients with a diagnosis of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), systemic vasculitis (SV), or systemic sclerosis (SSc) registered in 37 public hospitals between 1999 and 2008 were identified in the hospital registry. SMRs were calculated by comparing the mortality rate in patients with each disease with that in the general population. Life expectancy was calculated by abridged life-table analysis, and the causes of death were compared. RESULTS: In 2008, data on 8,367 RA, 5,243 SLE, 2,154 AS, 1,636 SV, 778 PsA, and 449 SSc patients were available in our registry. The age- and sex-adjusted SMRs were highest for SLE (5.25 [95% confidence interval 4.79-5.70]), SSc (3.94 [95% confidence interval 3.20-4.68]), and SV (2.64 [95% confidence interval 2.36-2.93]). In female patients, the loss in life expectancy was greatest for SSc (34.1 years), SV (19.3 years), and SLE (19.7 years). In male patients, the loss in life expectancy was highest for SV (28.3 years), SLE (27 years), and SSc (16 years). There were 2,486 deaths during the study period (1999-2008), and the principal causes were infections (28%), cardiovascular complications (18%), cancer (16%), and disease activity (7%). Infection was the leading cause of death in SLE, RA, AS, and PsA, whereas deaths from disease-related activity and cardiovascular complications were most frequent in SSc. Cancer was the most common cause of death in SV. CONCLUSION: Our findings indicate that patients with SLE, RA, AS, PsA, SV, and SSc have increased mortality rates and reduced life expectancy. SLE has the highest adjusted SMR, and female SSc patients have the greatest loss in life expectancy. Infection is the leading cause of death, followed by cardiovascular complications and malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/197250
ISSN
2015 Impact Factor: 8.955
2015 SCImago Journal Rankings: 3.206
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMok, CCen_US
dc.contributor.authorKwok, CLen_US
dc.contributor.authorHo, LYen_US
dc.contributor.authorChan, PTen_US
dc.contributor.authorYip, PSFen_US
dc.date.accessioned2014-05-23T02:29:43Z-
dc.date.available2014-05-23T02:29:43Z-
dc.date.issued2011en_US
dc.identifier.citationArthritis & Rheumatism, 2011, v. 63 n. 5, p. 1182-1189en_US
dc.identifier.issn0004-3591en_US
dc.identifier.urihttp://hdl.handle.net/10722/197250-
dc.description.abstractOBJECTIVE: To examine the life expectancy, standardized mortality ratios (SMRs), and causes of death in 6 groups of patients from Hong Kong with different rheumatic diseases. METHODS: Patients with a diagnosis of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), systemic vasculitis (SV), or systemic sclerosis (SSc) registered in 37 public hospitals between 1999 and 2008 were identified in the hospital registry. SMRs were calculated by comparing the mortality rate in patients with each disease with that in the general population. Life expectancy was calculated by abridged life-table analysis, and the causes of death were compared. RESULTS: In 2008, data on 8,367 RA, 5,243 SLE, 2,154 AS, 1,636 SV, 778 PsA, and 449 SSc patients were available in our registry. The age- and sex-adjusted SMRs were highest for SLE (5.25 [95% confidence interval 4.79-5.70]), SSc (3.94 [95% confidence interval 3.20-4.68]), and SV (2.64 [95% confidence interval 2.36-2.93]). In female patients, the loss in life expectancy was greatest for SSc (34.1 years), SV (19.3 years), and SLE (19.7 years). In male patients, the loss in life expectancy was highest for SV (28.3 years), SLE (27 years), and SSc (16 years). There were 2,486 deaths during the study period (1999-2008), and the principal causes were infections (28%), cardiovascular complications (18%), cancer (16%), and disease activity (7%). Infection was the leading cause of death in SLE, RA, AS, and PsA, whereas deaths from disease-related activity and cardiovascular complications were most frequent in SSc. Cancer was the most common cause of death in SV. CONCLUSION: Our findings indicate that patients with SLE, RA, AS, PsA, SV, and SSc have increased mortality rates and reduced life expectancy. SLE has the highest adjusted SMR, and female SSc patients have the greatest loss in life expectancy. Infection is the leading cause of death, followed by cardiovascular complications and malignancies.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/en_US
dc.relation.ispartofArthritis & Rheumatismen_US
dc.rightsArthritis & Rheumatism. Copyright © John Wiley & Sons, Inc.en_US
dc.subject.meshCause of Deathen_US
dc.subject.meshHong Kong - epidemiologyen_US
dc.subject.meshLife Expectancyen_US
dc.subject.meshRheumatic Diseases - mortalityen_US
dc.subject.meshSex Factorsen_US
dc.titleLife expectancy, Standardized Mortality Ratios, and causes of death in Six Rheumatic Diseases in Hong Kong, China.en_US
dc.typeArticleen_US
dc.identifier.emailYip, PSF: sfpyip@hku.hken_US
dc.identifier.authorityYip, PSF=rp00596en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/art.30277en_US
dc.identifier.pmid21391198en_US
dc.identifier.hkuros221424en_US
dc.identifier.hkuros253807-
dc.identifier.volume63en_US
dc.identifier.issue5en_US
dc.identifier.spage1182en_US
dc.identifier.epage1189en_US
dc.identifier.isiWOS:000290609800005-
dc.publisher.placeUnited Statesen_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats