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Article: Membranous lupus nephritis in Chinese children - a case series and review of the literature

TitleMembranous lupus nephritis in Chinese children - a case series and review of the literature
Authors
Issue Date2009
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htm
Citation
Pediatric Nephrology, 2009, v. 24 n. 10, p. 1989-1996 How to Cite?
AbstractWe retrospectively reviewed the cases of 13 lupus nephritis children with pure membranous glomerulonephritis (MGN; Group A) and ten children with mixed proliferative and membranous nephritis (Group B). The children were identified through a territory-wide survey of patients between 1990 and 2003. All were ethnic Chinese. Age at diagnosis ranged from 3.7 to 18.6 years (Group A) and from 9.6 to 22.1 years (Group B). Female-to-male ratios were 12:1 (Group A) and 9:1 (Group B). Group A patients were more often nephrotic than Group B patients (11/13 vs. 5/10, p = 0.17). The glomerular filtration rate (GFR) at presentation was normal in all but two patients (one from each group). For induction, Group B patients consistently received prednisolone and cyclophosphamide; in contrast, the cytotoxic regimens in Group A patients varied from cyclophosphamide (five patients), mycophenolate mofetil (two patients), azathiorpine plus cyclosporine (one patient), and azathioprine alone (one patient). After a median follow-up of 7.6-7.8 years, one Group A patient had died of fulminant lupus. One survivor in Group B had a GFR < 90 ml/min per 1.73 m(2). Proteinuria persisted in five Group A patients and two Group B patients. In conclusion, Group B patients had good prognosis in terms of survival and proteinuria control. The only death occurred in Group A, and five of the 12 survivors in this group had persistent proteinuria. Further studies are needed to define the best treatment for pure lupus MGN.
Persistent Identifierhttp://hdl.handle.net/10722/197238
ISSN
2015 Impact Factor: 2.338
2015 SCImago Journal Rankings: 0.959
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, SNen_US
dc.contributor.authorChan, WKYen_US
dc.contributor.authorHui, Jen_US
dc.contributor.authorChim, Sen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorLee, KPen_US
dc.contributor.authorLeung, LCKen_US
dc.contributor.authorTse, NKCen_US
dc.contributor.authorSo, YFen_US
dc.date.accessioned2014-05-23T02:28:14Z-
dc.date.available2014-05-23T02:28:14Z-
dc.date.issued2009en_US
dc.identifier.citationPediatric Nephrology, 2009, v. 24 n. 10, p. 1989-1996en_US
dc.identifier.issn0931-041Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/197238-
dc.description.abstractWe retrospectively reviewed the cases of 13 lupus nephritis children with pure membranous glomerulonephritis (MGN; Group A) and ten children with mixed proliferative and membranous nephritis (Group B). The children were identified through a territory-wide survey of patients between 1990 and 2003. All were ethnic Chinese. Age at diagnosis ranged from 3.7 to 18.6 years (Group A) and from 9.6 to 22.1 years (Group B). Female-to-male ratios were 12:1 (Group A) and 9:1 (Group B). Group A patients were more often nephrotic than Group B patients (11/13 vs. 5/10, p = 0.17). The glomerular filtration rate (GFR) at presentation was normal in all but two patients (one from each group). For induction, Group B patients consistently received prednisolone and cyclophosphamide; in contrast, the cytotoxic regimens in Group A patients varied from cyclophosphamide (five patients), mycophenolate mofetil (two patients), azathiorpine plus cyclosporine (one patient), and azathioprine alone (one patient). After a median follow-up of 7.6-7.8 years, one Group A patient had died of fulminant lupus. One survivor in Group B had a GFR < 90 ml/min per 1.73 m(2). Proteinuria persisted in five Group A patients and two Group B patients. In conclusion, Group B patients had good prognosis in terms of survival and proteinuria control. The only death occurred in Group A, and five of the 12 survivors in this group had persistent proteinuria. Further studies are needed to define the best treatment for pure lupus MGN.-
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htmen_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.rightsThe original publication is available at www.springerlink.comen_US
dc.subject.meshCyclosporins - therapeutic use-
dc.subject.meshDrug Therapy, Combination-
dc.subject.meshGlomerular Filtration Rate-
dc.subject.meshImmunosuppressive Agents - therapeutic use-
dc.subject.meshLupus Nephritis - drug therapy - physiopathology-
dc.titleMembranous lupus nephritis in Chinese children - a case series and review of the literatureen_US
dc.typeArticleen_US
dc.identifier.emailWong, SN: snwong@hkucc.hku.hken_US
dc.identifier.emailChim, S: schim@HKUCC.hku.hken_US
dc.identifier.emailLee, TL: leetsz@HKUCC.hku.hken_US
dc.identifier.doi10.1007/s00467-009-1257-z-
dc.identifier.pmid19626343-
dc.identifier.hkuros168369en_US
dc.identifier.volume24en_US
dc.identifier.issue10-
dc.identifier.spage1989en_US
dc.identifier.epage1996en_US
dc.identifier.isiWOS:000269312900011-
dc.publisher.placeGermanyen_US

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