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Article: The Renin-angiotensin system and reactive oxygen species: implications in pancreatitis

TitleThe Renin-angiotensin system and reactive oxygen species: implications in pancreatitis
Authors
Issue Date2011
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ars
Citation
Antioxidants & Redox Signaling, 2011, v. 15 n. 10, p. 2743-55 How to Cite?
AbstractSIGNIFICANCE: The renin-angiotensin system (RAS) is a circulating hormonal system involved in the regulation of blood pressure and circulating fluid electrolytes. Recent findings have revealed that locally generated angiotensin (Ang) II plays a pivotal role in normal physiology as well as pathophysiology in various tissues and organs, including the pancreas. This review article summarizes current progress that has been made in elucidating the putative roles of Ang II in both acute and chronic pancreatitis. RECENT ADVANCES: A convergence of evidence suggests that the underlying mechanism may involve reactive oxygen species (ROS)-generating systems, such as nicotinamide adenine dinucleotide phosphate oxidase, and subsequent elevation of proinflammatory and profibrogenic gene expression as well as protein activity. More importantly, Ang II-induced ROS interacts with other ROS-generating systems to positively feed-forward the ROS-induced signaling. CRITICAL ISSUES AND FUTURE DIRECTIONS: Advances in basic research indicate that RAS blockers may provide potential therapeutic role for the management of pancreatic inflammation and, more importantly, pancreatitis-associated complications. Genetic alterations resulting from a malfunction in the epigenetic control of pancreatic RAS could be a causative factor in the development of pancreatitis.
Persistent Identifierhttp://hdl.handle.net/10722/197232
ISSN
2015 Impact Factor: 7.093
2015 SCImago Journal Rankings: 3.134
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, YCen_US
dc.contributor.authorLeung, PSen_US
dc.date.accessioned2014-05-23T02:27:36Z-
dc.date.available2014-05-23T02:27:36Z-
dc.date.issued2011en_US
dc.identifier.citationAntioxidants & Redox Signaling, 2011, v. 15 n. 10, p. 2743-55en_US
dc.identifier.issn1523-0864en_US
dc.identifier.urihttp://hdl.handle.net/10722/197232-
dc.description.abstractSIGNIFICANCE: The renin-angiotensin system (RAS) is a circulating hormonal system involved in the regulation of blood pressure and circulating fluid electrolytes. Recent findings have revealed that locally generated angiotensin (Ang) II plays a pivotal role in normal physiology as well as pathophysiology in various tissues and organs, including the pancreas. This review article summarizes current progress that has been made in elucidating the putative roles of Ang II in both acute and chronic pancreatitis. RECENT ADVANCES: A convergence of evidence suggests that the underlying mechanism may involve reactive oxygen species (ROS)-generating systems, such as nicotinamide adenine dinucleotide phosphate oxidase, and subsequent elevation of proinflammatory and profibrogenic gene expression as well as protein activity. More importantly, Ang II-induced ROS interacts with other ROS-generating systems to positively feed-forward the ROS-induced signaling. CRITICAL ISSUES AND FUTURE DIRECTIONS: Advances in basic research indicate that RAS blockers may provide potential therapeutic role for the management of pancreatic inflammation and, more importantly, pancreatitis-associated complications. Genetic alterations resulting from a malfunction in the epigenetic control of pancreatic RAS could be a causative factor in the development of pancreatitis.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/arsen_US
dc.relation.ispartofAntioxidants & Redox Signalingen_US
dc.rightsThis is a copy of an article published in the [JOURNAL TITLE] © [year of publication] [copyright Mary Ann Liebert, Inc.]; [JOURNAL TITLE] is available online at: http://www.liebertonline.com.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshPancreatitis - metabolism - physiopathologyen_US
dc.subject.meshReactive Oxygen Species - metabolismen_US
dc.subject.meshRenin-Angiotensin Systemen_US
dc.titleThe Renin-angiotensin system and reactive oxygen species: implications in pancreatitisen_US
dc.typeArticleen_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1089/ars.2011.4071en_US
dc.identifier.pmid21644836-
dc.identifier.scopuseid_2-s2.0-80054011428-
dc.identifier.hkuros221318en_US
dc.identifier.volume15en_US
dc.identifier.issue10en_US
dc.identifier.spage2743en_US
dc.identifier.epage55en_US
dc.identifier.isiWOS:000295734400008-
dc.publisher.placeUnited Statesen_US

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