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Article: Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort.

TitleElevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort.
Authors
Issue Date2009
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PAI
Citation
Pediatric Allergy and Immunology, 2009, v. 20 n. 8, p. 710-713 How to Cite?
AbstractThere is considerable interest in identifying children at high risk for developing atopic diseases for primary prevention. This study evaluates risk factors for detectable cord blood IgE and assesses CB-IgE in predicting asthma and other IgE-mediated allergic diseases in children at high risk because of family history. Cord blood was obtained as part of a randomized controlled trial assessing the efficacy of an intervention program in the primary prevention of IgE-mediated allergic diseases. CB-IgE was measured and the degree to which this was associated with perinatal risk factors was assessed. The cohort was then evaluated for atopic disorders at 7 yrs of age to assess the predictive value of CB-IgE. Fifty-five (19.3%) of infants had detectable CB-IgE (>/=0.5 kU/l). Maternal atopy and birth in winter months were risk factors associated with detectable CB-IgE. CB-IgE was found to be significantly associated with allergic sensitization (OR 2.22; 95% CI 1.11, 4.41) and recurrent wheeze at 7 yrs (OR 2.51, 95% CI 1.09, 5.76) but not with other outcomes. CB-IgE may be a useful measure for identifying children at high risk of atopic diseases for the purpose of primary prevention.
Persistent Identifierhttp://hdl.handle.net/10722/197225
ISSN
2015 Impact Factor: 3.947
2015 SCImago Journal Rankings: 1.689
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFerguson, Aen_US
dc.contributor.authorDimich-Ward, Hen_US
dc.contributor.authorBecker, Aen_US
dc.contributor.authorWatson, Wen_US
dc.contributor.authorDybuncio, Aen_US
dc.contributor.authorCarlsten, Cen_US
dc.contributor.authorChan, MMWen_US
dc.date.accessioned2014-05-23T02:27:32Z-
dc.date.available2014-05-23T02:27:32Z-
dc.date.issued2009en_US
dc.identifier.citationPediatric Allergy and Immunology, 2009, v. 20 n. 8, p. 710-713en_US
dc.identifier.issn0905-6157-
dc.identifier.urihttp://hdl.handle.net/10722/197225-
dc.description.abstractThere is considerable interest in identifying children at high risk for developing atopic diseases for primary prevention. This study evaluates risk factors for detectable cord blood IgE and assesses CB-IgE in predicting asthma and other IgE-mediated allergic diseases in children at high risk because of family history. Cord blood was obtained as part of a randomized controlled trial assessing the efficacy of an intervention program in the primary prevention of IgE-mediated allergic diseases. CB-IgE was measured and the degree to which this was associated with perinatal risk factors was assessed. The cohort was then evaluated for atopic disorders at 7 yrs of age to assess the predictive value of CB-IgE. Fifty-five (19.3%) of infants had detectable CB-IgE (>/=0.5 kU/l). Maternal atopy and birth in winter months were risk factors associated with detectable CB-IgE. CB-IgE was found to be significantly associated with allergic sensitization (OR 2.22; 95% CI 1.11, 4.41) and recurrent wheeze at 7 yrs (OR 2.51, 95% CI 1.09, 5.76) but not with other outcomes. CB-IgE may be a useful measure for identifying children at high risk of atopic diseases for the purpose of primary prevention.-
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PAI-
dc.relation.ispartofPediatric Allergy and Immunologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshAsthma - epidemiology - prevention and control-
dc.subject.meshFetal Blood - immunology-
dc.subject.meshHypersensitivity, Immediate - epidemiology - prevention and control-
dc.subject.meshImmunoglobulin E - blood-
dc.subject.meshRespiratory Sounds - immunology-
dc.titleElevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort.en_US
dc.typeArticleen_US
dc.identifier.emailChan, MMW: mmwchan@hku.hken_US
dc.identifier.doi10.1111/j.1399-3038.2009.00869.x-
dc.identifier.pmid19236604-
dc.identifier.hkuros162564en_US
dc.identifier.volume20-
dc.identifier.issue8-
dc.identifier.spage710-
dc.identifier.epage713-
dc.identifier.isiWOS:000272307100002-
dc.publisher.placeDenmark-

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