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Article: Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells

TitleAnti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells
Authors
Issue Date2014
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral
Citation
Antiviral Research, 2014, v. 106 n. 1, p. 95–104 How to Cite?
AbstractHuman disease caused by highly pathogenic avian influenza A (HPAI) (H5N1) is associated with fulminant viral pneumonia and mortality rates in excess of 60%. Acute respiratory syndrome (ARDS) has been found to be the most severe form of acute lung injury caused by H5N1 virus infection while cytokine dysregulation and viral replication are thought to contribute to its pathogenesis. In this study, the antiviral and anti-inflammatory effects of two indirubin derivatives: indirubin-3'-oxime (IM) and E804 on primary human peripherial blood-derived macrophages and type-I like pneumocytes (human alveolar epithelial cells) during influenza A (H5N1) virus infection were investigated. We found that both of the indirubin derivatives strongly suppress the pro-inflammatory cytokines including IP-10 (CXCL10), one of the key factors which contribute to the lung inflammation during H5N1 virus infection. In addition, we also demonstrated that the indirubin derivative delays the virus replication in the primary cell culture models. Our results showed that indirubin derivatives have a potential to be used as an adjunct to antiviral therapy for the treatment of severe human H5N1 disease.
Persistent Identifierhttp://hdl.handle.net/10722/196917
ISSN
2015 Impact Factor: 4.909
2015 SCImago Journal Rankings: 2.080
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMok, KPen_US
dc.contributor.authorKang, SRen_US
dc.contributor.authorChan, WYen_US
dc.contributor.authorYue, YKen_US
dc.contributor.authorMak, NKen_US
dc.contributor.authorPoon, LLMen_US
dc.contributor.authorWong, NSen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorChan, MCWen_US
dc.date.accessioned2014-04-29T03:50:39Z-
dc.date.available2014-04-29T03:50:39Z-
dc.date.issued2014-
dc.identifier.citationAntiviral Research, 2014, v. 106 n. 1, p. 95–104en_US
dc.identifier.issn0166-3542-
dc.identifier.urihttp://hdl.handle.net/10722/196917-
dc.description.abstractHuman disease caused by highly pathogenic avian influenza A (HPAI) (H5N1) is associated with fulminant viral pneumonia and mortality rates in excess of 60%. Acute respiratory syndrome (ARDS) has been found to be the most severe form of acute lung injury caused by H5N1 virus infection while cytokine dysregulation and viral replication are thought to contribute to its pathogenesis. In this study, the antiviral and anti-inflammatory effects of two indirubin derivatives: indirubin-3'-oxime (IM) and E804 on primary human peripherial blood-derived macrophages and type-I like pneumocytes (human alveolar epithelial cells) during influenza A (H5N1) virus infection were investigated. We found that both of the indirubin derivatives strongly suppress the pro-inflammatory cytokines including IP-10 (CXCL10), one of the key factors which contribute to the lung inflammation during H5N1 virus infection. In addition, we also demonstrated that the indirubin derivative delays the virus replication in the primary cell culture models. Our results showed that indirubin derivatives have a potential to be used as an adjunct to antiviral therapy for the treatment of severe human H5N1 disease.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral-
dc.relation.ispartofAntiviral Researchen_US
dc.titleAnti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cellsen_US
dc.typeArticleen_US
dc.identifier.emailMok, KP: ch02mkp@hkucc.hku.hken_US
dc.identifier.emailKang, SR: sarakang@hku.hken_US
dc.identifier.emailChan, WY: reneewy@hku.hken_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.emailChan, MCW: mchan@hku.hken_US
dc.identifier.authorityMok, KP=rp01805en_US
dc.identifier.authorityChan, WY=rp01596en_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.authorityChan, MCW=rp00420en_US
dc.identifier.doi10.1016/j.antiviral.2014.03.019en_US
dc.identifier.pmid24717263-
dc.identifier.scopuseid_2-s2.0-84898939549-
dc.identifier.hkuros228684en_US
dc.identifier.volume106en_US
dc.identifier.issue1-
dc.identifier.spage95en_US
dc.identifier.epage104en_US
dc.identifier.isiWOS:000336827700012-
dc.publisher.placeNetherlands-

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