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Article: Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis

TitleGenes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis
Authors
Issue Date2014
PublisherElsevier B.V.. The Journal's web site is located at http://www.elsevier.com/locate/gene
Citation
Gene, 2014 How to Cite?
AbstractChronic glomerulonephritis (CGN) is one of the most severe kidney diseases. Genes of vascular reactivity are thought to play an important role in development and progression of CGN. In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and 304 healthy subjects of population control. Ten polymorphisms of ten genes of vascular homeostasis were genotyped through polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) analysis and TaqMan assays. Association of the genotypes with renal survival was analyzed by the Kaplan–Meier estimator. Genotypes 311SC and 311SS of the PON2 gene, (− 1166)AC and (− 1166)CC of the AGTR1 gene, (+ 46)AA of the ADRB2 gene, and 198KK and 198KN of the EDN1 gene were associated with decreased rate of renal survival of the patients. Polymorphisms S311C PON2, (− 1166)A/C AGTR1, (+ 46)G/A ADRB2, and K198N EDN1 were associated with the accelerated decline in kidney function in the CGN patients.
Persistent Identifierhttp://hdl.handle.net/10722/196824
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLitovkina, Oen_US
dc.contributor.authorNekipelova, Een_US
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorPolonikov, Aen_US
dc.contributor.authorEfremova, Oen_US
dc.contributor.authorZhernakova, Nen_US
dc.contributor.authorReshetnikov, Een_US
dc.contributor.authorChurnosov, Men_US
dc.date.accessioned2014-04-29T03:44:51Z-
dc.date.available2014-04-29T03:44:51Z-
dc.date.issued2014en_US
dc.identifier.citationGene, 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/196824-
dc.description.abstractChronic glomerulonephritis (CGN) is one of the most severe kidney diseases. Genes of vascular reactivity are thought to play an important role in development and progression of CGN. In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and 304 healthy subjects of population control. Ten polymorphisms of ten genes of vascular homeostasis were genotyped through polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) analysis and TaqMan assays. Association of the genotypes with renal survival was analyzed by the Kaplan–Meier estimator. Genotypes 311SC and 311SS of the PON2 gene, (− 1166)AC and (− 1166)CC of the AGTR1 gene, (+ 46)AA of the ADRB2 gene, and 198KK and 198KN of the EDN1 gene were associated with decreased rate of renal survival of the patients. Polymorphisms S311C PON2, (− 1166)A/C AGTR1, (+ 46)G/A ADRB2, and K198N EDN1 were associated with the accelerated decline in kidney function in the CGN patients.en_US
dc.languageengen_US
dc.publisherElsevier B.V.. The Journal's web site is located at http://www.elsevier.com/locate/geneen_US
dc.relation.ispartofGeneen_US
dc.titleGenes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritisen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.identifier.doi10.1016/j.gene.2014.04.020en_US
dc.identifier.pmid24727057-
dc.identifier.hkuros228681en_US
dc.identifier.isiWOS:000338412000017-

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