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Article: Cloning and characterization of muscle-specific kinase in chicken

TitleCloning and characterization of muscle-specific kinase in chicken
Authors
Issue Date2000
Citation
Molecular and Cellular Neuroscience, 2000, v. 16 n. 5, p. 661-673 How to Cite?
AbstractMuscle-specific kinase (MuSK) is part of the receptor complex that is involved in the agrin-induced formation of the neuromuscular junction. In the rodent, prominent mRNA expression of MuSK is restricted to skeletal muscle while the expression of agrin can also be detected in brain and certain nonneuronal tissues. The recent identification of Xenopus MuSK reveals that MuSK can be detected in tissues other than skeletal muscle, such as the neural tube, eye vesicles, and spleen. I this study, we describe the cloning and characterization of the chicken ortholog of MuSK and demonstrate that the regulation of MuSK expression in muscle is conserved from avian to rodent. Abundant mRNA expression of MuSK can be detected in early embryonic chick muscle and is up-regulated after nerve injury. More importantly, we also demonstrate that, in the chicken, MuSK mRNA is expressed during development in brain and liver, suggesting possible novel functions for MuSK. Furthermore, the regulatory profile of MuSK expression in chick muscle closely parallels that observed for acetylcholine receptor, in terms of both mRNA expression and protein localization. Finally, studies with paralyzed chicken muscle as well as with cultured chick myotubes demonstrate the dependence of MuSK on both electrical activity and trophic factors.
Persistent Identifierhttp://hdl.handle.net/10722/196642
ISSN
2015 Impact Factor: 3.597
2015 SCImago Journal Rankings: 2.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, FCF-
dc.contributor.authorGlass, DG-
dc.contributor.authorGies, DR-
dc.contributor.authorCheung, J-
dc.contributor.authorLai, K-O-
dc.contributor.authorFu, AKY-
dc.contributor.authorYancopoulos, GD-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:30Z-
dc.date.available2014-04-24T02:10:30Z-
dc.date.issued2000-
dc.identifier.citationMolecular and Cellular Neuroscience, 2000, v. 16 n. 5, p. 661-673-
dc.identifier.issn1044-7431-
dc.identifier.urihttp://hdl.handle.net/10722/196642-
dc.description.abstractMuscle-specific kinase (MuSK) is part of the receptor complex that is involved in the agrin-induced formation of the neuromuscular junction. In the rodent, prominent mRNA expression of MuSK is restricted to skeletal muscle while the expression of agrin can also be detected in brain and certain nonneuronal tissues. The recent identification of Xenopus MuSK reveals that MuSK can be detected in tissues other than skeletal muscle, such as the neural tube, eye vesicles, and spleen. I this study, we describe the cloning and characterization of the chicken ortholog of MuSK and demonstrate that the regulation of MuSK expression in muscle is conserved from avian to rodent. Abundant mRNA expression of MuSK can be detected in early embryonic chick muscle and is up-regulated after nerve injury. More importantly, we also demonstrate that, in the chicken, MuSK mRNA is expressed during development in brain and liver, suggesting possible novel functions for MuSK. Furthermore, the regulatory profile of MuSK expression in chick muscle closely parallels that observed for acetylcholine receptor, in terms of both mRNA expression and protein localization. Finally, studies with paralyzed chicken muscle as well as with cultured chick myotubes demonstrate the dependence of MuSK on both electrical activity and trophic factors.-
dc.languageeng-
dc.relation.ispartofMolecular and Cellular Neuroscience-
dc.titleCloning and characterization of muscle-specific kinase in chicken-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/mcne.2000.0892-
dc.identifier.pmid11083926-
dc.identifier.scopuseid_2-s2.0-0034530366-
dc.identifier.volume16-
dc.identifier.issue5-
dc.identifier.spage661-
dc.identifier.epage673-
dc.identifier.isiWOS:000165611200011-

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