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Article: Identification and characterization of splice variants of ephrin-A3 and ephrin-A5

TitleIdentification and characterization of splice variants of ephrin-A3 and ephrin-A5
Authors
Issue Date1999
Citation
FEBS Letters, 1999, v. 458 n. 2, p. 265-269 How to Cite?
AbstractEphrins and Eph receptors have been implicated to play important roles in axon guidance. A variable spacer region exists that differs significantly among distinct ephrins. An ephrin-A5 isoform has previously been isolated which lacks 27 amino acids within the spacer region. The expression and biological activities of this isoform, as well as the existence of isoforms for other ephrins that show variation within the spacer region, remain unknown. We report here a novel alternatively spliced isoform of ephrin-A3 which lacks the corresponding variable region. When compared to the longer isoforms, the shorter isoforms of both ephrin-A3 and ephrin-A5 remained less prominent in the brain during development, though their expression increased at postnatal stages. In addition, they could inhibit neurite outgrowth of dorsal root ganglia (DRG) neurons, suggesting that the corresponding variable regions were not essential for their axon guidance activities. Copyright (C) 1999 Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/196640
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, K-O-
dc.contributor.authorIp, FCF-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:30Z-
dc.date.available2014-04-24T02:10:30Z-
dc.date.issued1999-
dc.identifier.citationFEBS Letters, 1999, v. 458 n. 2, p. 265-269-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10722/196640-
dc.description.abstractEphrins and Eph receptors have been implicated to play important roles in axon guidance. A variable spacer region exists that differs significantly among distinct ephrins. An ephrin-A5 isoform has previously been isolated which lacks 27 amino acids within the spacer region. The expression and biological activities of this isoform, as well as the existence of isoforms for other ephrins that show variation within the spacer region, remain unknown. We report here a novel alternatively spliced isoform of ephrin-A3 which lacks the corresponding variable region. When compared to the longer isoforms, the shorter isoforms of both ephrin-A3 and ephrin-A5 remained less prominent in the brain during development, though their expression increased at postnatal stages. In addition, they could inhibit neurite outgrowth of dorsal root ganglia (DRG) neurons, suggesting that the corresponding variable regions were not essential for their axon guidance activities. Copyright (C) 1999 Federation of European Biochemical Societies.-
dc.languageeng-
dc.relation.ispartofFEBS Letters-
dc.titleIdentification and characterization of splice variants of ephrin-A3 and ephrin-A5-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-5793(99)01159-X-
dc.identifier.pmid10481078-
dc.identifier.scopuseid_2-s2.0-0032840061-
dc.identifier.volume458-
dc.identifier.issue2-
dc.identifier.spage265-
dc.identifier.epage269-
dc.identifier.isiWOS:000082769200038-

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