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Article: Muscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures

TitleMuscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures
Authors
Issue Date1997
Citation
NeuroReport, 1997, v. 8 n. 18, p. 3895-3900 How to Cite?
AbstractNeurotrophins, a group of protein ligands that are structurally related to the prototype nerve growth factor (NGF), are prominently expressed in the skeletal muscle during the critical period of synapse formation. In the present study, we utilized a co-culture system of NG108-15 cells expressing the Trk receptors and C2C12 myotubes expressing the individual neurotrophins to examine whether these factors can act in a target-derived manner to influence the postsynaptic specializations. Our findings demonstrated that muscle-derived neurotrophin-3 (NT-3) has the unique ability to enhance the aggregation of acetylcholine receptors (AChRs) on the myotubes following co- culture with NG108-15 cells expressing TrkC. Taken together, our findings suggest that NT-3 can act as a retrograde factor to modulate the postsynaptic specializations.
Persistent Identifierhttp://hdl.handle.net/10722/196621
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFu, AKY-
dc.contributor.authorIp, FCF-
dc.contributor.authorLai, KO-
dc.contributor.authorTsim, KWK-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:28Z-
dc.date.available2014-04-24T02:10:28Z-
dc.date.issued1997-
dc.identifier.citationNeuroReport, 1997, v. 8 n. 18, p. 3895-3900-
dc.identifier.issn0959-4965-
dc.identifier.urihttp://hdl.handle.net/10722/196621-
dc.description.abstractNeurotrophins, a group of protein ligands that are structurally related to the prototype nerve growth factor (NGF), are prominently expressed in the skeletal muscle during the critical period of synapse formation. In the present study, we utilized a co-culture system of NG108-15 cells expressing the Trk receptors and C2C12 myotubes expressing the individual neurotrophins to examine whether these factors can act in a target-derived manner to influence the postsynaptic specializations. Our findings demonstrated that muscle-derived neurotrophin-3 (NT-3) has the unique ability to enhance the aggregation of acetylcholine receptors (AChRs) on the myotubes following co- culture with NG108-15 cells expressing TrkC. Taken together, our findings suggest that NT-3 can act as a retrograde factor to modulate the postsynaptic specializations.-
dc.languageeng-
dc.relation.ispartofNeuroReport-
dc.titleMuscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-199712220-00011-
dc.identifier.pmid9462462-
dc.identifier.scopuseid_2-s2.0-0031583912-
dc.identifier.volume8-
dc.identifier.issue18-
dc.identifier.spage3895-
dc.identifier.epage3900-
dc.identifier.isiWOS:000071221500012-

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