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Article: Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors

TitleRole of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors
Authors
Issue Date2013
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 2013, v. 19 n. Suppl. 4, p. 29-35 How to Cite?
Abstract1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.
Persistent Identifierhttp://hdl.handle.net/10722/196376
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLee, MYen_US
dc.contributor.authorCheung, CYen_US
dc.contributor.authorPeiris, JSMen_US
dc.date.accessioned2014-04-01T08:52:03Z-
dc.date.available2014-04-01T08:52:03Z-
dc.date.issued2013en_US
dc.identifier.citationHong Kong Medical Journal, 2013, v. 19 n. Suppl. 4, p. 29-35en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/196376-
dc.description.abstract1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.en_US
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRole of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitorsen_US
dc.typeArticleen_US
dc.identifier.emailLee, MY: suki@hku.hken_US
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityLee, MY=rp01536en_US
dc.identifier.authorityCheung, CY=rp00404en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturepublished_or_final_version-
dc.identifier.pmid23775184-
dc.identifier.scopuseid_2-s2.0-84893435117-
dc.identifier.hkuros228438en_US
dc.identifier.volume19en_US
dc.identifier.issueSuppl. 4en_US
dc.identifier.spage29en_US
dc.identifier.epage35en_US
dc.publisher.placeHong Kong-

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