File Download
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-84893435117
- PMID: 23775184
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors
Title | Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors |
---|---|
Authors | |
Issue Date | 2013 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk |
Citation | Hong Kong Medical Journal, 2013, v. 19 n. Suppl. 4, p. 29-35 How to Cite? |
Abstract | 1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade. |
Persistent Identifier | http://hdl.handle.net/10722/196376 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, MY | en_US |
dc.contributor.author | Cheung, CY | en_US |
dc.contributor.author | Peiris, JSM | en_US |
dc.date.accessioned | 2014-04-01T08:52:03Z | - |
dc.date.available | 2014-04-01T08:52:03Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Hong Kong Medical Journal, 2013, v. 19 n. Suppl. 4, p. 29-35 | en_US |
dc.identifier.issn | 1024-2708 | - |
dc.identifier.uri | http://hdl.handle.net/10722/196376 | - |
dc.description.abstract | 1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade. | en_US |
dc.language | eng | en_US |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk | - |
dc.relation.ispartof | Hong Kong Medical Journal | en_US |
dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, MY: suki@hku.hk | en_US |
dc.identifier.email | Cheung, CY: chungey@hkucc.hku.hk | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.authority | Lee, MY=rp01536 | en_US |
dc.identifier.authority | Cheung, CY=rp00404 | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.pmid | 23775184 | - |
dc.identifier.scopus | eid_2-s2.0-84893435117 | - |
dc.identifier.hkuros | 228438 | en_US |
dc.identifier.hkuros | 277056 | - |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | Suppl. 4 | en_US |
dc.identifier.spage | 29 | en_US |
dc.identifier.epage | 35 | en_US |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1024-2708 | - |