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Article: Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration

TitleRetinal ganglion cells are resistant to photoreceptor loss in retinal degeneration
Authors
Issue Date2013
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2013, v. 8 n. 6, p. e68084 How to Cite?
AbstractThe rapid and massive degeneration of photoreceptors in retinal degeneration might have a dramatic negative effect on retinal circuits downstream of photoreceptors. However, the impact of photoreceptor loss on the morphology and function of retinal ganglion cells (RGCs) is not fully understood, precluding the rational design of therapeutic interventions that can reverse the progressive loss of retinal function. The present study investigated the morphological changes in several identified RGCs in the retinal degeneration rd1 mouse model of retinitis pigmentosa (RP), using a combination of viral transfection, microinjection of neurobiotin and confocal microscopy. Individual RGCs were visualized with a high degree of detail using an adeno-associated virus (AAV) vector carrying the gene for enhanced green fluorescent protein (EGFP), allowed for large-scale surveys of the morphology of RGCs over a wide age range. Interestingly, we found that the RGCs of nine different types we encountered were especially resistant to photoreceptor degeneration, and retained their fine dendritic geometry well beyond the complete death of photoreceptors. In addition, the RGC-specific markers revealed a remarkable degree of stability in both morphology and numbers of two identified types of RGCs for up to 18 months of age. Collectively, our data suggest that ganglion cells, the only output cells of the retina, are well preserved morphologically, indicating the ganglion cell population might be an attractive target for treating vision loss.
Persistent Identifierhttp://hdl.handle.net/10722/195654
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, Ben_US
dc.contributor.authorPeng, Ben_US
dc.date.accessioned2014-03-07T04:20:56Z-
dc.date.available2014-03-07T04:20:56Z-
dc.date.issued2013en_US
dc.identifier.citationPLoS One, 2013, v. 8 n. 6, p. e68084en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/195654-
dc.description.abstractThe rapid and massive degeneration of photoreceptors in retinal degeneration might have a dramatic negative effect on retinal circuits downstream of photoreceptors. However, the impact of photoreceptor loss on the morphology and function of retinal ganglion cells (RGCs) is not fully understood, precluding the rational design of therapeutic interventions that can reverse the progressive loss of retinal function. The present study investigated the morphological changes in several identified RGCs in the retinal degeneration rd1 mouse model of retinitis pigmentosa (RP), using a combination of viral transfection, microinjection of neurobiotin and confocal microscopy. Individual RGCs were visualized with a high degree of detail using an adeno-associated virus (AAV) vector carrying the gene for enhanced green fluorescent protein (EGFP), allowed for large-scale surveys of the morphology of RGCs over a wide age range. Interestingly, we found that the RGCs of nine different types we encountered were especially resistant to photoreceptor degeneration, and retained their fine dendritic geometry well beyond the complete death of photoreceptors. In addition, the RGC-specific markers revealed a remarkable degree of stability in both morphology and numbers of two identified types of RGCs for up to 18 months of age. Collectively, our data suggest that ganglion cells, the only output cells of the retina, are well preserved morphologically, indicating the ganglion cell population might be an attractive target for treating vision loss.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRetinal ganglion cells are resistant to photoreceptor loss in retinal degenerationen_US
dc.typeArticleen_US
dc.identifier.emailLin, B: blin@hku.hken_US
dc.identifier.authorityLin, B=rp01356en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0068084-
dc.identifier.pmid23840814-
dc.identifier.pmcidPMC3695938-
dc.identifier.hkuros228170en_US
dc.identifier.volume8en_US
dc.identifier.issue6-
dc.identifier.spagee68084en_US
dc.identifier.epagee68084en_US
dc.identifier.isiWOS:000321148400161-
dc.publisher.placeUnited States-

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