File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1371/journal.pone.0068084
- Scopus: eid_2-s2.0-84879522623
- PMID: 23840814
- WOS: WOS:000321148400161
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration
Title | Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration |
---|---|
Authors | |
Issue Date | 2013 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | PLoS One, 2013, v. 8 n. 6, p. e68084 How to Cite? |
Abstract | The rapid and massive degeneration of photoreceptors in retinal degeneration might have a dramatic negative effect on retinal circuits downstream of photoreceptors. However, the impact of photoreceptor loss on the morphology and function of retinal ganglion cells (RGCs) is not fully understood, precluding the rational design of therapeutic interventions that can reverse the progressive loss of retinal function. The present study investigated the morphological changes in several identified RGCs in the retinal degeneration rd1 mouse model of retinitis pigmentosa (RP), using a combination of viral transfection, microinjection of neurobiotin and confocal microscopy. Individual RGCs were visualized with a high degree of detail using an adeno-associated virus (AAV) vector carrying the gene for enhanced green fluorescent protein (EGFP), allowed for large-scale surveys of the morphology of RGCs over a wide age range. Interestingly, we found that the RGCs of nine different types we encountered were especially resistant to photoreceptor degeneration, and retained their fine dendritic geometry well beyond the complete death of photoreceptors. In addition, the RGC-specific markers revealed a remarkable degree of stability in both morphology and numbers of two identified types of RGCs for up to 18 months of age. Collectively, our data suggest that ganglion cells, the only output cells of the retina, are well preserved morphologically, indicating the ganglion cell population might be an attractive target for treating vision loss. |
Persistent Identifier | http://hdl.handle.net/10722/195654 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, B | en_US |
dc.contributor.author | Peng, B | en_US |
dc.date.accessioned | 2014-03-07T04:20:56Z | - |
dc.date.available | 2014-03-07T04:20:56Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | PLoS One, 2013, v. 8 n. 6, p. e68084 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10722/195654 | - |
dc.description.abstract | The rapid and massive degeneration of photoreceptors in retinal degeneration might have a dramatic negative effect on retinal circuits downstream of photoreceptors. However, the impact of photoreceptor loss on the morphology and function of retinal ganglion cells (RGCs) is not fully understood, precluding the rational design of therapeutic interventions that can reverse the progressive loss of retinal function. The present study investigated the morphological changes in several identified RGCs in the retinal degeneration rd1 mouse model of retinitis pigmentosa (RP), using a combination of viral transfection, microinjection of neurobiotin and confocal microscopy. Individual RGCs were visualized with a high degree of detail using an adeno-associated virus (AAV) vector carrying the gene for enhanced green fluorescent protein (EGFP), allowed for large-scale surveys of the morphology of RGCs over a wide age range. Interestingly, we found that the RGCs of nine different types we encountered were especially resistant to photoreceptor degeneration, and retained their fine dendritic geometry well beyond the complete death of photoreceptors. In addition, the RGC-specific markers revealed a remarkable degree of stability in both morphology and numbers of two identified types of RGCs for up to 18 months of age. Collectively, our data suggest that ganglion cells, the only output cells of the retina, are well preserved morphologically, indicating the ganglion cell population might be an attractive target for treating vision loss. | en_US |
dc.language | eng | en_US |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, B: blin@hku.hk | en_US |
dc.identifier.authority | Lin, B=rp01356 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pone.0068084 | - |
dc.identifier.pmid | 23840814 | - |
dc.identifier.pmcid | PMC3695938 | - |
dc.identifier.scopus | eid_2-s2.0-84879522623 | - |
dc.identifier.hkuros | 228170 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 6 | - |
dc.identifier.spage | e68084 | en_US |
dc.identifier.epage | e68084 | en_US |
dc.identifier.isi | WOS:000321148400161 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1932-6203 | - |