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Article: Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa

TitleDevelopment and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 8, p. e44036 How to Cite?
AbstractRetinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood. To explore these issues, we backcrossed a transgenic mouse expressing enhanced green fluorescent protein (EGFP) in one subset of cone bipolar cells (type 7) into rd1 mice, a classic mouse model of retinal degeneration, to examine the development and survival of cone bipolar cells in a background of retinal degeneration. Our data revealed that both the development and degeneration of cone bipolar cells are independent of the normal activity of cone photoreceptors. We found that type 7 cone bipolar cells achieved a uniform tiling of the retinal surface and developed normal dendritic and axonal arbors without the influence of cone photoreceptor innervation. On the other hand, degeneration of type 7 cone bipolar cells, contrary to our belief of central-to-peripheral progression, was spatially uniform across the retina independent of the spatiotemporal pattern of cone degeneration. The results have important implications for the design of more effective therapies to restore vision in retinal degeneration.
Persistent Identifierhttp://hdl.handle.net/10722/195653
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Men_US
dc.contributor.authorWang, Ken_US
dc.contributor.authorLin, Ben_US
dc.date.accessioned2014-03-07T04:20:55Z-
dc.date.available2014-03-07T04:20:55Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 8, p. e44036en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/195653-
dc.description.abstractRetinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood. To explore these issues, we backcrossed a transgenic mouse expressing enhanced green fluorescent protein (EGFP) in one subset of cone bipolar cells (type 7) into rd1 mice, a classic mouse model of retinal degeneration, to examine the development and survival of cone bipolar cells in a background of retinal degeneration. Our data revealed that both the development and degeneration of cone bipolar cells are independent of the normal activity of cone photoreceptors. We found that type 7 cone bipolar cells achieved a uniform tiling of the retinal surface and developed normal dendritic and axonal arbors without the influence of cone photoreceptor innervation. On the other hand, degeneration of type 7 cone bipolar cells, contrary to our belief of central-to-peripheral progression, was spatially uniform across the retina independent of the spatiotemporal pattern of cone degeneration. The results have important implications for the design of more effective therapies to restore vision in retinal degeneration.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDevelopment and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosaen_US
dc.typeArticleen_US
dc.identifier.emailChen, M: miaoc@hku.hken_US
dc.identifier.emailLin, B: blin@hku.hken_US
dc.identifier.authorityLin, B=rp01356en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0044036-
dc.identifier.pmid22952865-
dc.identifier.pmcidPMC3432094-
dc.identifier.hkuros228169en_US
dc.identifier.volume7en_US
dc.identifier.issue8-
dc.identifier.spagee44036en_US
dc.identifier.epagee44036en_US
dc.identifier.isiWOS:000308221300045-
dc.publisher.placeUnited States-

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