File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1371/journal.pone.0044036
- Scopus: eid_2-s2.0-84865624024
- PMID: 22952865
- WOS: WOS:000308221300045
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa
Title | Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa |
---|---|
Authors | |
Issue Date | 2012 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | PLoS One, 2012, v. 7 n. 8, p. e44036 How to Cite? |
Abstract | Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood. To explore these issues, we backcrossed a transgenic mouse expressing enhanced green fluorescent protein (EGFP) in one subset of cone bipolar cells (type 7) into rd1 mice, a classic mouse model of retinal degeneration, to examine the development and survival of cone bipolar cells in a background of retinal degeneration. Our data revealed that both the development and degeneration of cone bipolar cells are independent of the normal activity of cone photoreceptors. We found that type 7 cone bipolar cells achieved a uniform tiling of the retinal surface and developed normal dendritic and axonal arbors without the influence of cone photoreceptor innervation. On the other hand, degeneration of type 7 cone bipolar cells, contrary to our belief of central-to-peripheral progression, was spatially uniform across the retina independent of the spatiotemporal pattern of cone degeneration. The results have important implications for the design of more effective therapies to restore vision in retinal degeneration. |
Persistent Identifier | http://hdl.handle.net/10722/195653 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, M | en_US |
dc.contributor.author | Wang, K | en_US |
dc.contributor.author | Lin, B | en_US |
dc.date.accessioned | 2014-03-07T04:20:55Z | - |
dc.date.available | 2014-03-07T04:20:55Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | PLoS One, 2012, v. 7 n. 8, p. e44036 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10722/195653 | - |
dc.description.abstract | Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood. To explore these issues, we backcrossed a transgenic mouse expressing enhanced green fluorescent protein (EGFP) in one subset of cone bipolar cells (type 7) into rd1 mice, a classic mouse model of retinal degeneration, to examine the development and survival of cone bipolar cells in a background of retinal degeneration. Our data revealed that both the development and degeneration of cone bipolar cells are independent of the normal activity of cone photoreceptors. We found that type 7 cone bipolar cells achieved a uniform tiling of the retinal surface and developed normal dendritic and axonal arbors without the influence of cone photoreceptor innervation. On the other hand, degeneration of type 7 cone bipolar cells, contrary to our belief of central-to-peripheral progression, was spatially uniform across the retina independent of the spatiotemporal pattern of cone degeneration. The results have important implications for the design of more effective therapies to restore vision in retinal degeneration. | en_US |
dc.language | eng | en_US |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chen, M: miaoc@hku.hk | en_US |
dc.identifier.email | Lin, B: blin@hku.hk | en_US |
dc.identifier.authority | Lin, B=rp01356 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pone.0044036 | - |
dc.identifier.pmid | 22952865 | - |
dc.identifier.pmcid | PMC3432094 | - |
dc.identifier.scopus | eid_2-s2.0-84865624024 | - |
dc.identifier.hkuros | 228169 | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 8 | - |
dc.identifier.spage | e44036 | en_US |
dc.identifier.epage | e44036 | en_US |
dc.identifier.isi | WOS:000308221300045 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1932-6203 | - |