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Article: Antibody-mediated pure neutrophil aplasia, recurrent myasthenia gravis and previous thymoma: Case report and literature review

TitleAntibody-mediated pure neutrophil aplasia, recurrent myasthenia gravis and previous thymoma: Case report and literature review
Authors
Issue Date1990
Citation
Quarterly Journal of Medicine, 1990, v. 74 n. 273, p. 57-61 How to Cite?
AbstractWe describe a case of neutrophil aplasia in a woman with recurrent myasthenia gravis and a past history of thymoma. Bone marrow showed virtually absent granulopoiesis but normal erythropoiesis and megakaryopoiesis. Bone marrow cultures showed no growth of granulocyte/mononuclear cell progenitors (CFU-GM). She was treated with immunosuppression including azathioprine, and her neutrophil count returned to normal. Serum before treatment, and also an IgG fraction thereof, inhibited CFU-GM growth both in autologous 'remission' marrow and in allogeneic marrow. She remains in complete remission 36 months after starting azathioprine. This association is extremely rare, and was formerly associated with a grim prognosis.
Persistent Identifierhttp://hdl.handle.net/10722/195374
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMathieson, PW-
dc.contributor.authorO'Neill, JH-
dc.contributor.authorDurrant, STS-
dc.contributor.authorHenderson, SJ-
dc.contributor.authorGreen, PJ-
dc.contributor.authorNewsom-Davis, J-
dc.date.accessioned2014-02-28T06:12:03Z-
dc.date.available2014-02-28T06:12:03Z-
dc.date.issued1990-
dc.identifier.citationQuarterly Journal of Medicine, 1990, v. 74 n. 273, p. 57-61-
dc.identifier.issn0033-5622-
dc.identifier.urihttp://hdl.handle.net/10722/195374-
dc.description.abstractWe describe a case of neutrophil aplasia in a woman with recurrent myasthenia gravis and a past history of thymoma. Bone marrow showed virtually absent granulopoiesis but normal erythropoiesis and megakaryopoiesis. Bone marrow cultures showed no growth of granulocyte/mononuclear cell progenitors (CFU-GM). She was treated with immunosuppression including azathioprine, and her neutrophil count returned to normal. Serum before treatment, and also an IgG fraction thereof, inhibited CFU-GM growth both in autologous 'remission' marrow and in allogeneic marrow. She remains in complete remission 36 months after starting azathioprine. This association is extremely rare, and was formerly associated with a grim prognosis.-
dc.languageeng-
dc.relation.ispartofQuarterly Journal of Medicine-
dc.titleAntibody-mediated pure neutrophil aplasia, recurrent myasthenia gravis and previous thymoma: Case report and literature review-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid2326435-
dc.identifier.scopuseid_2-s2.0-0025014839-
dc.identifier.volume74-
dc.identifier.issue273-
dc.identifier.spage57-
dc.identifier.epage61-
dc.identifier.isiWOS:A1990CL11100007-

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