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- Scopus: eid_2-s2.0-0025014839
- PMID: 2326435
- WOS: WOS:A1990CL11100007
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Article: Antibody-mediated pure neutrophil aplasia, recurrent myasthenia gravis and previous thymoma: Case report and literature review
Title | Antibody-mediated pure neutrophil aplasia, recurrent myasthenia gravis and previous thymoma: Case report and literature review |
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Authors | |
Issue Date | 1990 |
Citation | Quarterly Journal of Medicine, 1990, v. 74 n. 273, p. 57-61 How to Cite? |
Abstract | We describe a case of neutrophil aplasia in a woman with recurrent myasthenia gravis and a past history of thymoma. Bone marrow showed virtually absent granulopoiesis but normal erythropoiesis and megakaryopoiesis. Bone marrow cultures showed no growth of granulocyte/mononuclear cell progenitors (CFU-GM). She was treated with immunosuppression including azathioprine, and her neutrophil count returned to normal. Serum before treatment, and also an IgG fraction thereof, inhibited CFU-GM growth both in autologous 'remission' marrow and in allogeneic marrow. She remains in complete remission 36 months after starting azathioprine. This association is extremely rare, and was formerly associated with a grim prognosis. |
Persistent Identifier | http://hdl.handle.net/10722/195374 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mathieson, PW | - |
dc.contributor.author | O'Neill, JH | - |
dc.contributor.author | Durrant, STS | - |
dc.contributor.author | Henderson, SJ | - |
dc.contributor.author | Green, PJ | - |
dc.contributor.author | Newsom-Davis, J | - |
dc.date.accessioned | 2014-02-28T06:12:03Z | - |
dc.date.available | 2014-02-28T06:12:03Z | - |
dc.date.issued | 1990 | - |
dc.identifier.citation | Quarterly Journal of Medicine, 1990, v. 74 n. 273, p. 57-61 | - |
dc.identifier.issn | 0033-5622 | - |
dc.identifier.uri | http://hdl.handle.net/10722/195374 | - |
dc.description.abstract | We describe a case of neutrophil aplasia in a woman with recurrent myasthenia gravis and a past history of thymoma. Bone marrow showed virtually absent granulopoiesis but normal erythropoiesis and megakaryopoiesis. Bone marrow cultures showed no growth of granulocyte/mononuclear cell progenitors (CFU-GM). She was treated with immunosuppression including azathioprine, and her neutrophil count returned to normal. Serum before treatment, and also an IgG fraction thereof, inhibited CFU-GM growth both in autologous 'remission' marrow and in allogeneic marrow. She remains in complete remission 36 months after starting azathioprine. This association is extremely rare, and was formerly associated with a grim prognosis. | - |
dc.language | eng | - |
dc.relation.ispartof | Quarterly Journal of Medicine | - |
dc.title | Antibody-mediated pure neutrophil aplasia, recurrent myasthenia gravis and previous thymoma: Case report and literature review | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 2326435 | - |
dc.identifier.scopus | eid_2-s2.0-0025014839 | - |
dc.identifier.volume | 74 | - |
dc.identifier.issue | 273 | - |
dc.identifier.spage | 57 | - |
dc.identifier.epage | 61 | - |
dc.identifier.isi | WOS:A1990CL11100007 | - |
dc.identifier.issnl | 0033-5622 | - |