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Article: Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy

TitleInterleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy
Authors
Issue Date1999
Citation
Clinical Science, 1999, v. 96 n. 6, p. 665-668 How to Cite?
AbstractMinimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy. Polymorphic regions in the genes encoding IL-4 itself and the IL-4 receptor have been demonstrated that may predipose to increased activity. We have analysed these polymorphisms in 149 patients with MCN and 73 controls to test the hypothesis that these loci are involved in genetic predisposition to MCN. In our populations there were no polymorphisms in the IL-4 promoter. We did confirm allelic variation in a dinucleotide repeat in the second intron of the IL-4 gene, but there was no significant difference between allele distributions in MCN and controls. Similarly, allele frequencies for the IL-4 receptor α chain polymorphism were similar in patients and controls. Genetic loci which are believed to influence IL-4 responsiveness and to predispose to atopy do not appear to be associated with susceptibility to MCN.
Persistent Identifierhttp://hdl.handle.net/10722/195357
ISSN
2015 Impact Factor: 4.996
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorParry, RG-
dc.contributor.authorGillespie, KM-
dc.contributor.authorParnham, A-
dc.contributor.authorClark, AGB-
dc.contributor.authorMathieson, PW-
dc.date.accessioned2014-02-28T06:12:02Z-
dc.date.available2014-02-28T06:12:02Z-
dc.date.issued1999-
dc.identifier.citationClinical Science, 1999, v. 96 n. 6, p. 665-668-
dc.identifier.issn0143-5221-
dc.identifier.urihttp://hdl.handle.net/10722/195357-
dc.description.abstractMinimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy. Polymorphic regions in the genes encoding IL-4 itself and the IL-4 receptor have been demonstrated that may predipose to increased activity. We have analysed these polymorphisms in 149 patients with MCN and 73 controls to test the hypothesis that these loci are involved in genetic predisposition to MCN. In our populations there were no polymorphisms in the IL-4 promoter. We did confirm allelic variation in a dinucleotide repeat in the second intron of the IL-4 gene, but there was no significant difference between allele distributions in MCN and controls. Similarly, allele frequencies for the IL-4 receptor α chain polymorphism were similar in patients and controls. Genetic loci which are believed to influence IL-4 responsiveness and to predispose to atopy do not appear to be associated with susceptibility to MCN.-
dc.languageeng-
dc.relation.ispartofClinical Science-
dc.titleInterleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1042/CS19980391-
dc.identifier.pmid10334974-
dc.identifier.scopuseid_2-s2.0-0032988804-
dc.identifier.volume96-
dc.identifier.issue6-
dc.identifier.spage665-
dc.identifier.epage668-
dc.identifier.isiWOS:000080884400017-

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